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1KT2
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CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IEK BOUND TO MOTH CYTOCHROME C PEPTIDE
Descriptor:H-2 class II histocompatibility antigen, E-D alpha chain, Fusion protein consisting of cytochrome C peptide, ...
Authors:Fremont, D.H., Dai, S., Chiang, H., Crawford, F., Marrack, P., Kappler, J.
Deposit date:2002-01-15
Release date:2002-05-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of cytochrome c presentation by IE(k).
J.Exp.Med., 195, 2002
1KTD
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CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IEK BOUND TO PIGEON CYTOCHROME C PEPTIDE
Descriptor:H-2 class II histocompatibility antigen, E-D alpha chain, Fusion protein consisting of cytochrome C peptide, ...
Authors:Fremont, D.H., Dai, S., Chiang, H., Crawford, F., Marrack, P., Kappler, J.
Deposit date:2002-01-15
Release date:2002-05-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of cytochrome c presentation by IE(k).
J.Exp.Med., 195, 2002
6N2J
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TETRAHYDROPYRIDOPYRIMIDINES AS COVALENT INHIBITORS OF KRAS-G12C
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P.
Deposit date:2018-11-13
Release date:2018-12-12
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett, 9, 2018
6N2K
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TETRAHYDROPYRIDOPYRIMIDINES AS COVALENT INHIBITORS OF KRAS-G12C
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P.
Deposit date:2018-11-13
Release date:2018-12-12
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.
ACS Med Chem Lett, 9, 2018
6USX
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
6USZ
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
6UT0
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IDENTIFICATION OF THE CLINICAL DEVELOPMENT CANDIDATE MRTX849, A COVALENT KRASG12C INHIBITOR FOR THE TREATMENT OF CANCER
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P., Smith, D.J.
Deposit date:2019-10-29
Release date:2020-04-22
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
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