Author results

5YNM
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAM AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYLMETHIONINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNN
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10COMPLEX BOUND TO SINEFUNGIN AND M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, SINEFUNGIN, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNP
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SINEFUNGIN AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, SINEFUNGIN, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
5YNQ
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAH AND M7GPPPG
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-25
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.958 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
3P4Z
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TIME-DEPENDENT AND PROTEIN-DIRECTED IN SITU GROWTH OF GOLD NANOPARTICLES IN A SINGLE CRYSTAL OF LYSOZYME
Descriptor:Lysozyme C, GOLD ION, CHLORIDE ION, ...
Authors:Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y.-G., Yang, L., Robinson, H., Tan, L.H., Xing, H., Hou, C., Robertson, I.M., Zuo, J.-M., Lu, Y.
Deposit date:2010-10-07
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
3P64
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TIME-DEPENDENT AND PROTEIN-DIRECTED IN SITU GROWTH OF GOLD NANOPARTICLES IN A SINGLE CRYSTAL OF LYSOZYME
Descriptor:Lysozyme C, GOLD 3+ ION, GOLD ION, ...
Authors:Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y.-G., Yang, L., Robinson, H., Tan, L.H., Xing, H., Hou, C., Robertson, I.M., Zuo, J.-M., Lu, Y.
Deposit date:2010-10-11
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
3P65
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TIME-DEPENDENT AND PROTEIN-DIRECTED IN SITU GROWTH OF GOLD NANOPARTICLES IN A SINGLE CRYSTAL OF LYSOZYME
Descriptor:Lysozyme C, GOLD 3+ ION, GOLD ION, ...
Authors:Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y.-G., Yang, L., Robinson, H., Tan, L.H., Xing, H., Hou, C., Robertson, I.M., Zuo, J.-M., Lu, Y.
Deposit date:2010-10-11
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
3P66
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TIME-DEPENDENT AND PROTEIN-DIRECTED IN SITU GROWTH OF GOLD NANOPARTICLES IN A SINGLE CRYSTAL OF LYSOZYME
Descriptor:Lysozyme C, GOLD 3+ ION
Authors:Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y.-G., Yang, L., Robinson, H., Tan, L.H., Xing, H., Hou, C., Robertson, I.M., Zuo, J.-M., Lu, Y.
Deposit date:2010-10-11
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
3P68
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TIME-DEPENDENT AND PROTEIN-DIRECTED IN SITU GROWTH OF GOLD NANOPARTICLES IN A SINGLE CRYSTAL OF LYSOZYME
Descriptor:Lysozyme C, GOLD 3+ ION
Authors:Wei, H., Wang, Z., Zhang, J., House, S., Gao, Y.-G., Yang, L., Robinson, H., Tan, L.H., Xing, H., Hou, C., Robertson, I.M., Zuo, J.-M., Lu, Y.
Deposit date:2010-10-11
Release date:2011-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme.
Nat Nanotechnol, 6, 2011
4JZR
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STRUCTURE OF PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) WITH INHIBITORS
Descriptor:Egl nine homolog 1, NICKEL (II) ION, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, ...
Authors:Ma, Y., Yang, L.
Deposit date:2013-04-03
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors
Bioorg.Med.Chem., 21, 2013
4XYX
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NANB PLUS OPTACTAMIDE
Descriptor:Sialidase B, Optactamide, PHOSPHATE ION
Authors:Rogers, G.W., Brear, P., Yang, L., Taylor, G.L., Westwood, N.J.
Deposit date:2015-02-03
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To Be Published
5YNO
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CRYSTAL STRUCTURE OF MERS-COV NSP16/NSP10 COMPLEX BOUND TO SAH AND M7GPPPA
Descriptor:nsp16 protein, nsp10 protein, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
Deposit date:2017-10-24
Release date:2018-12-05
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex
To Be Published
6NEF
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OUTER MEMBRANE CYTOCHROME S FILAMENT FROM GEOBACTER SULFURREDUCENS
Descriptor:Cytochrome C, PROTOPORPHYRIN IX CONTAINING FE, MAGNESIUM ION
Authors:Filman, D.J., Marino, S.F., Ward, J.E., Yang, L., Mester, Z., Bullitt, E., Lovley, D.R., Strauss, M.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.
