Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3EW8

Crystal Structure Analysis of human HDAC8 D101L variant

Summary for 3EW8
Entry DOI10.2210/pdb3ew8/pdb
Related2V5W 3EWF
DescriptorHistone deacetylase 8, POTASSIUM ION, ZINC ION, ... (7 entities in total)
Functional Keywordshydrolase, hdac, metalloenzyme, arginase fold, hdac8, histone deacetylase, hydroxamate inhibitor, unliganded, chromatin regulator, nucleus, repressor, transcription, transcription regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: Q9BY41
Total number of polymer chains1
Total formula weight43978.42
Authors
Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-14, release date: 2008-12-30, Last modification date: 2023-09-06)
Primary citationDowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W.
Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
Biochemistry, 47:13554-13563, 2008
Cited by
PubMed: 19053282
DOI: 10.1021/bi801610c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon