PDB: 876 件ウェブページステータス検索Chemie searchBIRD

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6M1H	CryoEM structure of human PAC1 receptor in complex with maxadilan 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6M1I	CryoEM structure of human PAC1 receptor in complex with PACAP38 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6M8S	Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits 分子名称: BTB/POZ domain-containing protein KCTD12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 著者 Zheng, S, Kruse, A.C. 登録日 2018-08-22 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 Structural basis for KCTD-mediated rapid desensitization of GABABsignalling. Nature, 567, 2019
6N9G	Crystal Structure of RGS7-Gbeta5 dimer 分子名称: Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 著者 Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. 登録日 2018-12-03 公開日 2019-01-09 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.129 Å) 主引用文献 Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex. Elife, 7, 2018
6N4B	Cannabinoid Receptor 1-G Protein Complex 分子名称: CHOLESTEROL, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Krishna Kumar, K, Shalev-Benami, M, Hu, H, Weis, W.I, Kobilka, B.K, Skiniotis, G. 登録日 2018-11-18 公開日 2019-01-30 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex. Cell, 176, 2019
6NBI	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein 分子名称: CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. 登録日 2018-12-07 公開日 2019-04-17 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
6NBH	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein 分子名称: CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. 登録日 2018-12-07 公開日 2019-04-17 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
6NI3	B2V2R-Gs protein subcomplex of a GPCR-G protein-beta-arrestin mega-complex 分子名称: 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Endolysin,Beta-2 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Nguyen, A.H, Thomsen, A.R.B, Cahill, T.J, des Georges, A, Lefkowitz, R.J. 登録日 2018-12-26 公開日 2019-11-20 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex. Nat.Struct.Mol.Biol., 26, 2019
6NIY	A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex 分子名称: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M. 登録日 2019-01-02 公開日 2019-01-23 最終更新日 2020-04-08 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 The Molecular Control of Calcitonin Receptor Signaling. Acs Pharmacol Transl Sci, 2, 2019
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747 分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2019-09-02 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
6NBF	Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein 分子名称: CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. 登録日 2018-12-07 公開日 2019-04-17 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
6UUS	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-31 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6UVA	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide 分子名称: Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-11-01 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6OIJ	Muscarinic acetylcholine receptor 1-G11 protein complex 分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, CHOLESTEROL HEMISUCCINATE, ... 著者 Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. 登録日 2019-04-09 公開日 2019-05-08 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
6OYA	Structure of the Rhodopsin-Transducin-Nanobody Complex 分子名称: Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G. 登録日 2019-05-14 公開日 2019-07-24 最終更新日 2019-12-04 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Mol.Cell, 75, 2019
6OSA	human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. 登録日 2019-05-01 公開日 2019-07-10 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
6OS9	human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. 登録日 2019-05-01 公開日 2019-07-10 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
6UUN	CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-30 公開日 2020-03-25 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6OT0	Structure of human Smoothened-Gi complex 分子名称: 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-3-OL, Fab heavy chain, Fab light chain, ... 著者 Qi, X, Li, X. 登録日 2019-05-02 公開日 2019-06-12 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi. Nature, 571, 2019
6OIK	Muscarinic acetylcholine receptor 2-Go complex 分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ... 著者 Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. 登録日 2019-04-09 公開日 2019-05-08 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
6VCB	Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator 分子名称: 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... 著者 Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K. 登録日 2019-12-20 公開日 2020-07-22 最終更新日 2020-09-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat.Chem.Biol., 16, 2020
6ORV	Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor 分子名称: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Danev, R. 登録日 2019-05-01 公開日 2020-01-08 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577, 2020
6VN7	Cryo-EM structure of an activated VIP1 receptor-G protein complex 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Duan, J, Shen, D.-D, Zhou, X.E, Liu, Q.-F, Zhuang, Y.-W, Zhang, H.-B, Xu, P.-Y, Ma, S.-S, He, X.-H, Melcher, K, Zhang, Y, Xu, H.E, Yi, J. 登録日 2020-01-29 公開日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun, 11, 2020
6OMM	Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. 登録日 2019-04-19 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
6OY9	Structure of the Rhodopsin-Transducin Complex 分子名称: Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... 著者 Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G. 登録日 2019-05-14 公開日 2019-07-24 最終更新日 2019-12-04 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation. Mol.Cell, 75, 2019

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