PDB: 4816 resultsInfo pagesStatus searchChemie searchBIRD

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1NA7	Crystal structure of the catalytic subunit of human protein kinase CK2 Descriptor: Casein kinase II, alpha chain Authors: Pechkova, E, Zanotti, G, Nicolini, C. Deposit date: 2002-11-27 Release date: 2003-08-26 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. Acta Crystallogr.,Sect.D, 59, 2003
1NVQ	The Complex Structure Of Checkpoint Kinase Chk1/UCN-01 Descriptor: 7-HYDROXYSTAUROSPORINE, Peptide ASVSA, SULFATE ION, ... Authors: Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B. Deposit date: 2003-02-04 Release date: 2003-04-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Chk1 Inhibition by UCN-01 J.Biol.Chem., 277, 2002
1NVR	The Complex Structure Of Checkpoint Kinase Chk1/Staurosporine Descriptor: Peptide ASVSA, STAUROSPORINE, SULFATE ION, ... Authors: Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B. Deposit date: 2003-02-04 Release date: 2003-04-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis for Chk1 Inhibition by UCN-01 J.Biol.Chem., 277, 2002
1NVS	The Complex Structure Of Checkpoint Kinase Chk1/SB218078 Descriptor: Peptide ASVSA, REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE, SULFATE ION, ... Authors: Zhao, B, Bower, M.J, McDevitt, P.J, Zhao, H, Davis, S.T, Johanson, K.O, Green, S.M, Concha, N.O, Zhou, B.B. Deposit date: 2003-02-04 Release date: 2003-04-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis for Chk1 Inhibition by UCN-01 J.Biol.Chem., 277, 2002
1NXK	Crystal structure of staurosporine bound to MAP KAP kinase 2 Descriptor: MAP kinase-activated protein kinase 2, STAUROSPORINE, SULFATE ION Authors: Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Czerwinski, R.M, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. Deposit date: 2003-02-10 Release date: 2003-10-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme Structure, 11, 2003
1NY3	Crystal structure of ADP bound to MAP KAP kinase 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAP kinase-activated protein kinase 2 Authors: Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Maguire, M, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. Deposit date: 2003-02-11 Release date: 2003-10-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3 Å) Cite: Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme Structure, 11, 2003
1O6K	Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP Descriptor: GLYCOGEN SYNTHASE KINASE-3 BETA, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Yang, J, Cron, P, Good, V.M, Thompson, V, Hemmings, B.A, Barford, D. Deposit date: 2002-10-08 Release date: 2002-11-19 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp Nat.Struct.Biol., 9, 2002
1O6L	Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide Descriptor: GLYCOGEN SYNTHASE KINASE-3 BETA, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Yang, J, Cron, P, Good, V.M, Thompson, V, Hemmings, B.A, Barford, D. Deposit date: 2002-10-08 Release date: 2002-11-19 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of an Activated Akt/Protein Kinase B Ternary Complex with Gsk-3 Peptide and AMP-Pnp Nat.Struct.Biol., 9, 2002
1O6Y	Catalytic domain of PknB kinase from Mycobacterium tuberculosis Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SERINE/THREONINE-PROTEIN KINASE PKNB Authors: Ortiz-Lombardia, M, Pompeo, F, Boitel, B, Alzari, P.M, TB Structural Genomics Consortium (TBSGC) Deposit date: 2002-10-21 Release date: 2003-01-30 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the Catalytic Domain of the Pknb Serine/Threonine Kinase from Mycobacterium Tuberculosis J.Biol.Chem., 278, 2003
1O9U	GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE Descriptor: 9-METHYL-9H-PURIN-6-AMINE, AXIN PEPTIDE, GLYCOGEN SYNTHASE KINASE-3 BETA Authors: Dajani, R, Pearl, L.H, Roe, S.M. Deposit date: 2002-12-19 Release date: 2003-08-15 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Basis for Recruitment of Glycogen Synthase Kinase 3Beta to the Axin-Apc Scaffold Complex Embo J., 22, 2003
1OB3	Structure of P. falciparum PfPK5 Descriptor: CELL DIVISION CONTROL PROTEIN 2 HOMOLOG Authors: Holton, S, Merckx, A, Burgess, D, Doerig, C, Noble, M, Endicott, J. Deposit date: 2003-01-24 Release date: 2004-01-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of P. Falciparum Pfpk5 Test the Cdk Regulation Paradigm and Suggest Mechanisms of Small Molecule Inhibition Structure, 11, 2003
1OGU	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR Descriptor: 4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: Pratt, D.J, Endicott, J.A, Noble, M.E.M. Deposit date: 2003-05-13 Release date: 2003-09-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Based Design of 2-Arylamino-4-Cyclohexyl Methyl-5-Nitroso-6-Aminopyrimidine Inhibitors of Cyclin-Dependent Kinases 1 and 2 Bioorg.Med.Chem.Lett., 13, 2003
