PDB: 259 resultsInfo pagesStatus searchChemie searchBIRD

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8SZ8	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state (full helix) Descriptor: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-05-27 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8SZ4	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state showing the PH domain Descriptor: Dynamin-1 Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-05-26 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8T0K	Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state Descriptor: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-06-01 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8SZ7	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state showing the second PH domain Descriptor: Dynamin-1 Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-05-27 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.84 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8SXZ	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state Descriptor: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-05-24 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8T0R	Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state (full helix) Descriptor: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION Authors: Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. Deposit date: 2023-06-01 Release date: 2024-05-01 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.97 Å) Cite: Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8S93	Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase Descriptor: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... Authors: Lin, D.Y, Andreotti, A.H. Deposit date: 2023-03-27 Release date: 2023-08-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
1B55	PH DOMAIN FROM BRUTON'S TYROSINE KINASE IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE Descriptor: INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, TYROSINE-PROTEIN KINASE BTK, ZINC ION Authors: Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A.M, Potter, B.V.L, O'Brien, R, Ladbury, J.E, Saraste, M. Deposit date: 1999-01-12 Release date: 1999-06-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BWN	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4 Descriptor: BRUTON'S TYROSINE KINASE, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ZINC ION Authors: Djinovic Carugo, K, Baraldi, E, Hyvoenen, M, Lo Surdo, P, Riley, A, Potter, B, Saraste, M. Deposit date: 1998-09-25 Release date: 1999-06-15 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure Fold.Des., 7, 1999
1BTK	PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT R28C Descriptor: BRUTON'S TYROSINE KINASE, SODIUM ION, ZINC ION Authors: Hyvonen, M, Saraste, M. Deposit date: 1997-07-01 Release date: 1997-09-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. EMBO J., 16, 1997
4F7H	The crystal structure of kindlin-2 pleckstrin homology domain in free form Descriptor: Fermitin family homolog 2, S,R MESO-TARTARIC ACID Authors: Liu, Y, Zhu, Y, Qin, J, Ye, S, Zhang, R. Deposit date: 2012-05-16 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation. Protein Cell, 3, 2012
1NTY	Crystal structure of the first DH/PH domain of Trio to 1.7 A Descriptor: Triple functional domain protein Authors: Skowronek, K.R, Zheng, Y, Nassar, N. Deposit date: 2003-01-30 Release date: 2004-06-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J.Biol.Chem., 279, 2004
4GMV	Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin Descriptor: Ras-associated and pleckstrin homology domains-containing protein 1 Authors: Chang, Y.C.E, Wu, J. Deposit date: 2012-08-16 Release date: 2012-11-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.403 Å) Cite: Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell, 4, 2013
1DBH	DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 Descriptor: PROTEIN (HUMAN SOS 1) Authors: Soisson, S.M, Kuriyan, J. Deposit date: 1998-12-17 Release date: 1998-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell(Cambridge,Mass.), 95, 1998
4GN1	Crystal Structure of the RA and PH domains of Lamellipodin Descriptor: MALONATE ION, Ras-associated and pleckstrin homology domains-containing protein 1 Authors: Chang, Y.C.E, Wu, J. Deposit date: 2012-08-16 Release date: 2012-11-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell, 4, 2013
4GZU	Crystal structure of the DH-PH-PH domain of FARP2 Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 2 Authors: He, X, Zhang, X. Deposit date: 2012-09-06 Release date: 2013-03-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4H6Y	Crystal structure of the DH-PH-PH domain of FARP1 Descriptor: FERM, RhoGEF and pleckstrin domain-containing protein 1 Authors: He, X, Zhang, X. Deposit date: 2012-09-19 Release date: 2013-03-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.09 Å) Cite: Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4H8S	Crystal structure of human APPL2BARPH domain Descriptor: DCC-interacting protein 13-beta Authors: Martin, J.L, King, G.J. Deposit date: 2012-09-23 Release date: 2012-10-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase. J.Biol.Chem., 287, 2012
2Q13	Crystal structure of BAR-PH domain of APPL1 Descriptor: DCC-interacting protein 13 alpha Authors: Zhu, G, Zhang, X.C. Deposit date: 2007-05-23 Release date: 2007-08-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. Embo J., 26, 2007
2R09	Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Cytohesin-3, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... Authors: DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G. Deposit date: 2007-08-17 Release date: 2007-12-04 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell, 28, 2007
2R0D	Crystal Structure of Autoinhibited Form of Grp1 Arf GTPase Exchange Factor Descriptor: Cytohesin-3, DI(HYDROXYETHYL)ETHER, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, ... Authors: DiNitto, J.P, Delprato, A, Gabe Lee, M.T, Cronin, T.C, Huang, S, Guilherme, A, Czech, M.P, Lambright, D.G. Deposit date: 2007-08-18 Release date: 2007-12-04 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange Factors. Mol.Cell, 28, 2007
3KSY	Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS) Descriptor: Son of sevenless homolog 1 Authors: Gureasko, J, Kuchment, O, Kuriyan, J. Deposit date: 2009-11-24 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.178 Å) Cite: Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc.Natl.Acad.Sci.USA, 107, 2010
4K2O	The Structure of a Triple Mutant of the Tiam1 PH-CC-Ex Domain Descriptor: T-lymphoma invasion and metastasis-inducing protein 1 Authors: Joshi, M, Gakhar, L, Fuentes, E.J. Deposit date: 2013-04-09 Release date: 2013-07-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr.,Sect.F, 69, 2013
4K2P	The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain Descriptor: CALCIUM ION, T-lymphoma invasion and metastasis-inducing protein 1 Authors: Joshi, M, Gakhar, L, Fuentes, E.J. Deposit date: 2013-04-09 Release date: 2013-07-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.98 Å) Cite: High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr.,Sect.F, 69, 2013
3LJU	Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3 Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION Authors: Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2010-01-26 Release date: 2010-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.702 Å) Cite: Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107, 2010

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