Author results

4DXA
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CO-CRYSTAL STRUCTURE OF RAP1 IN COMPLEX WITH KRIT1
分子名称:Ras-related protein Rap-1b, Krev interaction trapped protein 1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Li, X., Zhang, R., Boggon, T.J.
登録日2012-02-27
公開日2012-05-16
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1).
J.Biol.Chem., 287, 2012
4EIR
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STRUCTURAL BASIS FOR SUBSTRATE TARGETING AND CATALYSIS BY FUNGAL POLYSACCHARIDE MONOOXYGENASES (PMO-2)
分子名称:polysaccharide monooxygenase-2, COPPER (II) ION, OXYGEN MOLECULE, ...
著者Li, X., Beeson, W.T., Phillips, C.M., Marletta, M.A., Cate, J.H.
登録日2012-04-05
公開日2012-05-23
最終更新日2012-06-27
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases.
Structure, 20, 2012
4EIS
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STRUCTURAL BASIS FOR SUBSTRATE TARGETING AND CATALYSIS BY FUNGAL POLYSACCHARIDE MONOOXYGENASES (PMO-3)
分子名称:polysaccharide monooxygenase-3, COPPER (II) ION, PEROXIDE ION, ...
著者Li, X., Beeson, W.T., Phillips, C.M., Marletta, M.A., Cate, J.H.
登録日2012-04-05
公開日2012-05-23
最終更新日2012-06-27
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases.
Structure, 20, 2012
4FWI
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CRYSTAL STRUCTURE OF THE NUCLEOTIDE-BINDING DOMAIN OF A DIPEPTIDE ABC TRANSPORTER
分子名称:ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component, IRON/SULFUR CLUSTER, ...
著者Li, X., Ge, J., Yang, M., Wang, N.
登録日2012-07-01
公開日2013-01-30
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (2.892 Å)
主引用文献Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain
Acta Crystallogr.,Sect.D, 69, 2013
4JPB
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THE STRUCTURE OF A TERNARY COMPLEX BETWEEN CHEA DOMAINS P4 AND P5 WITH CHEW AND WITH AN UNZIPPED FRAGMENT OF TM14, A CHEMORECEPTOR ANALOG FROM THERMOTOGA MARITIMA.
分子名称:Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein
著者Li, X., Bayas, C., Bilwes, A.M., Crane, B.R.
登録日2013-03-19
公開日2013-08-28
実験手法X-RAY DIFFRACTION (3.186 Å)
主引用文献The 3.2 angstrom resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
Biochemistry, 52, 2013
4KMN
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STRUCTURE OF CIAP1-BIR3 AND INHIBITOR
分子名称:Baculoviral IAP repeat-containing protein 2, ZINC ION, (2S)-N-{(2R)-1-[(2R,4S)-2-{[6,6'-difluoro-3'-({(2R,4S)-4-hydroxy-1-[(2S)-2-{[(2S)-2-(methylamino)propanoyl]amino}butanoyl]pyrrolidin-2-yl}methyl)-1H,1'H-2,2'-biindol-3-yl]methyl}-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl}-2-(methylamino)propanamide, ...
著者Li, X., Wang, J., Condon, S.M., Shi, Y.
登録日2013-05-08
公開日2014-05-14
実験手法X-RAY DIFFRACTION (1.523 Å)
主引用文献Structure of cIAP1-BIR3 and inhibitor
To be Published
4KMP
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STRUCTURE OF XIAP-BIR3 AND INHIBITOR
分子名称:E3 ubiquitin-protein ligase XIAP, ZINC ION, (2S,2'S)-N,N'-[(6,6'-difluoro-1H,1'H-2,2'-biindole-3,3'-diyl)bis{methanediyl[(2R,4S)-4-hydroxypyrrolidine-2,1-diyl][(2S)-1-oxobutane-1,2-diyl]}]bis[2-(methylamino)propanamide]
著者Li, X., Wang, J., Condon, S.M., Shi, Y.
登録日2013-05-08
公開日2014-05-14
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of XIAP-BIR3 and inhibitor
To be Published
4QRD
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STRUCTURE OF METHIONYL-TRNA SYNTHETASE IN COMPLEX WITH N-(1H-BENZIMIDAZOL-2-YLMETHYL)-N'-(2,4-DICHLOROPHENYL)-6-(MORPHOLIN-4-YL)-1,3,5-TRIAZINE-2,4-DIAMINE
分子名称:Methionyl-tRNA synthetase, MAGNESIUM ION, N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine
著者Li, X., Hilgers, M.T., Stidham, M., Brown-Driver, V., Shaw, K.J., Finn, J.
登録日2014-06-30
公開日2015-07-29
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase
to be published
4QUV
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STRUCTURE OF AN INTEGRAL MEMBRANE DELTA(14)-STEROL REDUCTASE
分子名称:Delta(14)-sterol reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Li, X., Blobel, G.
登録日2014-07-12
公開日2014-10-08
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (2.743 Å)
主引用文献Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
Nature, 517, 2015
4WCW
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RIBOSOMAL SILENCING FACTOR DURING STARVATION OR STATIONARY PHASE (RSFS) FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:Ribosomal silencing factor RsfS, MAGNESIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Li, X., Sun, Q., Jiang, C., Yang, K., Hung, L., Zhang, J., Sacchettini, J., TB Structural Genomics Consortium (TBSGC)
登録日2014-09-05
公開日2014-09-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.
