3EW8
Crystal Structure Analysis of human HDAC8 D101L variant
Summary for 3EW8
Entry DOI | 10.2210/pdb3ew8/pdb |
Related | 2V5W 3EWF |
Descriptor | Histone deacetylase 8, POTASSIUM ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | hydrolase, hdac, metalloenzyme, arginase fold, hdac8, histone deacetylase, hydroxamate inhibitor, unliganded, chromatin regulator, nucleus, repressor, transcription, transcription regulation |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9BY41 |
Total number of polymer chains | 1 |
Total formula weight | 43978.42 |
Authors | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-14, release date: 2008-12-30, Last modification date: 2023-09-06) |
Primary citation | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47:13554-13563, 2008 Cited by PubMed: 19053282DOI: 10.1021/bi801610c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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