6RZQ
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2E88
| Crystal structure of the human Hsp70 ATPase domain in the apo form | Descriptor: | Heat shock 70kDa protein 1A, ZINC ION | Authors: | Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-01-19 | Release date: | 2008-01-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
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1QQO
| E175S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HYDROLASE (ACTING ON ACID ANHYDRIDES), ... | Authors: | Johnson, E.R, McKay, D.B. | Deposit date: | 1999-06-07 | Release date: | 1999-09-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
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1QQM
| D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... | Authors: | Johnson, E.R, Mckay, D.B. | Deposit date: | 1999-06-07 | Release date: | 1999-09-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
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1QQN
| D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... | Authors: | Johnson, E.R, McKay, D.B. | Deposit date: | 1999-06-07 | Release date: | 1999-09-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
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1S3X
| The crystal structure of the human Hsp70 ATPase domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70 kDa protein 1, ... | Authors: | Sriram, M, Osipiuk, J, Freeman, B, Morimoto, R.I, Joachimiak, A. | Deposit date: | 2004-01-14 | Release date: | 2004-01-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure, 5, 1997
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4R5K
| Crystal structure of the DnaK C-terminus (Dnak-SBD-B) | Descriptor: | CALCIUM ION, Chaperone protein DnaK, SULFATE ION | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7469 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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4R5J
| Crystal structure of the DnaK C-terminus (Dnak-SBD-A) | Descriptor: | CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.361 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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4R5L
| Crystal structure of the DnaK C-terminus (Dnak-SBD-C) | Descriptor: | CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION, ... | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9701 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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4R5I
| Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG | Descriptor: | Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9702 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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4R5G
| Crystal structure of the DnaK C-terminus with the inhibitor PET-16 | Descriptor: | Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium | Authors: | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | Deposit date: | 2014-08-21 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.4501 Å) | Cite: | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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1U00
| HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC | Descriptor: | Chaperone protein hscA, IscU recognition peptide | Authors: | Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. | Deposit date: | 2004-07-12 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
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5XI9
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5XIR
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3ATV
| Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ... | Authors: | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-01-13 | Release date: | 2011-12-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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3ATU
| Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ... | Authors: | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-01-13 | Release date: | 2011-12-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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6ASY
| BiP-ATP2 | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. | Deposit date: | 2017-08-26 | Release date: | 2017-12-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
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6B1N
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3AY9
| Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... | Authors: | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2011-05-03 | Release date: | 2011-12-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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6B1I
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6B1M
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3C7N
| Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ... | Authors: | Schuermann, J.P, Jiang, J, Hart, P.J, Sousa, R. | Deposit date: | 2008-02-07 | Release date: | 2008-05-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.115 Å) | Cite: | Structure of the Hsp110:Hsc70 nucleotide exchange machine Mol.Cell, 31, 2008
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3D2E
| Crystal structure of a complex of Sse1p and Hsp70, Selenomethionine-labeled crystals | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Heat shock 70 kDa protein 1, ... | Authors: | Polier, S, Bracher, A. | Deposit date: | 2008-05-08 | Release date: | 2008-06-17 | Last modified: | 2017-07-26 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell(Cambridge,Mass.), 133, 2008
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6G3S
| Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Second structure of two TEW-HSP70 structures deposited. | Descriptor: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | Authors: | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | Deposit date: | 2018-03-26 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
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6G3R
| Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Structure one of two TEW-HSP70 structures deposited. | Descriptor: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | Authors: | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | Deposit date: | 2018-03-26 | Release date: | 2018-10-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms. PLoS ONE, 13, 2018
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