4R5I

Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG

Summary for 4R5I

Entry DOI	10.2210/pdb4r5i/pdb
Descriptor	Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, SULFATE ION, ... (5 entities in total)
Functional Keywords	helical bundle, beta sheets, chaperone, substrate binding, membrane
Biological source	Escherichia coli More
Cellular location	Cytoplasm : P0A6Y8
Total number of polymer chains	2
Total formula weight	26692.39
Authors	Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. (deposition date: 2014-08-21, release date: 2014-09-10, Last modification date: 2024-02-28)
Primary citation	Leu, J.I.,Zhang, P.,Murphy, M.E.,Marmorstein, R.,George, D.L. Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9:2508-2516, 2014 Cited by PubMed: 25148104 DOI: 10.1021/cb500236y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9702 Å)

Structure validation