7W57
 
 | | Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7W55
 | | Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7W56
 | | Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7W53
 | | Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | You, C, Xu, H.E, Jiang, Y. | | 登録日 | 2021-11-29 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-06-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
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7VQX
 | | Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | | 登録日 | 2021-10-21 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.
Nat Commun, 13, 2022
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7VIG
 | | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | | 分子名称: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | | 登録日 | 2021-09-26 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIF
 | | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | | 分子名称: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | | 登録日 | 2021-09-26 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIE
 | | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | | 登録日 | 2021-09-26 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIH
 | | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | | 分子名称: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | | 登録日 | 2021-09-26 | | 公開日 | 2022-09-28 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VFX
 | | The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | | 登録日 | 2021-09-14 | | 公開日 | 2022-09-21 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun, 13, 2022
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7W40
 | | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers | | 分子名称: | Bombesin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhan, Y, Peng, S, Zhang, H. | | 登録日 | 2021-11-26 | | 公開日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7W3Z
 | | Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers | | 分子名称: | Gastrin Releasing Peptide PRGNHWAVGHLM(NH2), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhan, Y, Peng, S, Zhang, H. | | 登録日 | 2021-11-26 | | 公開日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7WU9
 | | Cryo-EM structure of the human EP3-Gi signaling complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Suno, R, Sugita, Y, Morimoto, K, Iwasaki, K, Kato, T, Kobayashi, T. | | 登録日 | 2022-02-07 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.375 Å) | | 主引用文献 | Structural insights into the G protein selectivity revealed by the human EP3-G i signaling complex.
Cell Rep, 40, 2022
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7WF7
 | | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | He, Y, Xu, Z. | | 登録日 | 2021-12-26 | | 公開日 | 2022-01-05 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
Nat.Chem.Biol., 18, 2022
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7WVW
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | | 分子名称: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVY
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVX
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVU
 | | Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | | 分子名称: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVV
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | | 分子名称: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WQ4
 | | Galanin-bound galanin receptor 2 in complex with Gq | | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | | 登録日 | 2022-01-24 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
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7WUJ
 | | Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | | 分子名称: | Adhesion G-protein coupled receptor G4,Uncharacterized protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Guo, S.C, Huang, S.M, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | | 登録日 | 2022-02-08 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Nature, 604, 2022
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7WQ3
 | | Galanin-bound galanin receptor 1 in complex with Gi | | 分子名称: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | | 著者 | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | | 登録日 | 2022-01-24 | | 公開日 | 2022-04-20 | | 最終更新日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
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7WUI
 | | Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | | 分子名称: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Guo, S.C, He, Q.T, Xiao, P, Sun, J.P, Yu, X. | | 登録日 | 2022-02-08 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Nature, 604, 2022
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7WU4
 | | Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGi | | 分子名称: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | | 登録日 | 2022-02-05 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1.
Nature, 604, 2022
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7WU5
 | | Cryo-EM structure of the adhesion GPCR ADGRF1(H565A/T567A) in complex with miniGi | | 分子名称: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | | 登録日 | 2022-02-05 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-05-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1.
Nature, 604, 2022
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