Author results

3MZF
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STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 FROM E. COLI: IMIPENEM ACYL-ENZYME COMPLEX
Descriptor:D-alanyl-D-alanine carboxypeptidase dacA, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, GLYCEROL
Authors:Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
3UN7
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CRYSTAL STRUCTURE OF PBPA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Penicillin-binding protein A
Authors:Fedarovich, A., Davies, C.
Deposit date:2011-11-15
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
4U3T
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CRYSTAL STRUCTURE OF THE TRANSPEPTIDASE DOMAIN OF NEISSERIA GONORRHOEAE PENICILLIN-BINDING PROTEIN 2 DERIVED FROM THE PENICILLIN-RESISTANT STRAIN 6140
Descriptor:Penicillin-binding protein 2
Authors:Fedarovich, A., Davies, C.
Deposit date:2014-07-22
Release date:2014-12-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Effect of the Asp345a Insertion in Penicillin-Binding Protein 2 from Penicillin-Resistant Strains of Neisseria gonorrhoeae.
Biochemistry, 53, 2014
5HM6
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N-TERMINAL DOMAIN OF BFMR FROM ACINETOBACTER BAUMANNII
Descriptor:BfmR
Authors:Roth, B.R., Davies, C.
Deposit date:2016-01-15
Release date:2017-01-18
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
J. Mol. Biol., 2018
5KSH
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CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM NEISSERIA GONORRHOEAE CONTAINING AN A501T MUTATION ASSOCIATED WITH CEPHALOSPORIN RESISTANCE
Descriptor:Penicillin-binding protein 2, GLYCEROL, SULFATE ION
Authors:Fedarovich, A., Davies, C.
Deposit date:2016-07-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.
Biochemistry, 56, 2017
1RL6
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RIBOSOMAL PROTEIN L6
Descriptor:PROTEIN (RIBOSOMAL PROTEIN L6)
Authors:Golden, B.L., Davies, C., Ramakrishnan, V., White, S.W.
Deposit date:1999-01-14
Release date:1999-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein.
EMBO J., 12, 1993
5AAU
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OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST
Descriptor:ESTROGEN RECEPTOR, 3-(1-(4-Chlorophenyl)-3,4-dihydro-1H-pyrido(3,4-b)indol-2(9H)-yl)propanoic acid
Authors:Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
Deposit date:2015-07-28
Release date:2015-10-14
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
5AAV
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OPTIMIZATION OF A NOVEL BINDING MOTIF TO TO (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H- PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID (AZD9496), A POTENT AND ORALLY BIOAVAILABLE SELECTIVE ESTROGEN RECEPTOR DOWNREGULATOR AND ANTAGONIST
Descriptor:ESTROGEN RECEPTOR, (2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID
Authors:Norman, R.A., Bradbury, R.H., de Almeida, C., Andrews, D.M., Ballard, P., Buttar, D., Callis, R.J., Currie, G.S., Curwen, J.O., Davies, C.D., de Savi, C., Donald, C.S., Feron, L.J.L., Glossop, S.C., Hayter, B.R., Karoutchi, G., Lamont, S.G., MacFaul, P., Moss, T., Pearson, S.E., Rabow, A.A., Tonge, M., Walker, G.E., Weir, H.M., Wilson, Z.
Deposit date:2015-07-29
Release date:2015-10-14
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J.Med.Chem., 58, 2015
1EG0
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FITTING OF COMPONENTS WITH KNOWN STRUCTURE INTO AN 11.5 A CRYO-EM MAP OF THE E.COLI 70S RIBOSOME
Descriptor:FRAGMENT OF 16S RRNA HELIX 23, FRAGMENT OF 23S RRNA, HELIX 95 OF 23S RRNA, ...
Authors:Gabashvili, I.S., Agrawal, R.K., Spahn, C.M.T., Grassucci, R.A., Svergun, D.I., Frank, J., Penczek, P.
Deposit date:2000-02-11
Release date:2000-03-06
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Solution structure of the E. coli 70S ribosome at 11.5 A resolution.
Cell(Cambridge,Mass.), 100, 2000
3Q2G
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ADAMTS1 IN COMPLEX WITH A NOVEL N-HYDROXYFORMAMIDE INHIBITORS
Descriptor:A disintegrin and metalloproteinase with thrombospondin motifs 1, N-[(2S,4S)-1-({4-[(2,4-dichlorobenzyl)oxy]piperidin-1-yl}sulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl]-N-hydroxyformamide, ZINC ION, ...
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2010-12-20
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
Bioorg.Med.Chem.Lett., 21, 2011
3Q2H
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ADAMTS1 IN COMPLEX WITH N-HYDROXYFORMAMIDE INHIBITORS OF ADAM-TS4
Descriptor:A disintegrin and metalloproteinase with thrombospondin motifs 1, ZINC ION, CADMIUM ION, ...
Authors:Gerhardt, S., Hargreaves, D.
Deposit date:2010-12-20
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
Bioorg.Med.Chem.Lett., 21, 2011
487D
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SEVEN RIBOSOMAL PROTEINS FITTED TO A CRYO-ELECTRON MICROSCOPIC MAP OF THE LARGE 50S SUBUNIT AT 7.5 ANGSTROMS RESOLUTION
Descriptor:PROTEIN (50S L1 RIBOSOMAL PROTEIN), PROTEIN (50S L2 RIBOSOMAL PROTEIN), PROTEIN (50S L6 RIBOSOMAL PROTEIN), ...
