4BWF
| Pex4p-Pex22p disulphide bond mutant | Descriptor: | 1,2-ETHANEDIOL, PEROXISOME ASSEMBLY PROTEIN 22, UBIQUITIN-CONJUGATING ENZYME E2-21 KDA | Authors: | Williams, C, van den Berg, M, Stanley, W.A, Wilmanns, M, Distel, B. | Deposit date: | 2013-07-01 | Release date: | 2013-07-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | A Disulphide Bond in the E2 Enzyme Pex4P Modulates Ubiquitin-Conjugating Activity Sci.Rep., 3, 2013
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2NVU
| Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ... | Authors: | Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A. | Deposit date: | 2006-11-13 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature, 445, 2007
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4BVU
| Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate | Descriptor: | PROTEIN KINASE OSPG, UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2 D3 | Authors: | Pruneda, J.N, LeTrong, I, Stenkamp, R.E, Klevit, R.E, Brzovic, P.S. | Deposit date: | 2013-06-28 | Release date: | 2014-01-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | E2~Ub Conjugates Regulate the Kinase Activity of Shigella Effector Ospg During Pathogenesis. Embo J., 33, 2014
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4CCG
| Structure of an E2-E3 complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CHLORIDE ION, ... | Authors: | Hodson, C, Purkiss, A, Walden, H. | Deposit date: | 2013-10-22 | Release date: | 2014-01-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Human Fancl Ring-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection. Structure, 22, 2014
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2O25
| Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9 | Descriptor: | SUMO-1-conjugating enzyme UBC9, Ubiquitin-conjugating enzyme E2-25 kDa | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-29 | Release date: | 2007-01-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Novel and Unexpected Complex Between the SUMO-1-Conjugating Enzyme UBC9 and the Ubiquitin-Conjugating Enzyme E2-25 kDa To be Published
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2OXQ
| Structure of the UbcH5 :CHIP U-box complex | Descriptor: | CHLORIDE ION, STIP1 homology and U-Box containing protein 1, Ubiquitin-conjugating enzyme E2D 1 | Authors: | Xu, Z, Nix, J.C, Devlin, K.I, Misra, S. | Deposit date: | 2007-02-20 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes. Bmc Struct.Biol., 8, 2008
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2PE6
| Non-covalent complex between human SUMO-1 and human Ubc9 | Descriptor: | SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1 | Authors: | Capili, A.D, Lima, C.D. | Deposit date: | 2007-04-02 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction. J.Mol.Biol., 369, 2007
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2PX9
| The intrinsic affinity between E2 and the Cys domain of E1 in Ubiquitin-like modifications | Descriptor: | SUMO-activating enzyme subunit 2, SUMO-conjugating enzyme UBC9 | Authors: | Wang, J.H, Hu, W.D, Cai, S, Lee, B, Song, J, Chen, Y. | Deposit date: | 2007-05-14 | Release date: | 2007-07-24 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The intrinsic affinity between E2 and the Cys domain of E1 in ubiquitin-like modifications. Mol.Cell, 27, 2007
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2PWQ
| Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii | Descriptor: | Ubiquitin conjugating enzyme | Authors: | Qiu, W, Dong, A, Hassanali, A, Lin, L, Brokx, S, Altamentova, S, Hills, T, Lew, J, Ravichandran, M, Kozieradzki, I, Zhao, Y, Schapira, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2007-05-11 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii. To be Published
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7K5J
| Structure of an E1-E2-ubiquitin thioester mimetic | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | Authors: | Yuan, L, Lv, Z, Olsen, S.K. | Deposit date: | 2020-09-16 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification. Nat Commun, 12, 2021
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7KZV
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7KZS
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7KZR
| Structure of the human Fanconi Anaemia Core-UBE2T-ID complex | Descriptor: | E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, Fanconi anemia core complex-associated protein 20, ... | Authors: | Wang, S.L, Pavletich, N.P. | Deposit date: | 2020-12-10 | Release date: | 2021-03-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021
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7KZT
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7M2K
| CDC34A-Ubiquitin-2ab inhibitor complex | Descriptor: | 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 | Authors: | Ceccarelli, D.F, St-Cyr, D, Tyers, M, Sicheri, F. | Deposit date: | 2021-03-16 | Release date: | 2021-11-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex. Sci Adv, 7, 2021
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7MYH
| Ubiquitin variant UbV.k.2 in complex with Ube2k | Descriptor: | GLYCEROL, Ubiquitin variant UbV.k.2, Ubiquitin-conjugating enzyme E2 K | Authors: | Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. | Deposit date: | 2021-05-21 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.394 Å) | Cite: | Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
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7MYF
| Ubiquitin variant UbV.k.1 in complex with Ube2k | Descriptor: | Ubiquitin, Ubiquitin variant UbV.k.1, Ubiquitin-conjugating enzyme E2 K | Authors: | Middleton, A.J, Day, C.L, Teyra, J, Sidhu, S.S. | Deposit date: | 2021-05-21 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k. Acs Chem.Biol., 16, 2021
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7MEY
| Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron | Descriptor: | 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
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7MEX
| Structure of yeast Ubr1 in complex with Ubc2 and N-degron | Descriptor: | E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... | Authors: | Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-04-08 | Release date: | 2021-11-24 | Last modified: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
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6ZHT
| Uba1-Ubc13 disulfide mediated complex | Descriptor: | CHLORIDE ION, GLYCEROL, Ubiquitin-activating enzyme E1 1, ... | Authors: | Schaefer, A, Misra, M, Schindelin, H. | Deposit date: | 2020-06-23 | Release date: | 2022-01-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system. To Be Published
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6ZHU
| Yeast Uba1 in complex with Ubc3 and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ubiquitin-activating enzyme E1 1, ... | Authors: | Misra, M, Schindelin, H. | Deposit date: | 2020-06-23 | Release date: | 2022-01-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system To Be Published
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6ZHS
| Uba1 bound to two E2 (Ubc13) molecules | Descriptor: | GLYCEROL, SULFATE ION, Ubiquitin-activating enzyme E1 1, ... | Authors: | Misra, M, Schindelin, H. | Deposit date: | 2020-06-23 | Release date: | 2022-01-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system. To Be Published
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7AI0
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7AI1
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7AHZ
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