Structure, 23, 2015
5IM7
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CRYSTAL STRUCTURE OF HLA-B5801, A PROTECTIVE HLA ALLELE FOR HIV-1 INFECTION
分子名称:HLA-B*58:01 Heavy Chain, Beta-2-microglobulin, GLN-ALA-SER-GLN-GLU-VAL-LYS-ASN-TRP
著者Li, X., Wang, J.-H.
登録日2016-03-05
公開日2016-10-05
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.
Protein Cell, 7, 2016
5INC
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CRYSTAL STRUCTURE OF HLA-B5801, A PROTECTIVE HLA ALLELE FOR HIV-1 INFECTION
分子名称:HLA class I histocompatibility antigen, B-58 alpha chain, Beta-2-microglobulin, ...
著者Li, X., Wang, J.-H.
登録日2016-03-07
公開日2016-10-05
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (2.881 Å)
主引用文献Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.
Protein Cell, 7, 2016
5IND
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CRYSTAL STRUCTURE OF HLA-B5801, A PROTECTIVE HLA ALLELE FOR HIV-1 INFECTION
分子名称:HLA class I histocompatibility antigen, B-58 alpha chain, Beta-2-microglobulin, ...
著者Li, X., Wang, J.-H.
登録日2016-03-07
公開日2016-10-05
最終更新日2016-10-19
実験手法X-RAY DIFFRACTION (2.132 Å)
主引用文献Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.
Protein Cell, 7, 2016
5U73
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CRYSTAL STRUCTURE OF HUMAN NIEMANN-PICK C1 PROTEIN
分子名称:Niemann-Pick C1 protein, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
著者Li, X., Wang, J., Blobel, G.
登録日2016-12-11
公開日2017-09-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.348 Å)
主引用文献3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U74
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STRUCTURE OF HUMAN NIEMANN-PICK C1 PROTEIN
分子名称:Niemann-Pick C1 protein, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
著者Li, X.
登録日2016-12-11
公開日2017-10-11
実験手法X-RAY DIFFRACTION (3.335 Å)
主引用文献3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UZ5
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S. CEREVISIAE U1 SNRNP
分子名称:U1 small nuclear ribonucleoprotein 70 kDa homolog, U1 small nuclear ribonucleoprotein C, U1 small nuclear ribonucleoprotein A,TAP tag, ...
著者Li, X., Liu, S., Jiang, J., Zhang, L., Espinosa, S., Hill, R.C., Hansen, K.C., Zhou, Z.H., Zhao, R.
登録日2017-02-24
公開日2017-11-15
最終更新日2018-10-03
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Nat Commun, 8, 2017
5V5L
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CRYSTAL STRUCTURE OF HLA-B*5801 COMPLEX WITH HIV-1 GAG DERIVED PEPTIDE TW10
分子名称:HLA class I histocompatibility antigen, B-58 alpha chain, Beta-2-microglobulin, ...
著者Li, X., Wang, J.-H.
登録日2017-03-14
公開日2017-06-14
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.
Cell. Mol. Immunol., 14, 2017
5V5M
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CRYSTAL STRUCTURE OF HLA-B*5701 COMPLEX WITH HIV-1 GAG DERIVED PEPTIDE TW10
分子名称:HLA class I histocompatibility antigen, B-57 alpha chain, Beta-2-microglobulin, ...
著者Li, X., Wang, J.-H.
登録日2017-03-14
公開日2017-06-14
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (2.878 Å)
主引用文献Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.
Cell. Mol. Immunol., 14, 2017
5VB3
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X-RAY STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN + SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION
著者Li, X.
登録日2017-03-28
公開日2017-06-07
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB5
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN INVERSE AGONIST AND SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
著者Li, X.
登録日2017-03-28
公開日2017-06-07
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.226 Å)
主引用文献Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB6
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN INVERSE AGONIST AND SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
著者Li, X.
登録日2017-03-28
公開日2017-06-07
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.041 Å)
主引用文献Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VB7
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH AN AGONIST AND SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
著者Li, X.
登録日2017-03-28
公開日2017-06-07
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.335 Å)
主引用文献Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors.
J. Biol. Chem., 292, 2017
5VQK
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH A INVERSE AGONIST AND SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, 1-(4-fluorophenyl)-7-methoxy-N-{[4-(methylsulfamoyl)phenyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide
著者Li, X.
登録日2017-05-09
公開日2018-05-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide
To Be Published
5VQL
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X-RAY CO-STRUCTURE OF NUCLEAR RECEPTOR ROR-GAMMAT LIGAND BINDING DOMAIN WITH A INVERSE AGONIST AND SRC2 PEPTIDE
分子名称:Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, ...
著者Li, X.
登録日2017-05-09
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide
To Be Published
5WNE
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X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
分子名称:Rho-associated protein kinase 1, 3,4-dimethoxy-N-({3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}methyl)benzamide, GLYCEROL
著者Li, X.
登録日2017-07-31
公開日2018-08-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Novel mechanism of Rho kinase selectivity: beyond the ATP pocket
To Be Published