1OI9	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor Descriptor: 6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: Pratt, D.J, Endicott, J.A, Noble, M.E.M. Deposit date: 2003-06-10 Release date: 2004-07-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
1OIQ	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation Descriptor: CELL DIVISION PROTEIN KINASE 2, N-[4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)-2-PYRIMIDINYL]ACETAMIDE Authors: Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J. Deposit date: 2003-06-24 Release date: 2003-09-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation Bioorg.Med.Chem.Lett., 13, 2003
1OIR	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation Descriptor: 1-(DIMETHYLAMINO)-3-(4-{{4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL, CELL DIVISION PROTEIN KINASE 2 Authors: Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J. Deposit date: 2003-06-24 Release date: 2003-09-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation Bioorg.Med.Chem.Lett., 13, 2003
1OIT	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation Descriptor: 4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 Authors: Beattie, J.F, Breault, G.A, Byth, K.F, Culshaw, J.D, Ellston, R.P.A, Green, S, Minshull, C.A, Norman, R.A, Pauptit, R.A, Thomas, A.P, Jewsbury, P.J. Deposit date: 2003-06-24 Release date: 2003-09-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Imidazo[1,2-A]Pyridines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors Identified Through Structure-Based Hybridisation Bioorg.Med.Chem.Lett., 13, 2003
1OIU	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor Descriptor: 3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: Pratt, D.J, Endicott, J.A, Noble, M.E.M. Deposit date: 2003-06-26 Release date: 2004-07-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
1OIY	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor Descriptor: 4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... Authors: Pratt, D.J, Endicott, J.A, Noble, M.E.M. Deposit date: 2003-06-26 Release date: 2004-07-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: N2-Substituted O6-Cyclohexylmethylguanine Derivatives: Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2 J.Med.Chem., 47, 2004
1OKV	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2 Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, H-ARG-ARG-LEU-ILE-PHE-NH2 Authors: Kontopidis, G, Andrews, M, McInnes, C, Cowan, A, Powers, H, Innes, L, Plater, A, Griffiths, G, Paterson, D, Zheleva, D, Lane, D, Green, S, Walkinshaw, M, Fischer, P. Deposit date: 2003-07-30 Release date: 2003-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange Structure, 11, 2003
1OKW	Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2 Descriptor: ACE-ARG-ARG-LEU-ASN-FCL-NH2, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 Authors: Kontopidis, G, Andrews, M, McInnes, C, Cowan, A, Powers, H, Innes, L, Plater, A, Griffiths, G, Paterson, D, Zheleva, D, Lane, D, Green, S, Walkinshaw, M, Fischer, P. Deposit date: 2003-07-31 Release date: 2003-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange Structure, 11, 2003
1OKY	Structure of human PDK1 kinase domain in complex with staurosporine Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, STAUROSPORINE, ... Authors: Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F. Deposit date: 2003-08-01 Release date: 2004-07-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition Biochem.J., 375, 2003
1OKZ	Structure of human PDK1 kinase domain in complex with UCN-01 Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, 7-HYDROXYSTAUROSPORINE, GLYCEROL, ... Authors: Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F. Deposit date: 2003-08-01 Release date: 2004-07-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition Biochem.J., 375, 2003
1OL1	Cyclin A binding groove inhibitor H-Cit-Cit-Leu-Ile-(p-F-Phe)-NH2 Descriptor: CELL DIVISION PROTEIN KINASE 2, CIR-CIR-LEU-ILE-PFF-NH2, CYCLIN A2 Authors: Kontopidis, G, Andrews, M, McInnes, C, Cowan, A, Powers, H, Innes, L, Plater, A, Griffiths, G, Paterson, D, Zheleva, D, Lane, D, Green, S, Walkinshaw, M, Fischer, P. Deposit date: 2003-08-04 Release date: 2003-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange Structure, 11, 2003
1OL2	Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Asn-(p-F-Phe)-NH2 Descriptor: ARG-ARG-LEU-ASN-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 Authors: Kontopidis, G, Andrews, M, McInnes, C, Cowan, A, Powers, H, Innes, L, Plater, A, Griffiths, G, Paterson, D, Zheleva, D, Lane, D, Green, S, Walkinshaw, M, Fischer, P. Deposit date: 2003-08-05 Release date: 2003-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange Structure, 11, 2003
1OL5	Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43 Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ... Authors: Bayliss, R, Conti, E. Deposit date: 2003-08-06 Release date: 2003-10-30 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle Mol.Cell, 12, 2003

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