3EWF

Crystal Structure Analysis of human HDAC8 H143A variant complexed with substrate.

Summary for 3EWF

• Entry DOI: 10.2210/pdb3ewf/pdb
• Related: 2V5W 3EW8
• Descriptor: Histone deacetylase 8, PEPTIDIC SUBSTRATE, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase, hdac, metalloenzyme, acetylation, arginase fold, hdac8, histone deacetylase, substrate complex, alternative splicing, chromatin regulator, nucleus, repressor, transcription, transcription regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 176556.72

Authors

Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-14, release date: 2008-12-30, Last modification date: 2023-11-15)

• Primary citation: Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W.; Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.; Biochemistry, 47:13554-13563, 2008; PubMed: 19053282; DOI: 10.1021/bi801610c

Experimental method

X-RAY DIFFRACTION (2.5 Å)