PDB: 729 resultsInfo pagesStatus searchChemie searchBIRD

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4QAH	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. Deposit date: 2014-05-05 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.403 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QUN	Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant Descriptor: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-11 Release date: 2014-12-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4QUM	Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide Descriptor: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-10 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.516 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4RDD	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. Deposit date: 2014-09-18 Release date: 2015-07-01 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
4RH5	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RH9	Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.598 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RHG	Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-02 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI4	Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate Descriptor: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.596 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI5	Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4S0G	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide Descriptor: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-12-31 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.723 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
7KEY	Protein Tyrosine Phosphatase 1B, Apo Descriptor: ACETATE ION, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Battaile, K.P, Chirgadze, Y, Ruzanov, M, Romanov, V, Lam, K, Gordon, R, Lin, A, Lam, R, Pai, E, Chirgadze, N. Deposit date: 2020-10-13 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.771 Å) Cite: Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. J.Biomol.Struct.Dyn., 2021
7L0C	Ligand-free PTP1B T177G Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Shen, R.D, Hengge, A.C, Johnson, S.J. Deposit date: 2020-12-11 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
7L0I	Ligand-free YopH G352T Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein-tyrosine-phosphatase Authors: Shen, R.D, Hengge, A.C, Johnson, S.J. Deposit date: 2020-12-11 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
7L0M	Vanadate-bound YopH G352T Descriptor: Protein-tyrosine-phosphatase, VANADATE ION Authors: Shen, R.D, Hengge, A.C, Johnson, S.J. Deposit date: 2020-12-11 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
7L0H	Vanadate-bound PTP1B T177G Descriptor: Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION Authors: Shen, R.D, Hengge, A.C, Johnson, S.J. Deposit date: 2020-12-11 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
7KLX	Protein Tyrosine Phosphatase 1B with inhibitor Descriptor: 2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic acid, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Battaile, K.P, Chirgadze, Y, Ruzanov, M, Romanov, V, Lam, K, Gordon, R, Lin, A, Lam, R, Pai, E, Chirgadze, N. Deposit date: 2020-11-01 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.839 Å) Cite: Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. J.Biomol.Struct.Dyn., 2021
7LFO	Protein Tyrosine Phosphatase 1B Descriptor: MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J.M. Deposit date: 2021-01-18 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products. Acs Synth Biol, 10, 2021
7MM1	PTP1B in complex with TCS401 by Native S-SAD at Room Temperature Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Greisman, J.B, Dalton, K.M, Hekstra, D.R. Deposit date: 2021-04-29 Release date: 2021-05-12 Last modified: 2022-08-17 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Native SAD phasing at room temperature. Acta Crystallogr D Struct Biol, 78, 2022
7MPC	Structure of SsoPTP bound to vanadate Descriptor: SsoPTP, VANADATE ION Authors: Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. Deposit date: 2021-05-04 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality. Biochemistry, 60, 2021
7MPD	Structure of SsoPTP bound to 2-chloroethylsulfonate Descriptor: 2-chloroethane-1-sulfonic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SsoPTP Authors: Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. Deposit date: 2021-05-04 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality. Biochemistry, 60, 2021
7MNA	PTP1B 1-284 F225Y-R199N in complex with TCS401 Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Torgeson, K.R, Page, R, Peti, W. Deposit date: 2021-04-30 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
7MN7	PTP1B F225Y in complex with TCS401 Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... Authors: Torgeson, K.R, Page, R, Peti, W. Deposit date: 2021-04-30 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
7MNE	PTP1B P206G mutation, open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Torgeson, K.R, Page, R, Peti, W. Deposit date: 2021-04-30 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
7MKZ	PTP1B F225Y mutant, open state Descriptor: CHLORIDE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Torgeson, K.R, Page, R, Peti, W. Deposit date: 2021-04-27 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022
7MNC	PTP1B L204A Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 1 Authors: Torgeson, K.R, Page, R, Peti, W. Deposit date: 2021-04-30 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Conserved conformational dynamics determine enzyme activity. Sci Adv, 8, 2022

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