5ZKQ | | CRYSTAL STRUCTURE OF THE HUMAN PLATELET-ACTIVATING FACTOR RECEPTOR IN COMPLEX WITH ABT-491 | | Descriptor: | Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... | | Authors: | Cao, C., Zhao, Q., Zhang, X.C., Wu, B. | | Deposit date: | 2018-03-25 | | Release date: | 2018-06-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
|
|
6BR1 | | TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4A | | Descriptor: | Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... | | Authors: | Kumar, G., Wang, Y., Li, W., White, S.W. | | Deposit date: | 2017-11-29 | | Release date: | 2018-06-27 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.304 Å) | | Cite: | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
|
|
6BRF | | TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4B | | Descriptor: | Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... | | Authors: | Kumar, G., Wang, Y., Li, W., White, S.W. | | Deposit date: | 2017-11-30 | | Release date: | 2018-06-27 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
|
|
6BRY | | TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 6A | | Descriptor: | Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... | | Authors: | Kumar, G., Wang, Y., Li, W., White, S.W. | | Deposit date: | 2017-12-01 | | Release date: | 2018-06-27 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
|
|
6BS2 | | TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 8B | | Descriptor: | Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... | | Authors: | Kumar, G., Wang, Y., Li, W., White, S.W. | | Deposit date: | 2017-12-01 | | Release date: | 2018-06-27 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
|
|
4ZN2 | |
3UPR | | HLA-B*57:01 COMPLEXED TO PEP-V AND ABACAVIR | | Descriptor: | HLA class I histocompatibility antigen, B-57 alpha chain, pep-V, ... | | Authors: | Pompeu, Y.A., Ostrov, D.A. | | Deposit date: | 2011-11-18 | | Release date: | 2012-06-13 | | Last modified: | 2012-11-14 | | Method: | X-RAY DIFFRACTION (1.999 Å) | | Cite: | Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
5NAR | |
5NAW | | COMPLEMENT FACTOR D IN COMPLEX WITH THE INHIBITOR (1R,3S,5R)-2-AZA-BICYCLO[3.1.0]HEXANE-2,3-DICARBOXYLIC ACID 2-[(1-CARBAMOYL-1H-INDOL-3-YL)-AMIDE] 3-[(3-TRIFLUOROMETHOXY-PHENYL)-AMIDE] | | Descriptor: | Complement factor D, (1~{R},3~{S},5~{R})-~{N}2-(1-aminocarbonylindol-3-yl)-~{N}3-[3-(trifluoromethyloxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide | | Authors: | Mac Sweeney, A., Ostermann, N. | | Deposit date: | 2017-02-28 | | Release date: | 2017-06-28 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60, 2017
|
|
5NB6 | | COMPLEMENT FACTOR D IN COMPLEX WITH THE INHIBITOR (2S,4S)-4-AMINO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-[(1-CARBAMOYL-1H-INDOL-3-YL)-AMIDE] 2-[(3-TRIFLUOROMETHOXY-PHENYL)-AMIDE] | | Descriptor: | Complement factor D, (2~{S},4~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-4-azanyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide | | Authors: | Mac Sweeney, A., Ostermann, N. | | Deposit date: | 2017-03-01 | | Release date: | 2017-06-28 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60, 2017
|
|
5NB7 | | COMPLEMENT FACTOR D | | Descriptor: | Complement factor D, DIMETHYL SULFOXIDE, 1-[2-[(1~{R},3~{S},5~{R})-3-[(6-bromanylpyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]indazole-3-carboxamide | | Authors: | Mac Sweeney, A., Ostermann, N. | | Deposit date: | 2017-03-01 | | Release date: | 2017-06-28 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60, 2017
|
|
5NBA | | COMPLEMENT FACTOR D IN COMPLEX WITH THE INHIBITOR (2S,4R)-4-FLUORO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-[(1-CARBAMOYL-1H-INDOL-3-YL)-AMIDE] 2-[(3-TRIFLUOROMETHOXY-PHENYL)-AMIDE] | | Descriptor: | Complement factor D, (2~{S},4~{R})-~{N}1-(1-aminocarbonylindol-3-yl)-4-fluoranyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide | | Authors: | Mac Sweeney, A., Ostermann, N. | | Deposit date: | 2017-03-01 | | Release date: | 2017-06-28 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60, 2017
|
|
5XS4 | | STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE | | Descriptor: | Genome polyprotein | | Authors: | Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T. | | Deposit date: | 2017-06-12 | | Release date: | 2017-09-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
|
|
5XS5 | | STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS PROCAPSID PARTICLE | | Descriptor: | Genome polyprotein | | Authors: | Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Cheng, T., Li, S.W. | | Deposit date: | 2017-06-12 | | Release date: | 2017-09-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
|
|
5XS7 | | STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE IN COMPLEX WITH THE NEUTRALIZING ANTIBODY FRAGMENT 1D5 | | Descriptor: | Light chain of Fab 1D5, Heavy chain of Fab 1D5, Genome polyprotein | | Authors: | Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T. | | Deposit date: | 2017-06-12 | | Release date: | 2017-09-27 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
|
|
5ZTM | | CRYSTAL STRUCTURE OF MLE DSRBDS IN COMPLEX WITH ROX2 (R2H1) | | Descriptor: | Dosage compensation regulator, non-coding mRNA sequence roX2 | | Authors: | Lv, M.Q., Tang, Y.J. | | Deposit date: | 2018-05-04 | | Release date: | 2019-03-06 | | Last modified: | 2019-04-24 | | Method: | X-RAY DIFFRACTION (2.899 Å) | | Cite: | Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
Nucleic Acids Res., 47, 2019
|
|
6AJ0 | | THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION | | Descriptor: | Viral protein 1, Virion protein 2, Capsid protein VP3, ... | | Authors: | Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. | | Deposit date: | 2018-08-25 | | Release date: | 2018-11-07 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
|
|
6AJ2 | | THE STRUCTURE OF ICAM-5 TRIGGERED ENTEROVIRUS D68 VIRUS A-PARTICLE | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | Authors: | Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. | | Deposit date: | 2018-08-26 | | Release date: | 2018-11-07 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
|
|
6AJ3 | | THE STRUCTURE OF ENTEROVIRUS D68 PROCAPSID | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | | Authors: | Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. | | Deposit date: | 2018-08-26 | | Release date: | 2018-11-07 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
|
|
6AJ7 | | THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 | | Descriptor: | VL of Fab 15C5, VH of Fab 15C5, Capsid protein VP1, ... | | Authors: | Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. | | Deposit date: | 2018-08-27 | | Release date: | 2018-11-07 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
|
|
6AJ9 | | THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1 | | Descriptor: | VL of Fab 11G1, VH of Fab 11G1, VL of Fab 15C5, ... | | Authors: | Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W. | | Deposit date: | 2018-08-27 | | Release date: | 2018-11-07 | | Last modified: | 2018-12-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
|
|
6J20 | | CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR | | Descriptor: | Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one | | Authors: | Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q. | | Deposit date: | 2018-12-30 | | Release date: | 2019-03-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
|
|
6J21 | | CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR | | Descriptor: | Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | | Authors: | Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q. | | Deposit date: | 2018-12-30 | | Release date: | 2019-03-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
|
|
4NQF | |
4XE9 | |
