Author results

7CUN
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THE STRUCTURE OF HUMAN INTEGRATOR-PP2A COMPLEX
Descriptor:Integrator complex subunit 1, Integrator complex subunit 2, Integrator complex subunit 4, ...
Authors:Zheng, H., Qi, Y., Liu, W., Li, J., Wang, J., Xu, Y.
Deposit date:2020-08-23
Release date:2020-11-25
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Science, 2020
6LAR
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STRUCTURE OF ESX-3 COMPLEX
Descriptor:ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccD3, ESX-3 secretion system protein EccC3, ...
Authors:Wang, S.H., Zhou, K.X., Li, J., Rao, Z.H.
Deposit date:2019-11-13
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:cryo-em structure of esx-3
To Be Published
7CBY
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STRUCTURE OF FOXG1 DNA BINDING DOMAIN BOUND TO DBE2 DNA SITE
Descriptor:DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Forkhead box protein G1, ...
Authors:Dai, S.Y., Li, J., Chen, Y.H.
Deposit date:2020-06-15
Release date:2020-10-28
Method:X-RAY DIFFRACTION (1.646 Å)
Cite:Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations.
J.Mol.Biol., 2020
6JZO
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STRUCTURE OF THE MOUSE TRPC4 ION CHANNEL
Descriptor:Short transient receptor potential channel 4, CHOLESTEROL HEMISUCCINATE, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ...
Authors:Duan, J., Li, Z., Li, J., Zhang, J.
Deposit date:2019-05-03
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structure of the mouse TRPC4 ion channel
To Be Published
7KDT
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HUMAN TOM70 IN COMPLEX WITH SARS COV2 ORF9B
Descriptor:Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Last modified:2020-11-04
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 2020
6LAN
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STRUCTURE OF CCDC50 AND LC3B COMPLEX
Descriptor:Coiled-coil domain-containing protein 50,Microtubule-associated proteins 1A/1B light chain 3B
Authors:Liu, L., Li, J., Hou, P.
Deposit date:2019-11-12
Release date:2020-09-30
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
Cell Res., 2020
7BZB
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CRYSTAL STRUCTURE OF PLANT SESTERTERPENE SYNTHASE ATTPS18
Descriptor:Terpenoid synthase 18, MAGNESIUM ION, PYROPHOSPHATE
Authors:Li, J.X., Wang, G.D., Zhang, P.
Deposit date:2020-04-27
Release date:2020-09-23
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases
Plant Commun., 2020
7BZC
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CRYSTAL STRUCTURE OF PLANT SESTERTERPENE SYNTHASE ATTPS18 COMPLEXED WITH FARNESYL THIOLODIPHOSPHATE (FSPP)
Descriptor:Terpenoid synthase 18, MAGNESIUM ION, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE
Authors:Li, J.X., Wang, G.D., Zhang, P.
Deposit date:2020-04-27
Release date:2020-09-23
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases
Plant Commun., 2020
6M11
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CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH SUNITINIB
Descriptor:Ribonuclease L, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, ...
Authors:Tang, J., Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2020-09-30
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
6M12
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CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH SU11652
Descriptor:Ribonuclease L, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, ...
Authors:Tang, J., Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2020-09-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
6M13
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CRYSTAL STRUCTURE OF RNASE L IN COMPLEX WITH TOCERANIB
Descriptor:Ribonuclease L, 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, ...
Authors:Tang, J., Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2020-09-30
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
7C2Q
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THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE IN THE APO STATE
Descriptor:3C-like proteinase
Authors:Zhou, X.L., Zhong, F.L., Lin, C., Hu, X.H., Zhou, H., Wang, Q.S., Li, j., Zhang, J.
Deposit date:2020-05-08
Release date:2020-09-02
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of COVID-19 main protease in the apo state
To Be Published
7C2Y
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THE CRYSTAL STRUCTURE OF COVID-2019 MAIN PROTEASE IN THE APO STATE
Descriptor:3C-like proteinase
Authors:Zhou, X.L., Zhong, F.L., Lin, C., Zhou, H., Hu, X.H., Wang, Q.S., Li, J., Zhang, J.
