4QUM
Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide
Summary for 4QUM
Entry DOI | 10.2210/pdb4qum/pdb |
Related | 1CM8 2B49 4QUN |
Descriptor | Tyrosine-protein phosphatase non-receptor type 3, Mitogen-activated protein kinase 12 (3 entities in total) |
Functional Keywords | alpha beta, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 36131.92 |
Authors | Chen, K.E.,Meng, T.C.,Wang, A.H.J. (deposition date: 2014-07-10, release date: 2014-12-10, Last modification date: 2023-12-06) |
Primary citation | Chen, K.E.,Lin, S.Y.,Wu, M.J.,Ho, M.R.,Santhanam, A.,Chou, C.C.,Meng, T.C.,Wang, A.H.J. Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7:ra98-ra98, 2014 Cited by PubMed: 25314968DOI: 10.1126/scisignal.2005722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.516 Å) |
Structure validation
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