PDB: 2396 件ウェブページステータス検索Chemie searchBIRD

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8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain 分子名称: Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-10-20 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8F0E	N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit 分子名称: Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2022-11-02 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8EWX	N-terminal WD40 domain of beta'-COPI subunit with two chains in the asymmetric unit 分子名称: Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2022-10-24 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8ENW	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 clientized spike tail heptapeptide. 分子名称: 1,2-ETHANEDIOL, Clientized spike tail peptide, Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2022-09-30 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENY	Crystal structure of alpha-COPI-WD40 domain R13A mutant. 分子名称: ACETYL GROUP, Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-09-30 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENS	Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide 分子名称: Coatomer subunit beta', spike tail hepta-peptide 著者 Dey, D, Hasan, S.S. 登録日 2022-09-30 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENZ	Crystal structure of alpha-COPI-WD40 domain K15A mutant. 分子名称: ACETYL GROUP, Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-09-30 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8EO0	Crystal structure of alpha-COPI WD40 domain R300A mutant. 分子名称: ACETYL GROUP, Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-10-01 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8ENX	Crystal structure of beta'-COPI-WD40 domain Y33A mutant in complex with SARS-CoV-2 clientized spike tail heptapeptide. 分子名称: Clientized spike tail heptapeptide, Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2022-09-30 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8G3C	Crystal structure of human WDR5 in complex with N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide (compound 1, WDR5-MYC PPI inhibitor) 分子名称: N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-3-hydroxy-6-methyl-4-oxo-4H-pyran-2-carboxamide, WD repeat-containing protein 5 著者 Zhao, M. 登録日 2023-02-07 公開日 2023-06-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8G3E	Crystal structure of human WDR5 in complex with (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide (compound 2, WDR5-MYC inhibitor) 分子名称: (1M)-N-[(3,5-difluoro[1,1'-biphenyl]-4-yl)methyl]-6-methyl-4-oxo-1-(pyridin-3-yl)-1,4-dihydropyridazine-3-carboxamide, WD repeat-containing protein 5 著者 Zhao, M. 登録日 2023-02-07 公開日 2023-06-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction. J.Med.Chem., 66, 2023
8Q1N	Cyclic peptide binder of the WBM-site of WDR5 分子名称: Cyclic peptide inhibitor, WD repeat-containing protein 5 著者 Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. 登録日 2023-08-01 公開日 2023-09-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.843 Å) 主引用文献 Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59, 2023
8SIU	Origin Recognition Complex Associated (ORCA) protein bound to Orc2 分子名称: Leucine-rich repeat and WD repeat-containing protein 1, Origin recognition complex subunit 2, SULFATE ION 著者 Bleichert, F, Ekundayo, B.E. 登録日 2023-04-17 公開日 2023-08-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin. Embo J., 42, 2023
8SZX	Crystal structure of b'-WD40 Lys17Ala mutant 分子名称: Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2023-05-30 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023
8T5I	Crystal structure of human WDR5 in complex with MR4397 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide, ... 著者 Kimani, S, Dong, A, Li, F, Loppnau, P, Ackloo, S, Vedadi, M, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2023-06-13 公開日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human WDR5 in complex with MR4397 To be published
8UJY	Crystal structure of human WD repeat-containing protein 5 in complex with 4-(3,5-dimethoxybenzyl)-9-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (compound 8) 分子名称: (9P)-4-[(3,5-dimethoxyphenyl)methyl]-9-(4-fluoro-2-methylphenyl)-7-{[(2E)-2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl]methyl}-3,4-dihydro-1,4-benzoxazepin-5(2H)-one, WD repeat-containing protein 5 著者 Zhao, B, Amporndanai, K, Fesik, S.W. 登録日 2023-10-11 公開日 2023-12-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors. J.Med.Chem., 66, 2023
7WVK	Crystal structure of human WDR5 in complex with compound 19 分子名称: 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... 著者 Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. 登録日 2022-02-10 公開日 2022-10-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
8HMX	WDR5 in complex with histone H3Q5his peptide 分子名称: WD repeat-containing protein 5, histone H3Q5his peptide 著者 Li, H.T, Zhao, S, Wang, H.F. 登録日 2022-12-06 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 WDR5 in complex with histone H3Q5his peptide To Be Published
8HQX	The complex structure of COPI cargo sorting module with TAT-WDM peptide 分子名称: Coatomer subunit beta', TAT-WDM KxKxx motif 著者 Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. 登録日 2022-12-14 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.538 Å) 主引用文献 The complex structure of COPI cargo sorting module with TAT-WDM peptide To Be Published
8HQW	The complex structure of COPI cargo sorting module with MHV Spike Hxx sorting motif 分子名称: Coatomer subunit beta',MHV Spike Hxx sorting motif 著者 Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. 登録日 2022-12-14 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.405 Å) 主引用文献 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQV	The complex structure of COPI cargo sorting module with HCoV-OC43 Spike KTSHxx sorting motif 分子名称: Coatomer subunit beta', HCoV-OC43 Spike KTSHxx sorting motif 著者 Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. 登録日 2022-12-14 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.398 Å) 主引用文献 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
8HQT	The complex structure of COPI cargo sorting module with SARS-CoV-2 Spike KxHxx sorting motif 分子名称: Coatomer subunit beta', SARS-CoV-2 Spike KxHxx motif 著者 Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. 登録日 2022-12-14 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
1A0R	HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA 分子名称: FARNESYL, PHOSDUCIN, TRANSDUCIN (BETA SUBUNIT), ... 著者 Loew, A, Ho, Y.-K, Blundell, T.L, Bax, B. 登録日 1997-12-05 公開日 1998-12-30 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Phosducin induces a structural change in transducin beta gamma. Structure, 6, 1998
2I3S	Bub3 complex with Bub1 GLEBS motif 分子名称: Cell cycle arrest protein, Checkpoint serine/threonine-protein kinase 著者 Larsen, N.A, Harrison, S.C. 登録日 2006-08-20 公開日 2007-01-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc.Natl.Acad.Sci.Usa, 104, 2007
2I3T	Bub3 complex with Mad3 (BubR1) GLEBS motif 分子名称: Cell cycle arrest protein, Spindle assembly checkpoint component 著者 Larsen, N.A, Harrison, S.C. 登録日 2006-08-20 公開日 2007-01-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc.Natl.Acad.Sci.Usa, 104, 2007

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