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7SL3	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL4	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL2	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL6	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7S8V	Leg region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-09-20 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.73 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7S0Q	Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-08-30 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7STH	Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STI	Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound) asymmetric conformation Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-13 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STJ	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 1) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7STK	Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric conformation (Conformation 2) Descriptor: Insulin, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-11-14 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
8TAN	CryoEM structure of MFRV-VILP bound to IGF1Rzip Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ... Authors: Kirk, N.S. Deposit date: 2023-06-27 Release date: 2024-01-17 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression. Mol Metab, 80, 2024
8U4C	Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. Descriptor: Insulin receptor, Insulin-like growth factor II Authors: An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. Deposit date: 2023-09-10 Release date: 2024-03-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
8U4B	Cryo-EM structure of long form insulin receptor (IR-B) in the apo state Descriptor: Insulin receptor Authors: An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. Deposit date: 2023-09-10 Release date: 2024-03-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
8U4E	Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. Descriptor: Insulin receptor, Insulin-like growth factor II Authors: An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. Deposit date: 2023-09-10 Release date: 2024-03-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
7U7N	IL-27 quaternary receptor signaling complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... Authors: Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. Deposit date: 2022-03-07 Release date: 2022-05-25 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structure of the IL-27 quaternary receptor signaling complex. Elife, 11, 2022
7U6E	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ... Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (3 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U6D	Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459 Descriptor: IM459, Isoform Short of Insulin receptor Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-03-03 Release date: 2022-10-05 Method: ELECTRON MICROSCOPY (5.03 Å) Cite: Activation of the human insulin receptor by non-insulin-related peptides Nat Commun, 13, 2022
7U23	Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide Authors: Kirk, N.S, Lawrence, M.C. Deposit date: 2022-02-22 Release date: 2022-11-16 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun, 13, 2022
8DTM	Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 Descriptor: Insulin mimetic peptide S597 component 2, Insulin receptor Authors: Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. Deposit date: 2022-07-26 Release date: 2022-09-07 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
8DTL	Cryo-EM structure of insulin receptor (IR) bound with S597 peptide Descriptor: Insulin mimetic peptide S597, Insulin receptor Authors: Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. Deposit date: 2022-07-25 Release date: 2022-09-07 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (5.4 Å) Cite: Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
8D74	Cryo-EM structure of human CNTF signaling complex: model containing the interaction core region Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ciliary neurotrophic factor, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-07 Release date: 2023-03-29 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
8D82	Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-07 Release date: 2023-03-29 Method: ELECTRON MICROSCOPY (3.22 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
8D6A	Cryo-EM structure of human LIF signaling complex: model containing the interaction core region Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6 receptor subunit beta, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-06 Release date: 2023-03-29 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
8D85	Cryo-EM structure of human IL-27 signaling complex: model containing the interaction core region Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-07 Release date: 2023-03-29 Method: ELECTRON MICROSCOPY (3.81 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023
8D7H	Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cardiotrophin-like cytokine factor 1, ... Authors: Zhou, Y, Franklin, M.C. Deposit date: 2022-06-07 Release date: 2023-03-29 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9, 2023

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