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6CVB
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CRYOEM STRUCTURE OF HUMAN ENTEROVIRUS D68 IN COMPLEX WITH 6'-SIALYL-N-ACETYLLACTOSAMINE
Descriptor:viral protein 1, viral protein 3, viral protein 2, ...
Authors:Liu, Y., Rossmann, M.G.
Deposit date:2018-03-27
Release date:2019-07-24
Last modified:2019-07-31
Method:ELECTRON MICROSCOPY (2.43 Å)
Cite:Bypassing pan-enterovirus host factor PLA2G16.
Nat Commun, 10, 2019
6D5F
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CRYO-EM RECONSTRUCTION OF MEMBRANE-ENVELOPED FILAMENTOUS VIRUS SFV1 (SULFOLOBUS FILAMENTOUS VIRUS 1)
Descriptor:Fimbrial protein, DNA (336-MER)
Authors:Wang, F., Osinski, T., Liu, Y., Krupovic, M., Prangishvili, D., Egelman, E.H.
Deposit date:2018-04-19
Release date:2018-08-29
Last modified:2018-09-12
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile.
Nat Commun, 9, 2018
6GRB
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH POTASSIUM
Descriptor:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
Authors:Lilley, D.M.J., Liu, Y., Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRC
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH SODIUM
Descriptor:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
Authors:Lilley, D.M.J., Liu, Y., Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.452 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRD
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH CESIUM
Descriptor:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
Authors:Lilley, D.M.J., Liu, Y., Freeman, D.J.
Deposit date:2018-06-11
Release date:2018-09-26
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
5G06
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CRYO-EM STRUCTURE OF YEAST CYTOPLASMIC EXOSOME
Descriptor:EXOSOME COMPLEX COMPONENT RRP45, EXOSOME COMPLEX COMPONENT SKI6, EXOSOME COMPLEX COMPONENT RRP43, ...
Authors:Liu, J.J., Niu, C.Y., Wu, Y., Tan, D., Wang, Y., Ye, M.D., Liu, Y., Zhao, W.W., Zhou, K., Liu, Q.S., Dai, J.B., Yang, X.R., Dong, M.Q., Huang, N., Wang, H.W.
Deposit date:2016-03-17
Release date:2016-06-15
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
3TI3
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI4
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI5
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI6
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH OSELTAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI8
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIA
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIB
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIC
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
Descriptor:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
Deposit date:2011-08-20
Release date:2011-11-16
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3QWY
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CED-2
Descriptor:Cell death abnormality protein 2, SULFATE ION, GLYCEROL
Authors:Kang, Y., Sun, J., Liu, Y., Sun, D., Hu, Y., Liu, Y.F.
Deposit date:2011-02-28
Release date:2011-06-08
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Biochem.Biophys.Res.Commun., 410, 2011
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
Authors:Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
Deposit date:2017-03-23
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
5YFG
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SOLUTION STRUCTURE OF HUMAN MOG1
Descriptor:Ran guanine nucleotide release factor
Authors:Hu, Q., Liu, Y., Bao, X., Liu, H.
Deposit date:2017-09-21
Release date:2017-11-01
Last modified:2018-04-11
Method:SOLUTION NMR
Cite:Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation
J Mol Cell Biol, 10, 2018
6ABO
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HUMAN XRCC4 AND IFFO1 COMPLEX
Descriptor:DNA repair protein XRCC4, Intermediate filament family orphan 1, GLYCEROL, ...
Authors:Li, J., Liu, L., Liang, H., Liu, Y., Xu, D.
Deposit date:2018-07-23
Release date:2019-07-31
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis.
Nat.Cell Biol., 21, 2019
1M63
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CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
Descriptor:SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, ...
Authors:Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.
Deposit date:2002-07-12
Release date:2002-09-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
Authors:Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
Deposit date:2014-08-22
Release date:2016-02-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
3QWX
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CED-2 1-174
Descriptor:Cell death abnormality protein 2, SULFATE ION
Authors:Kang, Y., Sun, J., Liu, Y.
Deposit date:2011-02-28
Release date:2011-06-08
Last modified:2011-07-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Biochem.Biophys.Res.Commun., 410, 2011
4ZUS
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE REV-QW11
Descriptor:Classical MHC class I antigen, Beta-2-microglobulin, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP
Authors:Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
Deposit date:2015-05-17
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUT
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-GW12
Descriptor:Classical MHC class I antigen, Beta-2-microglobulin, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP
Authors:Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
Deposit date:2015-05-17
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUU
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-CF9
Descriptor:Classical MHC class I antigen, Beta-2-microglobulin, CYS-THR-SER-GLU-GLU-MET-ASN-ALA-PHE
Authors:Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
Deposit date:2015-05-17
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUV
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE ENV-RW12
Descriptor:Classical MHC class I antigen, Beta-2-microglobulin, ARG-VAL-GLU-ASP-VAL-THR-ASN-THR-ALA-GLU-TYR-TRP
Authors:Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
Deposit date:2015-05-17
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016