8U4E

Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation.

Summary for 8U4E

• Entry DOI: 10.2210/pdb8u4e/pdb
• EMDB information: 41880
• Descriptor: Insulin receptor, Insulin-like growth factor II (2 entities in total)
• Functional Keywords: insulin receptor, igf2, rtk, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 373547.85

Authors

An, W.,Hall, C.,Li, J.,Huang, A.,Wu, J.,Park, J.,Bai, X.C.,Choi, E. (deposition date: 2023-09-10, release date: 2024-03-27, Last modification date: 2024-04-03)

• Primary citation: An, W.,Hall, C.,Li, J.,Hung, A.,Wu, J.,Park, J.,Wang, L.,Bai, X.C.,Choi, E.; Activation of the insulin receptor by insulin-like growth factor 2.; Nat Commun, 15:2609-2609, 2024; PubMed: 38521788; DOI: 10.1038/s41467-024-46990-6

Experimental method

ELECTRON MICROSCOPY (4.2 Å)