Deposit date:2020-05-10
Release date:2020-09-02
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:COVID-2019 main protease in the apo state
To Be Published
7JOU
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CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK1) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR
Descriptor:Rho-associated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide
Authors:Muckelbauer, J.K.
Deposit date:2020-08-07
Release date:2020-09-02
Method:X-RAY DIFFRACTION (3.318 Å)
Cite:Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Bioorg.Med.Chem.Lett., 30, 2020
7JOV
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CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR
Descriptor:Rho-associated protein kinase 2, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide, ...
Authors:Muckelbauer, J.K.
Deposit date:2020-08-07
Release date:2020-09-02
Method:X-RAY DIFFRACTION (2.586 Å)
Cite:Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Bioorg.Med.Chem.Lett., 30, 2020
6M39
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CRYO-EM STRUCTURE OF SADS-COV SPIKE
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Ouyang, S., Hongxin, G.
Deposit date:2020-03-03
Release date:2020-08-26
Last modified:2020-11-11
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Cryo-electron Microscopy Structure of the Swine Acute Diarrhea Syndrome Coronavirus Spike Glycoprotein Provides Insights into Evolution of Unique Coronavirus Spike Proteins.
J.Virol., 94, 2020
6XNB
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THE CRYSTAL STRUCTURE OF THE S154Y MUTANT CARBONYL REDUCTASE FROM LEIFSONIA XYLI EXPLAINS ENHANCED ACTIVITY FOR 3,5-BIS(TRIFLUOROMETHYL)ACETOPHENONE REDUCTION
Descriptor:Short chain alcohol dehydrogenase, MAGNESIUM ION
Authors:Dinh, T., Phillips, R.
Deposit date:2020-07-02
Release date:2020-08-12
Last modified:2020-09-02
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:The Crystal Structure of the S154Y Mutant Carbonyl Reductase from Leifsonia xyli Explains Enhanced Activity for 3,5-Bis(trifluoromethyl)acetophenone Reduction
To Be Published
6KF5
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MICROBIAL HORMONE-SENSITIVE LIPASE E53 MUTANT I256L
Descriptor:Lipase, (4-nitrophenyl) hexanoate, HEXANOIC ACID, ...
Authors:Yang, X., Li, Z.Y., Li, J., Xu, X.W.
Deposit date:2019-07-06
Release date:2020-07-08
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Microbial Hormone-sensitive lipase E53 mutant I256L
To Be Published
6KUZ
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E.COLI BETA-GALACTOSIDASE (E537Q) IN COMPLEX WITH FLUORESCENT PROBE KSL01
Descriptor:Beta-galactosidase, 3-(1,3-benzothiazol-2-yl)-2-[[4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxyphenyl]methoxy]-5-methyl-benzaldehyde, SODIUM ION, ...
Authors:Chen, X., Hu, Y.L., Li, X.K., Guo, Y., Li, J.
Deposit date:2019-09-03
Release date:2020-07-08
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated beta-galactosidase
Chem Sci, 2020
6W0A
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OPEN-GATE KCSA SOAKED IN 1 MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (3.237 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0B
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OPEN-GATE KCSA SOAKED IN 2 MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (3.604 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0C
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OPEN-GATE KCSA SOAKED IN 4 MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (3.556 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0D
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OPEN-GATE KCSA SOAKED IN 5 MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (3.639 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0E
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OPEN-GATE KCSA SOAKED IN 10 MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (3.512 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
6W0F
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CLOSED-GATE KCSA SOAKED IN 0MM KCL/5MM BACL2
Descriptor:Fab Heavy Chain, Fab Light Chain, pH-gated potassium channel KcsA, ...
Authors:Rohaim, A., Gong, L., Li, J.
Deposit date:2020-02-29
Release date:2020-07-08
Last modified:2020-08-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Open and Closed Structures of a Barium-Blocked Potassium Channel.
J.Mol.Biol., 432, 2020
171588
건을2020-11-25부터공개중