8GH4
| Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ... | Authors: | Nikolov, D.B, Saha, N, Xu, K, Goldgur, Y. | Deposit date: | 2023-03-09 | Release date: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. Biomed Pharmacother, 161, 2023
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5L0Q
| Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Disintegrin and metalloproteinase domain-containing protein 10, MAGNESIUM ION, ... | Authors: | Xu, K, Saha, N, Nikolov, D.B. | Deposit date: | 2016-07-28 | Release date: | 2016-11-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.759 Å) | Cite: | An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J.Exp.Med., 213, 2016
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4P91
| Crystal structure of the nogo-receptor-2 (27-330) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Reticulon-4 receptor-like 2 | Authors: | Semavina, M, Saha, N, Kolev, M, Goldgur, Y, Giger, R, Himanen, J, Nikolov, D. | Deposit date: | 2014-04-01 | Release date: | 2014-04-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the Nogo-receptor-2. Protein Sci., 20, 2011
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4P8S
| Crystal structure of Nogo-receptor-2 | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Semavina, M, Saha, N, Kolev, M.V, Giger, R.J, Himanen, J.P, Nikolov, D.B. | Deposit date: | 2014-04-01 | Release date: | 2014-04-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the Nogo-receptor-2. Protein Sci., 2011
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2AO7
| Adam10 Disintegrin and cysteine- rich domain | Descriptor: | ADAM 10, SULFATE ION | Authors: | Janes, P.W, Saha, N, Barton, W.A, Kolev, M.V, Wimmer-Kleikamp, S.H, Nievergall, E, Blobel, C.P, Himanen, J.-P, Lackmann, M, Nikolov, D.B. | Deposit date: | 2005-08-12 | Release date: | 2006-08-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell(Cambridge,Mass.), 123, 2005
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6BDZ
| ADAM10 Extracellular Domain Bound by the 11G2 Fab | Descriptor: | 11G2 Fab Heavy Chain, 11G2 Fab Light Chain, CALCIUM ION, ... | Authors: | Seegar, T.C.M. | Deposit date: | 2017-10-24 | Release date: | 2017-12-27 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell, 171, 2017
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6BE6
| ADAM10 Extracellular Domain | Descriptor: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 10, SULFATE ION, ... | Authors: | Seegar, T.C.M. | Deposit date: | 2017-10-24 | Release date: | 2017-12-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell, 171, 2017
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7S7K
| Crystal structure of the EphB2 extracellular domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-B receptor 2, ... | Authors: | Xu, Y, Xu, K, Nikolov, D.B. | Deposit date: | 2021-09-16 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. Int J Mol Sci, 22, 2021
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