PDB: 293 件ウェブページステータス検索Chemie searchBIRD

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7N28	Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ... 著者 Zhou, T, Gao, F. 登録日 2021-05-28 公開日 2022-04-06 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci, 9, 2022
7N6W	Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U2 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhang, S, Wang, K, Mao, Y. 登録日 2021-06-09 公開日 2021-09-22 最終更新日 2021-12-08 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
7N6U	Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U1 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhang, S, Wang, K, Mao, Y. 登録日 2021-06-09 公開日 2021-09-22 最終更新日 2021-12-08 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
7MDU	BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RM20A3 mAb Heavy Chain, ... 著者 Antanasijevic, A, Ward, A.B. 登録日 2021-04-06 公開日 2022-01-26 最終更新日 2022-02-02 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 From structure to sequence: Antibody discovery using cryoEM. Sci Adv, 8, 2022
7MDT	BG505 SOSIP.v5.2 in complex with the monoclonal antibody Rh4O9.8 (as Fab fragment) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Rh4O9.8 monoclonal antibody Heavy Chain, ... 著者 Antanasijevic, A, Ozorowski, G, Nogal, B, Ward, A.B. 登録日 2021-04-06 公開日 2022-01-26 最終更新日 2022-02-02 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 From structure to sequence: Antibody discovery using cryoEM. Sci Adv, 8, 2022
7N65	Complex structure of HIV superinfection Fab QA013.2 and BG505.SOSIP.664 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp41, ... 著者 Mangala Prasad, V, Shipley, M.M, Overbaugh, J.M, Lee, K.K. 登録日 2021-06-07 公開日 2021-07-28 実験手法 ELECTRON MICROSCOPY (4.15 Å) 主引用文献 Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection. Elife, 10, 2021
6X5B	Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with small molecule GO52 分子名称: 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Ozorowski, G, Torres, J.L, Ward, A.B. 登録日 2020-05-25 公開日 2020-10-21 最終更新日 2020-12-09 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide. Cell Rep, 33, 2020
6X9S	HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in stable CHO cells in complex with RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2020-06-03 公開日 2020-11-04 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
6X9R	HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293F cells in complex with RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2020-06-03 公開日 2020-11-04 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
6X9T	HIV-1 Envelope Glycoprotein BG505 SOSIP.664 expressed in HEK293S cells in complex with RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2020-06-03 公開日 2020-11-04 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
6X96	Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 10A fragment antigen binding variable domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 HIV-1 Env gp120, ... 著者 Ozorowski, G, Cottrell, C.A, Ward, A.B. 登録日 2020-06-02 公開日 2021-12-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions To Be Published
6X98	Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11B fragment antigen binding variable domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 HIV-1 Env gp120, ... 著者 Ozorowski, G, Cottrell, C.A, Ward, A.B. 登録日 2020-06-02 公開日 2021-12-08 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions To Be Published
6X97	Cryo-EM model of HIV-1 Env BG505 SOSIP.664 in complex with rabbit monoclonal antibody 11A fragment antigen binding variable domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 HIV-1 Env gp120, ... 著者 Ozorowski, G, Cottrell, C.A, Ward, A.B. 登録日 2020-06-02 公開日 2021-12-08 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 Limited breadth of anti-HIV Env glycan hole antibodies is further hindered by strain-specific peptide interactions To Be Published
6X9V	HIV-1 Envelope Glycoprotein BG505 SOSIP.664, expressed in HEK293S cells and deglycosylated by endoglycosidase H, in complex with RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2020-06-03 公開日 2020-11-04 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
6X9U	HIV-1 Envelope Glycoprotein BG505 SOSIP.664, expressed in HEK293S cells and partially deglycosylated by endoglycosidase H, in complex with RM20A3 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp120, ... 著者 Berndsen, Z.T, Ward, A.B. 登録日 2020-06-03 公開日 2020-11-04 最終更新日 2020-11-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Visualization of the HIV-1 Env glycan shield across scales. Proc.Natl.Acad.Sci.USA, 117, 2020
6XRT	Cryo-EM structure of SHIV-elicited RHA1.V2.01 in complex with HIV-1 Env BG505 DS-SOSIP.664 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Gorman, J, Kwong, P.D. 登録日 2020-07-13 公開日 2020-10-07 最終更新日 2021-01-20 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science, 371, 2021
5U7O	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom 分子名称: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pancera, M, Lai, Y.-T, Kwong, P.D. 登録日 2016-12-12 公開日 2017-08-30 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.031 Å) 主引用文献 Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat. Chem. Biol., 13, 2017
5U7M	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom 分子名称: 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pancera, M, Lai, Y.-T, Kwong, P.D. 登録日 2016-12-12 公開日 2017-08-30 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.025 Å) 主引用文献 Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat. Chem. Biol., 13, 2017
5T3S	HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Stanfield, R.L, Wilson, I.A. 登録日 2016-08-26 公開日 2016-09-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity, 45, 2016
5T3Z	3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074 分子名称: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gristick, H.B, Bjorkman, P.J. 登録日 2016-08-26 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat.Struct.Mol.Biol., 23, 2016
6B0N	Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp140, ... 著者 Sarkar, A, Irimia, A, Wilson, I.A. 登録日 2017-09-14 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer. Nat Commun, 9, 2018
5THR	Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex 分子名称: 17b Fab VH domain, 17b Fab VL domain, 8ANC195 G52K5 VH domain, ... 著者 Wang, H, Bjorkman, P.J. 登録日 2016-09-30 公開日 2016-11-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc.Natl.Acad.Sci.USA, 113, 2016
6CDI	Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... 著者 Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. 登録日 2018-02-08 公開日 2018-05-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
6CE0	Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... 著者 Kumar, S, Sarkar, A, Wilson, I.A. 登録日 2018-02-09 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.602 Å) 主引用文献 HIV-1 vaccine design through minimizing envelope metastability. Sci Adv, 4, 2018
6CH7	XFEL crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barnes, C.O, Bjorkman, P.J. 登録日 2018-02-22 公開日 2018-05-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope. Nat Commun, 9, 2018

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