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5OIP
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INHA (T2A MUTANT) COMPLEXED WITH 1-(PYRIDIN-3-YLMETHYL)-3-(1-(PYRIMIDIN-2-YL)PIPERIDIN-4-YL)UREA
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-(pyridin-3-ylmethyl)-3-(1-pyrimidin-2-ylpiperidin-4-yl)urea, ...
Authors:Convery, M.A.
Deposit date:2017-07-19
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem, 13, 2018
5OIQ
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INHA (T2A MUTANT) COMPLEXED WITH 2,6-DIMETHYL-3-PHENYLPYRIDIN-4(1H)-ONE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], 2,6-dimethyl-3-phenyl-1~{H}-pyridin-4-one, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Convery, M.A.
Deposit date:2017-07-19
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem, 13, 2018
5OIR
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INHA (T2A MUTANT) COMPLEXED WITH 2,6-DIMETHYL-3-(1-(PYRIMIDIN-2-YL)PIPERIDIN-4-YL)PYRIDIN-4(1H)-ONE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 2,6-dimethyl-3-(1-pyrimidin-2-ylpiperidin-4-yl)-1~{H}-pyridin-4-one, ...
Authors:Convery, M.A.
Deposit date:2017-07-19
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem, 13, 2018
5OIS
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INHA (T2A MUTANT) COMPLEXED WITH 4-((5-AMINO-3-METHYL-1H-PYRAZOL-1-YL)METHYL)-N-(2-CHLORO-4-FLUOROBENZYL)BENZAMIDE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], 4-[(5-azanyl-3-methyl-pyrazol-1-yl)methyl]-~{N}-[(2-chloranyl-4-fluoranyl-phenyl)methyl]benzamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Convery, M.A.
Deposit date:2017-07-19
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem, 13, 2018
5OIT
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INHA (T2A MUTANT) COMPLEXED WITH 5-((5-AMINO-3-METHYL-1H-PYRAZOL-1-YL)METHYL)-N-(1-(2-CHLORO-6-FLUOROBENZYL)-1H-PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], 5-[(5-azanyl-3-methyl-pyrazol-1-yl)methyl]-~{N}-[1-[(2-chloranyl-6-fluoranyl-phenyl)methyl]pyrazol-3-yl]-1,3,4-thiadiazol-2-amine, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Convery, M.A.
Deposit date:2017-07-19
Release date:2018-02-14
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.
ChemMedChem, 13, 2018
5ELN
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM CRYPTOSPORIDIUM PARVUM COMPLEXED WITH L-LYSINE
Descriptor:Lysine--tRNA ligase, LYSINE, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 2019
5ELO
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM CRYPTOSPORIDIUM PARVUM COMPLEXED WITH L-LYSINE AND CLADOSPORIN
Descriptor:Lysine--tRNA ligase, LYSINE, cladosporin, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 2019
6AGT
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CRYSTAL STRUCTURE OF PFKRS COMPLEXED WITH CHROMONE INHIBITOR
Descriptor:Lysine--tRNA ligase, N-(cyclohexylmethyl)-4-oxo-4H-1-benzopyran-2-carboxamide, COBALT (II) ION, ...
Authors:Yogavel, M., Sharma, A., Sharma, A., Baragana, B., Walpole, C.
Deposit date:2018-08-14
Release date:2019-03-13
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6HCU
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM PLASMODIUM FALCIPARUM BOUND TO A DIFLUORO CYCLOHEXYL CHROMONE LIGAND
Descriptor:Lysine--tRNA ligase, ~{N}-[[4,4-bis(fluoranyl)-1-oxidanyl-cyclohexyl]methyl]-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, LYSINE, ...
Authors:Tamjar, J., Robinson, D.A., Baragana, B., Norcross, N., Forte, B., Walpole, C., Gilbert, I.H.
Deposit date:2018-08-16
Release date:2019-04-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6HCV
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM PLASMODIUM FALCIPARUM COMPLEXED WITH A CHROMONE LIGAND
Descriptor:Lysine--tRNA ligase, 6-fluoranyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide
Authors:Robinson, D.A., Baragana, B., Norcross, N., Forte, B., Walpole, C., Gilbert, I.H.
Deposit date:2018-08-16
Release date:2019-04-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6HCW
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CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM CRYPTOSPORIDIUM PARVUM COMPLEXED WITH L-LYSINE AND A DIFLUORO CYCLOHEXYL CHROMONE LIGAND
Descriptor:Lysine--tRNA ligase, LYSINE, ~{N}-[[4,4-bis(fluoranyl)-1-oxidanyl-cyclohexyl]methyl]-6-fluoranyl-4-oxidanylidene-chromene-2-carboxamide, ...
Authors:Robinson, D.A., Baragana, B., Norcross, N., Forte, B., Walpole, C., Gilbert, I.H.
Deposit date:2018-08-16
Release date:2019-04-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6QM7
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LEISHMANIA TARENTOLAE PROTEASOME 20S SUBUNIT COMPLEXED WITH GSK3494245
Descriptor:Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ...
Authors:Rowland, P., Goswami, P.
Deposit date:2019-02-01
Release date:2019-04-17
Last modified:2019-05-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116, 2019
6QM8
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LEISHMANIA TARENTOLAE PROTEASOME 20S SUBUNIT APO STRUCTURE
Descriptor:Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ...
Authors:Rowland, P., Goswami, P.
Deposit date:2019-02-01
Release date:2019-04-17
Last modified:2019-05-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116, 2019
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