7N28

Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env

Summary for 7N28

• Entry DOI: 10.2210/pdb7n28/pdb
• EMDB information: 24071 24128
• Descriptor: Envelope glycoprotein gp120, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (17 entities in total)
• Functional Keywords: hiv-1, siv-1, v2-apex, envelope glycoprotein, neutralizing antibody, glycan-dependent, immune system-viral protein complex, immune system/viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 14
• Total formula weight: 439208.36

Authors

Zhou, T.,Gao, F. (deposition date: 2021-05-28, release date: 2022-04-06, Last modification date: 2022-06-22)

• Primary citation: Gao, N.,Gai, Y.,Meng, L.,Wang, C.,Wang, W.,Li, X.,Gu, T.,Louder, M.K.,Doria-Rose, N.A.,Wiehe, K.,Nazzari, A.F.,Olia, A.S.,Gorman, J.,Rawi, R.,Wu, W.,Smith, C.,Khant, H.,de Val, N.,Yu, B.,Luo, J.,Niu, H.,Tsybovsky, Y.,Liao, H.,Kepler, T.B.,Kwong, P.D.,Mascola, J.R.,Qin, C.,Zhou, T.,Yu, X.,Gao, F.; Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.; Adv Sci, 9:e2200063-e2200063, 2022; PubMed: 35319830; DOI: 10.1002/advs.202200063

Experimental method

ELECTRON MICROSCOPY (4.2 Å)