3EWF
Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate.
Summary for 3EWF
Entry DOI | 10.2210/pdb3ewf/pdb |
Related | 2V5W 3EW8 |
Descriptor | Histone deacetylase 8, PEPTIDIC SUBSTRATE, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, hdac, metalloenzyme, acetylation, arginase fold, hdac8, histone deacetylase, substrate complex, alternative splicing, chromatin regulator, nucleus, repressor, transcription, transcription regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 176556.72 |
Authors | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-14, release date: 2008-12-30, Last modification date: 2023-11-15) |
Primary citation | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47:13554-13563, 2008 Cited by PubMed: 19053282DOI: 10.1021/bi801610c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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