Author results

5JNW
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CRYSTAL STRUCTURE OF BOVINE LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) MUTANT (W49Y N50E) COMPLEXED WITH VANADATE AND UNCOMPETITIVE INHIBITOR
分子名称:Low molecular weight phosphotyrosine protein phosphatase, VANADATE ION, 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile
著者Stanford, S.M., Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G., Bottini, N.
登録日2016-04-30
公開日2017-03-29
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
5GON
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STRUCTURES OF A BETA-LACTAM BRIDGED ANALOGUE IN COMPLEX WITH TUBULIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Zhou, L., Liu, Y., Cheng, L., Wang, Y.
登録日2016-07-28
公開日2017-03-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016
5UBB
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CRYSTAL STRUCTURE OF HUMAN ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1B
分子名称:Alpha N-terminal protein methyltransferase 1B, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION
著者Dong, C., Zhu, L., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-12-20
公開日2017-03-22
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Commun Biol, 1, 2018
5V00
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STRUCTURE OF HUTD FROM PSEUDOMONAS FLUORESCENS SBW25 (FORMATE CONDITION)
分子名称:Uncharacterized protein, GLYCEROL, FORMIC ACID
著者Liu, Y., Johnston, J.M., Gerth, M.L., Baker, E.N., Lott, J.S., Rainey, P.B.
登録日2017-02-27
公開日2017-03-15
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.
Proteins, 85, 2017
5MF1
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CRYSTAL STRUCTURE OF A C-TERMINALLY TRUNCATED TRIMERIC ECTODOMAIN OF THE CHLAMYDOMONAS REINHARDTII GAMETE FUSION PROTEIN HAP2
分子名称:Fusion protein HAP2/GCS1, N-ACETYL-D-GLUCOSAMINE, N-ACETYL-D-GALACTOSAMINE
著者Fedry, J., Rey, F.A., Krey, T.
登録日2016-11-17
公開日2017-03-08
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein.
Cell, 168, 2017
5T5A
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CRYSTAL STRUCTURE OF THE TWISTER SISTER (TS) RIBOZYME AT 2.0 ANGSTROM
分子名称:DNA/RNA (71-MER), MAGNESIUM ION
著者Lilley, D.M.J., Liu, Y., Wilson, T.J.
登録日2016-08-30
公開日2017-03-08
最終更新日2017-04-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of a nucleolytic ribozyme that employs a catalytic metal ion.
Nat. Chem. Biol., 13, 2017
5UXZ
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X-RAY CRYSTAL STRUCTURE OF HALOTAG BOUND TO THE P9 BENZOTHIADIAZOLE FLUOROGENIC LIGAND
分子名称:Haloalkane dehalogenase, N~2~-{[7-(dimethylamino)-2,1,3-benzothiadiazol-4-yl]sulfonyl}-N-hexyl-N~2~-methylglycinamide, CHLORIDE ION, ...
著者Dunham, N.P., Boal, A.K.
登録日2017-02-23
公開日2017-03-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.
Biochemistry, 56, 2017
5UY1
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X-RAY CRYSTAL STRUCTURE OF APO HALOTAG
分子名称:Haloalkane dehalogenase, 1,2-ETHANEDIOL, CHLORIDE ION
著者Dunham, N.P., Boal, A.K.
登録日2017-02-23
公開日2017-03-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.
Biochemistry, 56, 2017
5IN1
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CRYSTAL STRUCTURE OF THE MRG701 CHROMODOMAIN
分子名称:MRG701, SULFATE ION, 1,2-ETHANEDIOL
著者Huang, Y., Liu, Y.
登録日2016-03-07
公開日2017-03-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants
Protein Cell, 7, 2016
5TA6
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CRYSTAL STRUCTURE OF PLK1 IN COMPLEX WITH A NOVEL 5,6-DIHYDROIMIDAZOLO[1,5-F]PTERIDINE INHIBITOR.
分子名称:Serine/threonine-protein kinase PLK1, 4-{[(6R)-7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ZINC ION
著者Skene, R.J., Hosfield, D.J.
登録日2016-09-09
公開日2017-02-22
最終更新日2017-03-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5TA8
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CRYSTAL STRUCTURE OF PLK1 IN COMPLEX WITH A NOVEL 5,6-DIHYDROIMIDAZOLO[1,5-F]PTERIDINE INHIBITOR
分子名称:Serine/threonine-protein kinase PLK1, ZINC ION, 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
著者Skene, R.J., Hosfield, D.J.
登録日2016-09-09
公開日2017-02-22
最終更新日2017-03-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5H9X
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CRYSTAL STRUCTURE OF GH FAMILY 64 LAMINARIPENTAOSE-PRODUCING BETA-1,3-GLUCANASE FROM PAENIBACILLUS BARENGOLTZII
分子名称:beta-1,3-glucanase
著者Zhen, Q., Yan, Q., Yang, S., Jiang, Z., You, X.
