Author results

5EWG
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RATP OPPOSITE AN 8-OXODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5F9L
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-12-09
Release date:2016-12-21
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.592 Å)
Cite:Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta
To Be Published
5F9N
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DCMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N2-ETHENODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(GNE)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-12-09
Release date:2016-12-21
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Bypass of the 1, N2-Ethenodeoxyguanosine Lesion by Human DNA Polymerase Eta
To Be Published
5JUM
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DCTP OPPOSITE N-(2'-DEOXYGUANOSIN-8- YL)-3-AMINOBENZANTHRONE (C8-DG-ABA)
Descriptor:DNA polymerase eta, DNA (5'-D(*C*AP*TP*(4E9)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Politica, D.A., Stone, M.P., Egli, M.
Deposit date:2016-05-10
Release date:2016-09-07
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase eta.
Chembiochem, 17, 2016
5L1I
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DCTP OPPOSITE O6-METHYL-2'-DEOXYGUANOSINE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(6OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*C)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2016-07-29
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5L1J
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DTMPNPP OPPOSITE O6-METHYL-2'-DEOXYGUANOSINE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(6OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2016-07-29
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5L1K
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POSTINSERTION COMPLEX OF HUMAN DNA POLYMERASE ETA BYPASSING AN O6-METHYL-2'-DEOXYGUANOSINE : DC SITE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(6OG)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2016-07-29
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5L1L
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POSTINSERTION COMPLEX OF HUMAN DNA POLYMERASE ETA BYPASSING AN O6-METHYL-2'-DEOXYGUANOSINE : DT SITE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(6OG)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2016-07-29
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5SWM
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BACILLUS HALODURANS RNASE H MUTANT D132N IN COMPLEX WITH 12-MER FRNA/DNA HYBRID
Descriptor:Ribonuclease H, RNA (12-MER), DNA (12-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2016-08-08
Release date:2016-09-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'-FRNA:DNA Hybrid.
Biochemistry, 55, 2016
5VAJ
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BHRNASE H - AMIDE-RNA/DNA COMPLEX
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*(URU)P*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), Ribonuclease H, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-27
Release date:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Nucleic Acids Res., 45, 2017
5VBU
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 HYDROXYPROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (9beta)-17-hydroxypregn-4-ene-3,20-dione
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-30
Release date:2017-05-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
J. Biol. Chem., 292, 2017
5W1Z
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CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DECAMER DUPLEX DNA (I4)
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*(BRU)P*IP*I)-3'), MAGNESIUM ION, SODIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-30
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
5W20
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CRYSTAL STRUCTURE OF INOSINE-SUBSTITUTED DUPLEX DNA
Descriptor:DNA (5'-D(*CP*CP*AP*IP*IP*CP*CP*TP*GP*G)-3'), MAGNESIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-06-05
Release date:2017-08-23
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
J. Biomol. Struct. Dyn., 36, 2018
6B82
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ZEBRA FISH CYP-450 17A1 MUTANT ABIRATERONE COMPLEX
Descriptor:Cytochrome P450, family 17, subfamily A, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-10-05
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.
J. Biol. Chem., 293, 2018
6CXZ
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RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U.
Descriptor:RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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RNA OCTAMER CONTAINING 2'-F, 4'-CBETA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY2
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RNA OCTAMER CONTAINING 2'-OME, 4'CALPHA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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RNA OCTAMER CONTAINING 2'-OME, 4'- CBETA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
2Q1O
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
Descriptor:RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGCGAAUUAGCG, WITH A G-A MISMATCH.
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
4I9V
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THE ATOMIC STRUCTURE OF 5-HYDROXYMETHYL 2'-DEOXYCITIDINE BASE PAIRED WITH 2'-DEOXYGUANOSINE IN DICKERSON DREW DODECAMER
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(5HC)P*GP*CP*G)-3'), MAGNESIUM ION, SPERMINE (FULLY PROTONATED FORM)
Authors:Nocek, B., Szulik, M.W., Joachimiak, A., Stone, M.P.
Deposit date:2012-12-05
Release date:2013-11-20
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
6EO6
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X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA-THROMBIN AND MODIFIED 15-MER DNA APTAMER CONTAINING 5-(3-(2-(1H-INDOL-3-YL)ACETAMIDE-N-YL)-1-PROPEN-1-YL)-2'-DEOXYURIDINE RESIDUE
Descriptor:GA63A - TBA MODIFIED APTAMER, Prothrombin, POTASSIUM ION, ...
Authors:Dolot, R.M., Nawrot, B., Yang, X.
Deposit date:2017-10-09
Release date:2017-10-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
6EO7
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X-RAY STRUCTURE OF THE COMPLEX BETWEEN HUMAN ALPHA-THROMBIN AND MODIFIED 15-MER DNA APTAMER CONTAINING 5-(3-(ACETAMIDE-N-YL)-1-PROPEN-1-YL)-2'-DEOXYURIDINE RESIDUE
Descriptor:GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, Prothrombin, POTASSIUM ION, ...
Authors:Dolot, R.M., Nawrot, B., Yang, X.
Deposit date:2017-10-09
Release date:2017-10-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46, 2018
3NGD
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STRUCTURAL BASIS FOR PROFICIENT INCORPORATION OF DTTP OPPOSITE O6-METHYLGUANINE BY HUMAN DNA POLYMERASE IOTA
Descriptor:5'-D(*TP*CP*TP*(6OG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE
Authors:Pence, M.G.
Deposit date:2010-06-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.
J.Biol.Chem., 285, 2010
3OSN
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STRUCTURAL BASIS FOR PROFICIENT INCORPORATION OF DTTP OPPOSITE O6-METHYLGUANINE BY HUMAN DNA POLYMERASE IOTA
Descriptor:5'-D(*TP*CP*TP*(6OG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*(DOC))-3', DNA polymerase iota, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Pence, M.G.
Deposit date:2010-09-09
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.
J.Biol.Chem., 285, 2010