4HX1
| Structure of HLA-A68 complexed with a tumor antigen derived peptide | Descriptor: | 9-mer peptide from Tyrosinase-related protein-2, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2012-11-09 | Release date: | 2013-10-02 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
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4I48
| Structure of HLA-A68 complexed with an HIV Env derived peptide | Descriptor: | 9-mer peptide from Envelope glycoprotein gp160, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2012-11-27 | Release date: | 2013-10-02 | Method: | X-RAY DIFFRACTION (2.799 Å) | Cite: | Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
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4HWZ
| Structure of HLA-A68 complexed with an HIV derived peptide | Descriptor: | 9-mer peptide from Pol protein, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. | Deposit date: | 2012-11-09 | Release date: | 2013-10-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.397 Å) | Cite: | Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes Mol.Immunol., 55, 2013
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1CLK
| CRYSTAL STRUCTURE OF STREPTOMYCES DIASTATICUS NO.7 STRAIN M1033 XYLOSE ISOMERASE AT 1.9 A RESOLUTION WITH PSEUDO-I222 SPACE GROUP | Descriptor: | COBALT (II) ION, MAGNESIUM ION, XYLOSE ISOMERASE | Authors: | Niu, L, Teng, M, Zhu, X, Gong, W. | Deposit date: | 1999-04-29 | Release date: | 2000-05-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of xylose isomerase from Streptomyces diastaticus no. 7 strain M1033 at 1.85 A resolution. Acta Crystallogr.,Sect.D, 56, 2000
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1QT1
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1QUA
| CRYSTAL STRUCTURE OF ACUTOLYSIN-C, A HEMORRHAGIC TOXIN FROM THE SNAKE VENOM OF AGKISTRODON ACUTUS, AT 2.2 A RESOLUTION | Descriptor: | ACUTOLYSIN-C, ZINC ION | Authors: | Niu, L, Teng, M, Zhu, X. | Deposit date: | 1999-06-30 | Release date: | 2000-07-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of acutolysin-C, a haemorrhagic toxin from the venom of Agkistrodon acutus, providing further evidence for the mechanism of the pH-dependent proteolytic reaction of zinc metalloproteinases. Acta Crystallogr.,Sect.D, 55, 1999
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7F7W
| JAK2-JH2 | Descriptor: | 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol, Tyrosine-protein kinase JAK2 | Authors: | Niu, L. | Deposit date: | 2021-06-30 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms. Blood Cancer J, 12, 2022
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2EXU
| Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... | Authors: | Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. | Deposit date: | 2005-11-08 | Release date: | 2006-11-08 | Last modified: | 2017-08-23 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain To be published
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4NQ0
| Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones | Descriptor: | HAT1-interacting factor 1 | Authors: | Liu, H, Zhang, M, He, W, Zhu, Z, Teng, M, Gao, Y, Niu, L. | Deposit date: | 2013-11-23 | Release date: | 2014-07-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into yeast histone chaperone Hif1: a scaffold protein recruiting protein complexes to core histones Biochem.J., 462, 2014
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3UBU
| Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet | Descriptor: | Agglucetin subunit alpha-1, Agglucetin subunit beta-2, GLYCEROL, ... | Authors: | Gao, Y, Ge, H, Chen, H, Li, H, Liu, Y, Niu, L, Teng, M. | Deposit date: | 2011-10-25 | Release date: | 2012-04-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins, 2012
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1BUD
| ACUTOLYSIN A FROM SNAKE VENOM OF AGKISTRODON ACUTUS AT PH 5.0 | Descriptor: | CALCIUM ION, PROTEIN (ACUTOLYSIN A), ZINC ION | Authors: | Gong, W, Zhu, X, Liu, S, Teng, M, Niu, L. | Deposit date: | 1998-09-03 | Release date: | 1999-09-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus. J.Mol.Biol., 283, 1998
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1BSW
| ACUTOLYSIN A FROM SNAKE VENOM OF AGKISTRODON ACUTUS AT PH 7.5 | Descriptor: | CALCIUM ION, PROTEIN (ACUTOLYSIN A), ZINC ION | Authors: | Gong, W, Zhu, X, Liu, S, Teng, M, Niu, L. | Deposit date: | 1998-08-31 | Release date: | 1999-08-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus. J.Mol.Biol., 283, 1998
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1OP2
| Crystal Structure of AaV-SP-II, a Glycosylated Snake Venom Serine Proteinase from Agkistrodon acutus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Venom serine proteinase | Authors: | Zhu, Z, Teng, M, Niu, L. | Deposit date: | 2003-03-04 | Release date: | 2004-05-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases J.BIOL.CHEM., 280, 2005
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1OP0
| Crystal Structure of AaV-SP-I, a Glycosylated Snake Venom Serine Proteinase from Agkistrodon acutus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Venom serine proteinase | Authors: | Zhu, Z, Teng, M, Niu, L. | Deposit date: | 2003-03-04 | Release date: | 2004-05-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures and Amidolytic Activities of Two Glycosylated Snake Venom Serine Proteinases J.BIOL.CHEM., 280, 2005
