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4RNO
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CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA EXTENDING AN ABASIC SITE-DA PAIR BY INSERTING DCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, Nucleic acids Template: CATG(3DR)TGACGCT, Nucleic acids Primar: AGCGTCAA, ...
Authors:Patra, A., Egli, M.
Deposit date:2014-10-24
Release date:2015-02-18
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 290, 2015
4RU9
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DCMPNPP OPPOSITE A MEFAPY-DG ADDUCTED DNA TEMPLATE
Descriptor:DNA polymerase eta, Nucleic acids Template: CAT(MF7)ATGACGCT, Nucleic acids Primar: AGCGTCAT, ...
Authors:Patra, A., Egli, M.
Deposit date:2014-11-18
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.
J.Am.Chem.Soc., 137, 2015
4RUA
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CRYSTAL STRUCTURE OF Y-FAMILY DNA POLYMERASE DPO4 BYPASSING A MEFAPY-DG ADDUCT
Descriptor:DNA polymerase IV, Nucleic acids Template: TCAT(MF7)GAATCCTTCCCCC, Nucleic acids Primar: GGGGGAAGGATTC, ...
Authors:Patra, A., Banerjee, S., Stone, M.P., Egli, M.
Deposit date:2014-11-18
Release date:2015-08-05
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.
J.Am.Chem.Soc., 137, 2015
4RUC
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CRYSTAL STRUCTURE OF Y-FAMILY DNA POLYMERASE DPO4 EXTENDING FROM A MEFAPY-DG:DC PAIR
Descriptor:DNA polymerase IV, Nucleic acids Template: TCAT(MF7)TAATCCTTCCCCC, Nucleic acids Primar: GGGGGAAGGATTAC, ...
Authors:Patra, A., Banerjee, S., Stone, M.P., Egli, M.
Deposit date:2014-11-18
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.
J.Am.Chem.Soc., 137, 2015
4Y8W
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 PROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Pallan, P.S., Lei, L., Egli, M.
Deposit date:2015-02-16
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
J.Biol.Chem., 290, 2015
4YP3
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YQW
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-13
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.064 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR0
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-13
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR2
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DATP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR3
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(P*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
5C5E
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STRUCTURE OF KAIA DIMER IN COMPLEX WITH C-TERMINAL KAIC PEPTIDE AT 2.8 A RESOLUTION
Descriptor:Circadian clock protein KaiA, KaiC C-terminal peptide, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(sulfanylcarbonyl)amino]benzoic acid
Authors:Pattanayek, R., Egli, M.
Deposit date:2015-06-19
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Protein-Protein Interactions in the Cyanobacterial Circadian Clock: Structure of KaiA Dimer in Complex with C-Terminal KaiC Peptides at 2.8 angstrom Resolution.
Biochemistry, 54, 2015
5DG7
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DTTP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5DG8
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5DG9
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DGMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5DGA
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA EXTENDING AN 1,N6-ETHENODEOXYADENOSINE : DT PAIR BY INSERTING DTMPNPP OPPOSITE TEMPLATE DA
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*AP*(EDA)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5DGB
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA EXTENDING AN 1,N6-ETHENODEOXYADENOSINE : DA PAIR BY INSERTING DTMPNPP OPPOSITE TEMPLATE DA
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*AP*(EDA)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), ...
Authors:Patra, A., Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5DLF
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DATP OPPOSITE O4-METHYLHYMIDINE
Descriptor:DNA polymerase eta, DNA (5'-D(*C*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., OFlaherty, D.K., Egli, M.
Deposit date:2015-09-04
Release date:2016-08-10
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
5DLG
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DGMPNPP OPPOSITE O4-METHYLHYMIDINE
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(5DB)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Patra, A., OFlaherty, D.K., Egli, M.
Deposit date:2015-09-04
Release date:2016-08-10
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
5DO4
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THROMBIN-RNA APTAMER COMPLEX
Descriptor:Thrombin light chain, Thrombin heavy chain, RNA (25-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-14
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
Nucleic Acids Res., 44, 2016
5DO5
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CRYSTAL STRUCTURE OF 2'-FLUORO-RNA BEARING A PHOSPHORODITHIOATE
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(AF2)P*(2SG)P*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate
To Be Published
5DQG
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DAMPNPP OPPOSITE O4-ETHYLTHYMIDINE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(5EJ)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., OFlaherty, D.K., Egli, M.
Deposit date:2015-09-14
Release date:2016-08-10
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
5DQH
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING DGMPNPP OPPOSITE O4-ETHYLTHYMIDINE
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(5EJ)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A., OFlaherty, D.K., Egli, M.
Deposit date:2015-09-14
Release date:2016-08-10
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
5DQI
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CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA EXTENDING AN O4-ETHYLTHYMIDINE : DA PAIR BY INSERTING DCTP OPPOSITE DG
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*(5EJ)P*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*AP*C)-3'), ...
Authors:Patra, A., OFlaherty, D.K., Egli, M.
Deposit date:2015-09-14
Release date:2016-08-10
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Chem Sci, 7, 2016
5EWE
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5EWF
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RCTP OPPOSITE AN 8-OXODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016