Authors:Brimacombe, R., Mueller, F.
Deposit date:2000-02-23
Release date:2000-04-10
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution.
J.Mol.Biol., 298, 2000
1QD7
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PARTIAL MODEL FOR 30S RIBOSOMAL SUBUNIT
Descriptor:CENTRAL FRAGMENT OF 16 S RNA, END FRAGMENT OF 16 S RNA, S4 RIBOSOMAL PROTEIN, ...
Authors:Clemons Jr., W.M., May, J.L.C., Wimberly, B.T., McCutcheon, J.P., Capel, M.S., Ramakrishnan, V.
Deposit date:1999-07-09
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution.
Nature, 400, 1999
1XF2
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STRUCTURE OF FAB DNA-1 COMPLEXED WITH DT3
Descriptor:5'-D(*TP*TP*T)-3', antibody light chain Fab, antibody heavy chain Fab, ...
Authors:Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J.
Deposit date:2004-09-13
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition
J.Mol.Biol., 347, 2005
1XF3
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STRUCTURE OF LIGAND-FREE FAB DNA-1 IN SPACE GROUP P65
Descriptor:Fab Light chain, Fab heavy chain
Authors:Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J.
Deposit date:2004-09-13
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition
J.Mol.Biol., 347, 2005
1XF4
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STRUCTURE OF LIGAND-FREE FAB DNA-1 IN SPACE GROUP P321 SOLVED FROM CRYSTALS WITH PERFECT HEMIHEDRAL TWINNING
Descriptor:Fab light chain, Fab heavy chain, SULFATE ION
Authors:Schuermann, J.P., Prewitt, S.P., Deutscher, S.L., Tanner, J.J.
Deposit date:2004-09-13
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition
J.Mol.Biol., 347, 2005
2NAZ
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THE SOLUTION NMR STRUCTURE OF THE C-TERMINAL EFFECTOR DOMAIN OF BFMR FROM ACINETOBACTER BAUMANNII
Descriptor:Transcriptional regulatory protein RstA
Authors:Olson, A.L., Thompson, R.J., Cavanagh, J., Feldmann, E.A., Bobay, B.G.
Deposit date:2016-01-15
Release date:2017-01-18
Last modified:2018-02-28
Method:SOLUTION NMR
Cite:The structure of the biofilm-controlling response regulator BfmR from Acinetobacter baumannii reveals details of its DNA-binding mechanism.
J. Mol. Biol., 2018
2VGJ
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CRYSTAL STRUCTURE OF ACTINOMADURA R39 DD-PEPTIDASE COMPLEXED WITH A PEPTIDOGLYCAN-MIMETIC CEPHALOSPORIN
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, CEPHALOSPORIN, SULFATE ION, ...
Authors:Sauvage, E., kerff, F., Herman, R., Charlier, P.
Deposit date:2007-11-14
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Complexes of Bacterial Dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle.
J.Mol.Biol., 381, 2008
2VGK
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CRYSTAL STRUCTURE OF ACTINOMADURA R39 DD-PEPTIDASE COMPLEXED WITH A PEPTIDOGLYCAN-MIMETIC CEPHALOSPORIN
Descriptor:D-ALANYL-D-ALANINE CARBOXYPEPTIDASE, (2R)-2-AMINO-7-{[(1R)-1-CARBOXYETHYL]AMINO}-7-OXOHEPTANOIC ACID, SULFATE ION, ...
Authors:Sauvage, E., kerff, F., Herman, R., Charlier, P.
Deposit date:2007-11-14
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structures of Complexes of Bacterial Dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle.
J.Mol.Biol., 381, 2008
6BR7
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BERYLLIUM FLUORINATED RECEIVER DOMAIN OF BFMR FROM ACINETOBACTER BAUMANNII
Descriptor:Two-component system response regulator protein, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION
Authors:Milton, M.E., Cavanagh, J.
Deposit date:2017-11-30
Release date:2018-02-21
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
J. Mol. Biol., 430, 2018
6CWY
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CRYSTAL STRUCTURE OF SUMO E1 IN COMPLEX WITH AN ALLOSTERIC INHIBITOR
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ...
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
6CWZ
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CRYSTAL STRUCTURE OF APO SUMO E1
Descriptor:SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ZINC ION
Authors:Lv, Z., Yuan, L., Atkison, J.H., Williams, K.M., Olsen, S.K.
Deposit date:2018-04-01
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.
Nat Commun, 9, 2018
1CQU
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SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF RIBOSOMAL PROTEIN L9
Descriptor:50S RIBOSOMAL PROTEIN L9
Authors:Hua, Y., Kuhlman, B., Hoffman, D., Raleigh, D.P.
Deposit date:1999-08-11
Release date:2002-04-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Effects of varying the local propensity to form secondary structure on the stability and folding kinetics of a rapid folding mixed alpha/beta protein: characterization of a truncation mutant of the N-terminal domain of the ribosomal protein L9.
J.Mol.Biol., 289, 1999
1FKA
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STRUCTURE OF FUNCTIONALLY ACTIVATED SMALL RIBOSOMAL SUBUNIT AT 3.3 A RESOLUTION
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Schluenzen, F., Tocilj, A., Zarivach, R., Harms, J., Gluehmann, M., Janell, D., Bashan, A., Bartels, H., Agmon, I., Franceschi, F., Yonath, A.
Deposit date:2000-08-09
Release date:2000-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution.
Cell(Cambridge,Mass.), 102, 2000
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