登録日2015-12-29
公開日2017-02-15
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献The recognition mechanism of triple-helical beta-1,3-glucan by a beta-1,3-glucanase
Chem. Commun. (Camb.), 53, 2017
5H9Y
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CRYSTAL STRUCTURE OF GH FAMILY 64 LAMINARIPENTAOSE-PRODUCING BETA-1,3-GLUCANASE FROM PAENIBACILLUS BARENGOLTZII COMPLEXED WITH LAMINARIHEXAOSE.
分子名称:beta-1,3-glucanase, BETA-D-GLUCOSE, L(+)-TARTARIC ACID
著者Zhen, Q., Yan, Q., Yang, S., Jiang, Z., You, X.
登録日2015-12-29
公開日2017-02-15
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.969 Å)
主引用文献The recognition mechanism of triple-helical beta-1,3-glucan by a beta-1,3-glucanase
Chem. Commun. (Camb.), 53, 2017
5HXF
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CRYSTAL STRUCTURE OF 3C PROTEASE FROM A MILD HUMAN ENTEROVIRUS 71 IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protease, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, SULFATE ION
著者Li, B., Yuan, Z., Qin, L., Gu, L.
登録日2016-01-30
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir
To Be Published
5HXG
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STM1697-FLHD COMPLEX
分子名称:Uncharacterized protein STM1697, Flagellar transcriptional regulator FlhD
著者Li, B., Yuan, Z., Qin, L., Gu, L.
登録日2016-01-30
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystal structure of STM1697-FlhD complex
To Be Published
5GSA
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EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
分子名称:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
著者Zhao, K., Zhao, M., Luo, X., Zhang, H.
登録日2016-08-15
公開日2017-02-01
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5HSM
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887
分子名称:Uncharacterized HTH-type transcriptional regulator Rv2887, SULFATE ION
著者Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
登録日2016-01-26
公開日2017-02-01
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5HSO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH DNA
分子名称:Uncharacterized HTH-type transcriptional regulator Rv2887, DNA (30-MER), the upstream sequence of Rv0560c
著者Gao, Y.R., Li, D.F., Wang, D.C., Bi, L.J.
登録日2016-01-26
公開日2017-02-01
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
Sci Rep, 7, 2017
5H19
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR EED162
分子名称:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile
著者Zhao, K., Zhao, M., Luo, X., Zhang, H.
登録日2016-10-08
公開日2017-01-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5H24
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 8
分子名称:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile
著者Zhao, K., Zhao, M., Luo, X., Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5H25
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EED IN COMPLEX WITH PRC2 ALLOSTERIC INHIBITOR COMPOUND 11
分子名称:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
著者Zhao, K., Zhao, M., Luo, X., Zhang, H.
登録日2016-10-14
公開日2017-01-25
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
5TCZ
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NMR SOLUTION STRUCTURE OF ENGINEERED PROTOXIN-II ANALOG
分子名称:Beta/omega-theraphotoxin-Tp2a
著者Gibbs, A.C., Wickenden, A.D.
登録日2016-09-16
公開日2017-01-18
実験手法SOLUTION NMR
主引用文献Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.
Sci Rep, 7, 2017
5GY3
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THE CRYSTAL STRUCTURE OF ENDOGLUCANASE CEL10, A FAMILY 8 GLYCOSYL HYDROLASE FROM KLEBSIELLA PNEUMONIAE
分子名称:Glucanase
著者Attigani, A., Li, S.P., Sun, L.F.
登録日2016-09-21
公開日2016-12-21
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献The crystal structure of the endoglucanase Cel10, a family 8 glycosyl hydrolase from Klebsiella pneumoniae
Acta Crystallogr F Struct Biol Commun, 72, 2016
5M93
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CRYSTAL STRUCTURE OF SDEA-MODIFIED UBIQUITIN.
分子名称:Polyubiquitin-B, SULFATE ION, RIBOSE
著者Kalayil, S., Bhogaraju, S., Dikic, I.
登録日2016-10-31
公開日2016-12-14
実験手法X-RAY DIFFRACTION (1.793 Å)
主引用文献Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination.
Cell, 167, 2016
5EWU
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA C-TERMINAL CHLH AT 1.25A
分子名称:Magnesium-chelatase subunit ChlH, chloroplastic, BENZOIC ACID, ...
著者Chen, Z., Zhang, X., Liu, Y., Jiang, L.
登録日2015-11-21
公開日2016-12-07
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal structure of the Arabidopsis thaliana C-terminal Chlh at 1.25A
To Be Published