Commun Biol, 2, 2019
5BTU
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THE STRUCTURE OF DIELS-ALDERASE PYRI4 IN THE BIOSYNTHETIC PATHWAY OF PYRROINDOMYCINS
Descriptor:PyrI4, GLYCEROL, DI(HYDROXYETHYL)ETHER
Authors:Pan, L., Guo, Y., Liu, J.
Deposit date:2015-06-03
Release date:2016-02-24
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4
Cell Chem Biol, 23, 2016
5BU3
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CRYSTAL STRUCTURE OF DIELS-ALDERASE PYRI4 IN COMPLEX WITH ITS PRODUCT
Descriptor:PyrI4, GLYCEROL, (4S,4aS,6aS,8R,9R,10aR,13R,14aS,18aR,18bR)-9-ethyl-4,8,19-trihydroxy-10a,12,13,18a-tetramethyl-2,3,4,4a,5,6,6a,7,8,9,10,10a,13,14,18a,18b-hexadecahydro-1H-14a,17-(metheno)benzo[b]naphtho[2,1-h]azacyclododecine-16,18(15H,17H)-dione
Authors:Pan, L., Guo, Y., Liu, J.
Deposit date:2015-06-03
Release date:2016-02-24
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Enzyme-Dependent [4 + 2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4
Cell Chem Biol, 23, 2016
5TKJ
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STRUCTURE OF VACCINE-ELICITED DIVERSE HIV-1 NEUTRALIZING ANTIBODY VFP1.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP1.01 chimeric mouse antibody heavy chain, vFP1.01 chimeric mouse antibody light chain, HIV-1 fusion peptide residue 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2016-10-06
Release date:2018-04-04
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
5TKK
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STRUCTURE OF MOUSE VACCINATION-ELICITED HIV NEUTRALIZING ANTIBODY VFP5.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:HIV-1 fusion peptide residue 512-519, mouse antibody vFP5.01 heavy chain, mouse antibody vFP5.01 light chain
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2016-10-06
Release date:2018-04-04
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
5YP5
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CRYSTAL STRUCTURE OF RORGAMMA COMPLEXED WITH SRC2 AND COMPOUND 5D
Descriptor:Nuclear receptor ROR-gamma, SRC2-2 peptide, 2-[4-(ethylsulfonyl)phenyl]-N-{5-[2-(2-methylpropyl)benzoyl]-4-phenyl-1,3-thiazol-2-yl}acetamide
Authors:Gao, M., Cai, W., Chunwa, C.
Deposit date:2017-11-01
Release date:2018-04-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
5YP6
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RORGAMMA (263-509) COMPLEXED WITH SRC2 AND COMPOUND 6
Descriptor:Nuclear receptor ROR-gamma, SRC2, N-[3'-cyano-4'-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide
Authors:Gao, M., Cai, W.
Deposit date:2017-11-01
Release date:2018-02-07
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists
ACS Med Chem Lett, 9, 2018
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDI
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CRYO-EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:Glycoprotein gp41, Glycoprotein 120, PGT122 Light Chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDM
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP7.04 heavy chain, vFP7.04 light chain, HIV fusion peptide (512-519)
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDO
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP16.02 Fab heavy chain, vFP16.02 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDP
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VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP20.01 Fab heavy chain, vFP20.01 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
4XT9
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RORGAMMA (263-509) COMPLEXED WITH GSK2435341A AND SRC2
Descriptor:Nuclear receptor ROR-gamma, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, ...
Authors:Wang, Y., Ma, Y.
Deposit date:2015-01-23
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
Bioorg.Med.Chem., 23, 2015