8D6A

Cryo-EM structure of human LIF signaling complex: model containing the interaction core region

Summary for 8D6A

Entry DOI	10.2210/pdb8d6a/pdb
EMDB information	27221
Descriptor	Leukemia inhibitory factor, Interleukin-6 receptor subunit beta, Leukemia inhibitory factor receptor, ... (5 entities in total)
Functional Keywords	cytokine signaling, lif, gp130, lifr, cytokine
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	186948.84
Authors	Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-06, release date: 2023-03-29)
Primary citation	Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C. Structural insights into the assembly of gp130 family cytokine signaling complexes. Sci Adv, 9:eade4395-eade4395, 2023 Cited by PubMed: 36930708 DOI: 10.1126/sciadv.ade4395 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.54 Å)

Structure validation