4R5G

Crystal structure of the DnaK C-terminus with the inhibitor PET-16

Summary for 4R5G

Entry DOI	10.2210/pdb4r5g/pdb
Descriptor	Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium (3 entities in total)
Functional Keywords	helical bundle, beta sheets, chaperone, hsp70/dnak inhibitors, membrane, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Escherichia coli
Cellular location	Cytoplasm : P0A6Y8
Total number of polymer chains	2
Total formula weight	50838.16
Authors	Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. (deposition date: 2014-08-21, release date: 2014-09-10, Last modification date: 2023-09-20)
Primary citation	Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9:2508-2516, 2014 Cited by PubMed: 25148104 DOI: 10.1021/cb500236y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4501 Å)

Structure validation