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1WT9
| crystal structure of Aa-X-bp-I, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus | Descriptor: | CALCIUM ION, agkisacutacin A chain, anticoagulant protein-B | Authors: | Zhu, Z, Liu, S, Mo, X, Yu, X, Liang, Z, Zang, J, Zhao, W, Teng, M, Niu, L. | Deposit date: | 2004-11-18 | Release date: | 2006-03-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus To be Published
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1W24
| Crystal Structure Of human Vps29 | Descriptor: | VACUOLAR PROTEIN SORTING PROTEIN 29 | Authors: | Wang, D, Guo, M, Teng, M, Niu, L. | Deposit date: | 2004-06-26 | Release date: | 2005-03-23 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem., 280, 2005
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6J3O
| Crystal structure of the human PCAF bromodomain in complex with compound 12 | Descriptor: | 3-methyl-2-[[(3~{R})-1-methylpiperidin-3-yl]amino]-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone acetyltransferase KAT2B | Authors: | Huang, L.Y, Li, H, Li, L.L, Niu, L, Seupel, R, Wu, C.Y, Li, G.B, Yu, Y.M, Brennan, P.E, Yang, S.Y. | Deposit date: | 2019-01-05 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J.Med.Chem., 62, 2019
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6J3P
| Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n | Descriptor: | 2-{[(3R,5R)-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylpiperidin-3-yl]amino}-3-methyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, Histone acetyltransferase KAT2A | Authors: | Huang, L.Y, Li, H, Niu, L, Wu, C.Y, Yu, Y.M, Li, L.L, Yang, S.Y. | Deposit date: | 2019-01-05 | Release date: | 2019-05-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.598 Å) | Cite: | Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J.Med.Chem., 62, 2019
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1Y17
| crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus | Descriptor: | CALCIUM ION, anticoagulant protein A, anticoagulant protein-B | Authors: | Zhu, Z, Liu, S, Mo, X, Yu, X, Liang, Z, Zang, J, Zhao, W, Teng, M, Niu, L. | Deposit date: | 2004-11-17 | Release date: | 2006-03-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterizations and Crystal structures of two snake venom proteins with the activity of binding coagulation factor X from Agkistrodon acutus To be Published
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1ZVF
| The crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from Saccharomyces cerevisiae | Descriptor: | 3-hydroxyanthranilate 3,4-dioxygenase, NICKEL (II) ION | Authors: | Li, X, Guo, M, Teng, M, Niu, L. | Deposit date: | 2005-06-02 | Release date: | 2006-06-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The crystal structure of 3-hydroxyanthranilate 3,4-dioxygenase from Saccharomyces cerevisiae To be published
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6J71
| HuA21-scFv in complex with the extracellular domain(ECD) of HER2 | Descriptor: | Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, beta-D-mannopyranose, ... | Authors: | Wang, Z, Guo, G, Cheng, B, Zhu, Z, Niu, L, Zhang, H. | Deposit date: | 2019-01-16 | Release date: | 2019-02-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.918 Å) | Cite: | Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells. Acta Crystallogr D Struct Biol, 75, 2019
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4DRA
| Crystal structure of MHF complex | Descriptor: | Centromere protein S, Centromere protein X | Authors: | Tao, Y, Niu, L, Teng, M. | Deposit date: | 2012-02-17 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.414 Å) | Cite: | The structure of the FANCM-MHF complex reveals physical features for functional assembly Nat Commun, 3, 2012
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4DRB
| The crystal structure of FANCM bound MHF complex | Descriptor: | Centromere protein S, Centromere protein X, Fanconi anemia group M protein | Authors: | Tao, Y, Niu, L, Teng, M. | Deposit date: | 2012-02-17 | Release date: | 2012-05-16 | Method: | X-RAY DIFFRACTION (2.634 Å) | Cite: | The structure of the FANCM-MHF complex reveals physical features for functional assembly Nat Commun, 3, 2012
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3H3B
| Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain | Descriptor: | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 | Authors: | Zhou, H, Liu, Y, Niu, L, Zhu, J, Teng, M. | Deposit date: | 2009-04-16 | Release date: | 2010-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21. J.Biol.Chem., 286, 2011
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3B4D
| Crystal Structure of Human PABPN1 RRM | Descriptor: | Polyadenylate-binding protein 2 | Authors: | Ge, H, Tong, S, Teng, M, Niu, L. | Deposit date: | 2007-10-24 | Release date: | 2008-01-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Crystal structure and possible dimerization of the single RRM of human PABPN1 Proteins, 71, 2008
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