Author results

1S5O
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STRUCTURAL AND MUTATIONAL CHARACTERIZATION OF L-CARNITINE BINDING TO HUMAN CARNITINE ACETYLTRANSFERASE
分子名称:carnitine acetyltransferase isoform 2, CARNITINE
著者Govindasamy, L., Kukar, T., Lian, W., Pedersen, B., Gu, Y., Agbandje-Mckenna, M., Jin, S., Mckenna, R., Wu, D.
登録日2004-01-21
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase.
J.Struct.Biol., 146, 2004
1Z14
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STRUCTURAL DETERMINANTS OF TISSUE TROPISM AND IN VIVO PATHOGENICITY FOR THE PARVOVIRUS MINUTE VIRUS OF MICE
分子名称:VP2
著者Kontou, M., Govindasamy, L., Nam, H.J., Bryant, N., Llamas-Saiz, A.L., Foces-Foces, C., Hernando, E., Rubio, M.P., McKenna, R., Almendral, J.M., Agbandje-McKenna, M.
登録日2005-03-03
公開日2005-09-06
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
J.Virol., 79, 2005
1Z93
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HUMAN CARBONIC ANHYDRASE III:STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
分子名称:Carbonic anhydrase III, ZINC ION
著者Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
登録日2005-03-31
公開日2005-08-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
1Z97
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HUMAN CARBONIC ANHYDRASE III: STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
分子名称:Carbonic anhydrase III, ZINC ION
著者Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
登録日2005-03-31
公開日2005-08-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
2ANL
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X-RAY CRYSTAL STRUCTURE OF THE ASPARTIC PROTEASE PLASMEPSIN 4 FROM THE MALARIAL PARASITE PLASMODIUM MALARIAE BOUND TO AN ALLOPHENYLNORSTATINE BASED INHIBITOR
分子名称:plasmepsin IV, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
著者Clemente, J.C., Govindasamy, L., Madabushi, A., Fisher, S.Z., Moose, R.E., Yowell, C.A., Hidaka, K., Kimura, T., Hayashi, Y., Kiso, Y., Agbandje-McKenna, M., Dame, J.B., Dunn, B.M., McKenna, R.
登録日2005-08-11
公開日2006-04-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
2AQU
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STRUCTURE OF HIV-1 PROTEASE BOUND TO ATAZANAVIR
分子名称:HIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5,6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER
著者Clemente, J.C., Coman, R.M., Thiaville, M.M., Janka, L.K., Jeung, J.A., Nukoolkarn, S., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Leelamanit, W., Goodenow, M.M., Dunn, B.M.
登録日2005-08-18
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry, 45, 2006
2B60
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO RITONAVIR
分子名称:Gag-Pol polyprotein, GLYCEROL, RITONAVIR
著者Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
登録日2005-09-29
公開日2006-11-14
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
2B7Z
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO INDINAVIR
分子名称:HIV-1 protease, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
著者Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
登録日2005-10-05
公開日2006-11-14
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
2EU2
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
分子名称:Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE
著者Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
登録日2005-10-28
公開日2006-07-11
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2EU3
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
分子名称:Carbonic anhydrase 2, ZINC ION, 1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE
著者Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
登録日2005-10-28
公開日2006-07-11
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2G8G
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STRUCTURALLY MAPPING THE DIVERSE PHENOTYPE OF ADENO-ASSOCIATED VIRUS SEROTYPE 4
分子名称:Capsid, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE
著者Govindasamy, L., Padron, E., McKenna, R., Muzyczka, N., Chiorini, J.A., Agbandje-McKenna, M.
登録日2006-03-02
公開日2007-01-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
J.Virol., 80, 2006
2OSF
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INHIBITION OF CARBONIC ANHYDRASE II BY THIOXOLONE: A MECHANISTIC AND STRUCTURAL STUDY
分子名称:Carbonic anhydrase 2, ZINC ION, 4-MERCAPTOBENZENE-1,3-DIOL, ...
著者Albert, A.B., Caroli, G., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Tripp, B.C.
登録日2007-02-05
公開日2008-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry, 47, 2008
2OSM
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INHIBITION OF CARBONIC ANHYDRASE II BY THIOXOLONE: A MECHANISTIC AND STRUCTURAL STUDY
分子名称:Carbonic anhydrase 2, ZINC ION, 2-MERCAPTOPHENOL
著者Albert, A.B., Caroli, G., Govindasamy, L., Agbandje-Mckenna, M., McKenna, R., Tripp, B.C.
登録日2007-02-06
公開日2008-02-12
最終更新日2012-12-26
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study.
Biochemistry, 47, 2008
3D8W
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USE OF A CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase II, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-05-26
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3D9Z
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-05-28
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DAZ
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-05-30
公開日2009-03-03
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DBU
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-02
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DC3
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DC9
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCC
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-03
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCS
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DCW
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3DD0
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USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES
分子名称:Carbonic anhydrase 2, ZINC ION, 6-ethoxy-1,3-benzothiazole-2-sulfonamide
著者Genis, C., Sippel, K.H., Case, N., Govindasamy, L., Agbandje-Mckenna, M., Mckenna, R.
登録日2008-06-04
公開日2009-03-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48, 2009
3HS4
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE
分子名称:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
著者Robbins, A.H., Genis, C., Domsic, J., Sippel, K.H., Agbandje-McKenna, M., McKenna, R.
登録日2009-06-10
公開日2009-12-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.
Acta Crystallogr.,Sect.F, 65, 2009
3NG9
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STRUCTURE TO FUNCTION CORRELATIONS FOR ADENO-ASSOCIATED VIRUS SEROTYPE 1
分子名称:Capsid protein, ADENINE, 6-AMINOPYRIMIDIN-2(1H)-ONE
著者Govindasamy, L., Miller, E.B., Gurda, B., McKenna, R., Zolotukhin, S., Muzyczka, N., Agbandje-McKenna, M.
登録日2010-06-11
公開日2011-12-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure to Function Correlations for Adeno-Associated Virus serotype 1
To be Published