Author results

6NEF
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OUTER MEMBRANE CYTOCHROME S FILAMENT FROM GEOBACTER SULFURREDUCENS
Descriptor:Cytochrome C, PROTOPORPHYRIN IX CONTAINING FE, MAGNESIUM ION
Authors:Filman, D.J., Marino, S.F., Ward, J.E., Yang, L., Mester, Z., Bullitt, E., Lovley, D.R., Strauss, M.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.
Commun Biol, 2, 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6CDP
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VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP20.01 Fab heavy chain, vFP20.01 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDO
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP16.02 Fab heavy chain, vFP16.02 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDM
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP7.04 heavy chain, vFP7.04 light chain, HIV fusion peptide (512-519)
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDI
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CRYO-EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:Glycoprotein gp41, Glycoprotein 120, PGT122 Light Chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6BS2
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 8B
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-12-01
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BRY
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 6A
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-12-01
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BRF
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4B
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-30
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BR1
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4A
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-29
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BG5
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STRUCTURE OF 1-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)-1-(1-PROPYLPIPERIDIN-4-YL)-3-(3-(TRIFLUOROMETHYL)PHENYL)UREA BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6BG3
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STRUCTURE OF (3S,4S)-1-BENZYL-4-(3-(3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PIPERIDIN-3-YL ACETATE BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6AJ9
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1
Descriptor:VL of Fab 11G1, VH of Fab 11G1, VL of Fab 15C5, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ7
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5
Descriptor:VL of Fab 15C5, VH of Fab 15C5, Capsid protein VP1, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ3
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THE STRUCTURE OF ENTEROVIRUS D68 PROCAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ2
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THE STRUCTURE OF ICAM-5 TRIGGERED ENTEROVIRUS D68 VIRUS A-PARTICLE
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ0
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION
Descriptor:Viral protein 1, Virion protein 2, Capsid protein VP3, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-25
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
5ZTM
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CRYSTAL STRUCTURE OF MLE DSRBDS IN COMPLEX WITH ROX2 (R2H1)
Descriptor:Dosage compensation regulator, non-coding mRNA sequence roX2
Authors:Lv, M.Q., Tang, Y.J.
Deposit date:2018-05-04
Release date:2019-03-06
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila.
Nucleic Acids Res., 47, 2019
5ZLU
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RIBOSOME STRUCTURE BOUND TO ABC-F PROTEIN.
Descriptor:RNA (25-mer), 30S ribosomal protein S17, 30S ribosomal protein S18, ...
Authors:Su, W.X., Kumar, V., Ero, R., Andrew, S.W.W., Jian, S., Yong-Gui, G.
Deposit date:2018-03-29
Release date:2018-08-01
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ribosome protection by antibiotic resistance ATP-binding cassette protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ZKQ
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CRYSTAL STRUCTURE OF THE HUMAN PLATELET-ACTIVATING FACTOR RECEPTOR IN COMPLEX WITH ABT-491
Descriptor:Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Cao, C., Zhao, Q., Zhang, X.C., Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
5ZKP
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CRYSTAL STRUCTURE OF THE HUMAN PLATELET-ACTIVATING FACTOR RECEPTOR IN COMPLEX WITH SR 27417
Descriptor:Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, FLAVIN MONONUCLEOTIDE
Authors:Cao, C., Zhao, Q., Zhang, X.C., Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
5YQ7
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CRYO-EM STRUCTURE OF THE RC-LH CORE COMPLEX FROM ROSEIFLEXUS CASTENHOLZII
Descriptor:Beta subunit of light-harvesting 1, Precursor for L subunits of photosynthetic reaction center, Cytochrome subunit of photosynthetic reaction center, ...
Authors:Shi, Y., Xin, Y.Y., Niu, T.X., Wang, Q.Q., Niu, W.Q., Huang, X.J., Ding, W., Blankenship, R.E., Xu, X.L., Sun, F.
Deposit date:2017-11-05
Release date:2018-05-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the RC-LH core complex from an early branching photosynthetic prokaryote.
Nat Commun, 9, 2018