1ZZ0
| Crystal structure of a HDAC-like protein with acetate bound | Descriptor: | ACETATE ION, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... | Authors: | Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. | Deposit date: | 2005-06-13 | Release date: | 2005-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
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1ZZ3
| Crystal structure of a HDAC-like protein with CypX bound | Descriptor: | 3-CYCLOPENTYL-N-HYDROXYPROPANAMIDE, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... | Authors: | Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. | Deposit date: | 2005-06-13 | Release date: | 2005-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
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1ZZ1
| Crystal structure of a HDAC-like protein with SAHA bound | Descriptor: | Histone deacetylase-like amidohydrolase, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, POTASSIUM ION, ... | Authors: | Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. | Deposit date: | 2005-06-13 | Release date: | 2005-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
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5WGM
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ACY-1083 | Descriptor: | 1,2-ETHANEDIOL, 2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Porter, N.J, Christianson, D.W. | Deposit date: | 2017-07-14 | Release date: | 2017-12-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WGK
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5WGL
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5ZOO
| Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP1 fragment | Descriptor: | Histone deacetylase 4, POTASSIUM ION, SMRT corepressor SP1 fragment, ... | Authors: | Park, S.Y, Hwang, H.J, Kim, J.S. | Deposit date: | 2018-04-13 | Release date: | 2018-11-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. Nucleic Acids Res., 46, 2018
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5ZOP
| Crystal structure of histone deacetylase 4 (HDAC4) in complex with a SMRT corepressor SP2 fragment | Descriptor: | Histone deacetylase 4, POTASSIUM ION, SMRT corepressor SP2 fragment, ... | Authors: | Park, S.Y, Hwang, H.J, Kim, J.S. | Deposit date: | 2018-04-13 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. Nucleic Acids Res., 46, 2018
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5ZMP
| The structure of a lysine deacylase | Descriptor: | ZINC ION, lysine deacylase | Authors: | Ge, F. | Deposit date: | 2018-04-05 | Release date: | 2019-02-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | The structure of a lysine deacylase To Be Published
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3MAX
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3MEN
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3MZ6
| Crystal structure of D101L Fe2+ HDAC8 complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, FE (II) ION, Histone deacetylase 8, ... | Authors: | Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2010-05-11 | Release date: | 2010-06-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
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3MZ7
| Crystal structure of D101L Co2+ HDAC8 complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, GLYCEROL, ... | Authors: | Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2010-05-11 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
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3MZ3
| Crystal structure of Co2+ HDAC8 complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, COBALT (II) ION, Histone deacetylase 8, ... | Authors: | Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2010-05-11 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
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3MZ4
| Crystal structure of D101L Mn2+ HDAC8 complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... | Authors: | Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2010-05-11 | Release date: | 2010-06-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
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7UK2
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NN-390 | Descriptor: | Hdac6 protein, N-hydroxy-4-{[(propan-2-yl)(2,3,4,5-tetrafluorobenzene-1-sulfonyl)amino]methyl}benzamide, POTASSIUM ION, ... | Authors: | Erdogan, F, Seo, H.-S, Dhe-Paganon, S. | Deposit date: | 2022-03-31 | Release date: | 2022-11-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma. Pharmaceuticals, 15, 2022
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3Q9E
| Crystal structure of H159A APAH complexed with acetylspermine | Descriptor: | Acetylpolyamine amidohydrolase, N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide, POTASSIUM ION, ... | Authors: | Lombardi, P.M, Christianson, D.W. | Deposit date: | 2011-01-07 | Release date: | 2011-03-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
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3Q9F
| Crystal Structure of APAH complexed with CAPS | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Acetylpolyamine amidohydrolase, PHOSPHATE ION, ... | Authors: | Lombardi, P.M, Christianson, D.W. | Deposit date: | 2011-01-07 | Release date: | 2011-03-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
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3Q9B
| Crystal Structure of APAH complexed with M344 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Acetylpolyamine amidohydrolase, DIMETHYL SULFOXIDE, ... | Authors: | Lombardi, P.M, Christianson, D.W. | Deposit date: | 2011-01-07 | Release date: | 2011-03-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases . Biochemistry, 50, 2011
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7WJL
| Crystal structure of S. cerevisiae Hos3 | Descriptor: | ACETATE ION, Histone deacetylase HOS3, ZINC ION | Authors: | Pang, N.N, Che, S.Y, Yang, N. | Deposit date: | 2022-01-07 | Release date: | 2023-01-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural characterization of fungus-specific histone deacetylase Hos3 provides insights into developing selective inhibitors with antifungal activity. J.Biol.Chem., 298, 2022
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3EWF
| Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate. | Descriptor: | 7-AMINO-4-METHYL-CHROMEN-2-ONE, Histone deacetylase 8, PEPTIDIC SUBSTRATE, ... | Authors: | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2008-10-14 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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3F06
| Crystal Structure Analysis of Human HDAC8 D101A Variant. | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, Histone deacetylase 8, ... | Authors: | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2008-10-24 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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3EZT
| Crystal Structure Analysis of Human HDAC8 D101E Variant | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, Histone deacetylase 8, ... | Authors: | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2008-10-23 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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3F07
| Crystal Structure Analysis of Human HDAC8 complexed with APHA in a new monoclinic crystal form | Descriptor: | (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide, Histone deacetylase 8, POTASSIUM ION, ... | Authors: | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | Deposit date: | 2008-10-24 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
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3Q9C
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