PDB: 2396 件ウェブページステータス検索Chemie searchBIRD

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6PG5	WDR5delta32 bound to benzyl (4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, benzyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide 分子名称: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG3	WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol 分子名称: (2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol 分子名称: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol 分子名称: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6QTS	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTR	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTT	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTQ	Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTX	Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription factor homolog 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTV	Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTO	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTW	Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor 分子名称: Cryptochrome-1, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTU	Crystal structure of Arabidopsis WD40 domain in complex with a BBX transcription factor 分子名称: B-box zinc finger protein 24, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6R60	asymmetric antiparallel assembly of two 5-bladed beta-propeller fragments 分子名称: WD-40 repeat protein 著者 Afanasieva, E, Lupas, A.N, Hartmann, M.D. 登録日 2019-03-26 公開日 2019-11-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5Z	9-bladed beta-propeller formed by three 3-bladed fragments 分子名称: 9-bladed beta-propeller formed by three 3-bladed fragments 著者 Martin, J, Lupas, A.N, Hartmann, M.D. 登録日 2019-03-26 公開日 2019-11-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5X	8-bladed beta-propeller formed by four 2-bladed fragments 分子名称: WD-40 repeat protein 著者 Martin, J, Lupas, A.N, Hartmann, M.D. 登録日 2019-03-25 公開日 2019-11-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6R5Y	8-bladed beta-propeller formed by two 4-bladed fragments 分子名称: WD-40 repeat protein, ZINC ION 著者 Martin, J, Lupas, A.N, Hartmann, M.D. 登録日 2019-03-25 公開日 2019-11-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural diversity of oligomeric beta-propellers with different numbers of identical blades. Elife, 8, 2019
6SFC	EED in complex with a methyl-thiazole 分子名称: CALCIUM ION, N-(1,3-benzodioxol-4-ylmethyl)-4-methyl-5-(1-methylpyrazol-3-yl)-1,3-thiazol-2-amine, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Read, J.A. 登録日 2019-08-01 公開日 2019-09-25 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Rapid Identification of Novel Allosteric PRC2 Inhibitors. Acs Chem.Biol., 14, 2019
6YVI	EED in complex with a cyano-benzofuran 分子名称: 5-fluoranyl-4-[[[8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]methyl]-2,3-dihydro-1-benzofuran-7-carbonitrile, CALCIUM ION, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Read, J.A. 登録日 2020-04-28 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
6YVJ	EED in complex with a triazolopyrimidine 分子名称: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Read, J.A. 登録日 2020-04-28 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
7AXU	Structure of WDR5:CS-VIP8 cocrystal after illumination in situ 分子名称: WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXQ	Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K 分子名称: CS-VIP8, WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.562 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022

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