3MZ4

Crystal structure of D101L Mn2+ HDAC8 complexed with M344

Summary for 3MZ4

Entry DOI	10.2210/pdb3mz4/pdb
Related	1T67 3EW8 3MZ3 3MZ6 3MZ7
Descriptor	Histone deacetylase 8, MANGANESE (II) ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	hydrolase, metallohydrolase, managanese(ii), arginase-like
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9BY41
Total number of polymer chains	2
Total formula weight	87525.36
Authors	Dowling, D.P.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2010-05-11, release date: 2010-06-23, Last modification date: 2024-02-21)
Primary citation	Dowling, D.P.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49:5048-5056, 2010 Cited by PubMed: 20545365 DOI: 10.1021/bi1005046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.845 Å)

Structure validation