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5XTO
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CRYSTAL STRUCTURE OF BACULOVIRAL SULFHYDRYL OXIDASE P33 (H114A MUTANT)
Descriptor:FAD-linked sulfhydryl oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kuang, W., Hu, Z., Gong, P.
Deposit date:2017-06-20
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function
J. Virol., 91, 2017
5XTP
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CRYSTAL STRUCTURE OF BACULOVIRAL SULFHYDRYL OXIDASE P33 (H227A MUTANT)
Descriptor:FAD-linked sulfhydryl oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kuang, W., Hu, Z., Gong, P.
Deposit date:2017-06-20
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function
J. Virol., 91, 2017
5XTQ
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CRYSTAL STRUCTURE OF BACULOVIRAL SULFHYDRYL OXIDASE P33 (H227D MUTANT)
Descriptor:FAD-linked sulfhydryl oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Kuang, W., Hu, Z., Gong, P.
Deposit date:2017-06-20
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function
J. Virol., 91, 2017
5XTR
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CRYSTAL STRUCTURE OF BACULOVIRAL SULFHYDRYL OXIDASE P33 (R127A, E183A MUTANT)
Descriptor:FAD-linked sulfhydryl oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Kuang, W., Hu, Z., Gong, P.
Deposit date:2017-06-20
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function
J. Virol., 91, 2017
5YS2
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STRUCTURE OF THE DOMAIN IV(D_IV) OF PSEUDORABIES VIRUS GLYCOPROTEIN B( PRV GB)
Descriptor:Envelope glycoprotein B,Envelope glycoprotein B
Authors:Hu, X.L., Yang, F.L.
Deposit date:2017-11-12
Release date:2017-12-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.
PLoS Pathog., 13, 2017
5YSL
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CRYSTAL STRUCTURE OF ANTIBODY 1H1 FAB
Descriptor:1H1 heavy chain, 1H1 light chain
Authors:Hu, X.L., Yang, F.L.
Deposit date:2017-11-14
Release date:2017-12-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design.
PLoS Pathog., 13, 2017
6B41
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MENIN BOUND TO M-525
Descriptor:Menin, methyl {(1S,2R)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate, praseodymium triacetate
Authors:Stuckey, J.A.
Deposit date:2017-09-25
Release date:2018-01-24
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Angew. Chem. Int. Ed. Engl., 57, 2018
6B5Q
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DCN1 BOUND TO 38
Descriptor:DCN1-like protein 1, Peptidomimetic Inhibitors DI-591, TRIETHYLENE GLYCOL
Authors:Stuckey, J.
Deposit date:2017-09-29
Release date:2018-02-28
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.
J. Med. Chem., 61, 2018
6C7Q
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BRD4 BD2 IN COMPLEX WITH COMPOUND CE277
Descriptor:Bromodomain-containing protein 4, 7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-N-(1-methyl-1H-indazol-3-yl)-9H-pyrimido[4,5-b]indol-4-amine
Authors:Meagher, J.L., Stuckey, J.A.
Deposit date:2018-01-23
Release date:2018-08-01
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
J. Med. Chem., 61, 2018
6C7R
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BRD4 BD1 IN COMPLEX WITH COMPOUND CF53
Descriptor:Bromodomain-containing protein 4, N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine
Authors:Meagher, J.L., Stuckey, J.A.
Deposit date:2018-01-23
Release date:2018-08-01
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
J. Med. Chem., 61, 2018
2RBE
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THE DISCOVERY OF 2-ANILINOTHIAZOLONES AS 11BETA-HSD1 INHIBITORS
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhang, J., Jordan, S.R., Li, V.
Deposit date:2007-09-18
Release date:2008-01-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
3BYZ
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2-AMINO-1,3-THIAZOL-4(5H)-ONES AS POTENT AND SELECTIVE 11-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one
Authors:Zhang, J., Jordan, S.R., Li, V.
Deposit date:2008-01-16
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
J.Med.Chem., 51, 2008
4TOT
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CRYSTAL STRUCTURE OF RAT CYCLOPHILIN D IN COMPLEX WITH A POTENT NONIMMUNOSUPPRESSIVE INHIBITOR
Descriptor:Peptidyl-prolyl cis-trans isomerase F, mitochondrial, nonimmunosuppressive inhibitor, ...
Authors:Knapp, M.S., Elling, R.A.
Deposit date:2014-06-06
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
J.Med.Chem., 57, 2014
5NJM
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LYSOZYME ROOM-TEMPERATURE STRUCTURE DETERMINED BY SERIAL MILLISECOND CRYSTALLOGRAPHY
Descriptor:Lysozyme C
Authors:Weinert, T., Vera, L., Marsh, M., James, D., Gashi, D., Nogly, P., Jaeger, K., Standfuss, J.
Deposit date:2017-03-29
Release date:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NLX
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A2A ADENOSINE RECEPTOR ROOM-TEMPERATURE STRUCTURE DETERMINED BY SERIAL MILLISECOND CRYSTALLOGRAPHY
Descriptor:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, OLEIC ACID, SODIUM ION, ...
Authors:Weinert, T., Cheng, R., James, D., Gashi, D., Nogly, P., Jaeger, K., Dore, A.S., Geng, T., Cooke, R., Hennig, M., Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NM2
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A2A ADENOSINE RECEPTOR CRYO STRUCTURE
Descriptor:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ...
Authors:Weinert, T., Cheng, R., James, D., Gashi, D., Nogly, P., Jaeger, K., Dore, A.S., Geng, T., Cooke, R., Hennig, M., Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NM4
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A2A ADENOSINE RECEPTOR ROOM-TEMPERATURE STRUCTURE DETERMINED BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY
Descriptor:Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, OLEIC ACID, SODIUM ION, ...
Authors:Weinert, T., Cheng, R., James, D., Gashi, D., Nogly, P., Jaeger, K., Hennig, M., Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NM5
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TUBULIN DARPIN ROOM-TEMPERATURE STRUCTURE IN COMPLEX WITH COLCHICINE DETERMINED BY SERIAL MILLISECOND CRYSTALLOGRAPHY
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
Authors:Weinert, T., Olieric, N., James, D., Gashi, D., Nogly, P., Jaeger, K., Steinmetz, M.O., Standfuss, J.
Deposit date:2017-04-05
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NQT
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TUBULIN DARPIN ROOM-TEMPERATURE STRUCTURE DETERMINED BY SERIAL MILLISECOND CRYSTALLOGRAPHY
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1, ...
Authors:Weinert, T., Olieric, N., James, D., Gashi, D., Nogly, P., Jaeger, K., Steinmetz, M.O., Standfuss, J.
Deposit date:2017-04-21
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5NQU
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TUBULIN DARPIN CRYO STRUCTURE
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Designed Ankyrin Repeat Protein (DARPIN) D1, ...
Authors:Weinert, T., Olieric, N., James, D., Gashi, D., Nogly, P., Jaeger, K., Steinmetz, M.O., Standfuss, J.
Deposit date:2017-04-21
Release date:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
5O5W
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MOLYBDENUM STORAGE PROTEIN ROOM-TEMPERATURE STRUCTURE DETERMINED BY SERIAL MILLISECOND CRYSTALLOGRAPHY
Descriptor:Molybdenum storage protein subunit alpha, Molybdenum storage protein subunit beta, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Steffen, B., Weinert, T., Ermler, U., Standfuss, J.
Deposit date:2017-06-02
Release date:2017-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.
Nat Commun, 8, 2017
3E9U
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CRYSTAL STRUCTURE OF CALX CBD2 DOMAIN
Descriptor:Na/Ca exchange protein
Authors:Wu, M., Zheng, L.
Deposit date:2008-08-23
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CBD2 from the Drosophila Na(+)/Ca(2+) exchanger: diversity of Ca(2+) regulation and its alternative splicing modification.
J.Mol.Biol., 387, 2009
3PP6
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REP1-NXSQ FATTY ACID TRANSPORTER Y128F MUTANT
Descriptor:ReP1-NCXSQ, PALMITOLEIC ACID
Authors:Berberian, G., Bollo, M., Howard, E., Cousido-Siah, A., Mitschler, A., Ayoub, D., Sanglier-Cianferani, S., Van Dorsselaer, A., DiPolo, R., Beauge, L., Petrova, T., Schulze-Briese, C., Wang, M., Podjarny, A.
Deposit date:2010-11-24
Release date:2011-12-28
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Acta Crystallogr.,Sect.D, 68, 2012
3PPT
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REP1-NXSQ FATTY ACID TRANSPORTER
Descriptor:ReP1-NCXSQ, PALMITOLEIC ACID
Authors:Berberian, G., Bollo, M., Howard, E., Cousido-Siah, A., Mitschler, A., Ayoub, D., Sanglier-Cianferani, S., Van Dorsselaer, A., DiPolo, R., Beauge, L., Petrova, T., Schulze-Briese, C., Wang, M., Podjarny, A.
Deposit date:2010-11-25
Release date:2011-12-21
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Acta Crystallogr.,Sect.D, 68, 2012
4KJR
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CRYSTAL STRUCTURE OF SELENIUM SUBSTITUTED CA2+/H+ ANTIPORTER PROTEINYFKE
Descriptor:cation exchanger YfkE
Authors:Wu, M., Tong, S., Zheng, L.
Deposit date:2013-05-03
Release date:2013-07-03
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation.
Proc.Natl.Acad.Sci.USA, 110, 2013