PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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7RNS	nSH2 domain of p85-alpha subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.14 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNV	SH2 domain of guanine nucleotide exchange factor Vav2 in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7RNU	nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53 Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ... Authors: Dai, S, Horton, J.R, Cheng, X. Deposit date: 2021-07-29 Release date: 2021-08-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.45 Å) Cite: The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin To Be Published
7R8X	Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7R8W	Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3 Authors: Morris, R, Kershaw, N.J, Babon, J.J. Deposit date: 2021-06-27 Release date: 2021-10-06 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK. Nat Commun, 12, 2021
7SA7	Crystal structure of the apo SH2 domains of Syk Descriptor: Tyrosine-protein kinase SYK Authors: Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. Deposit date: 2021-09-22 Release date: 2021-10-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION Authors: Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) Descriptor: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src Authors: Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. Deposit date: 2003-04-11 Release date: 2003-08-19 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.63 Å) Cite: The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1PIC	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE Descriptor: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE Authors: Breeze, A.L, Kara, B.V, Barratt, D.G, Anderson, M, Smith, J.C, Luke, R.W, Best, J.R, Cartlidge, S.A. Deposit date: 1997-06-23 Release date: 1997-09-17 Last modified: 2022-02-23 Method: SOLUTION NMR Cite: Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. EMBO J., 15, 1996
1QAD	Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate Descriptor: PI3-KINASE P85 ALPHA SUBUNIT Authors: Hoedemaeker, P.J, Siegal, G, Roe, M, Driscoll, P.C, Abrahams, J.P.A. Deposit date: 1999-02-26 Release date: 1999-10-27 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate. J.Mol.Biol., 292, 1999
1QG1	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE Descriptor: PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN), PROTEIN (SHC-DERIVED PEPTIDE) Authors: Ogura, K. Deposit date: 1999-04-19 Release date: 1999-04-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. J.Mol.Biol., 289, 1999
1R1Q	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2018-04-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1RJA	Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain Descriptor: Tyrosine-protein kinase 6 Authors: Hong, E, Shin, J, Lee, W. Deposit date: 2003-11-18 Release date: 2004-07-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain J.Biol.Chem., 279, 2004
1R1P	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads Descriptor: GRB2-related adaptor protein 2, LAT pY171 peptide, SULFATE ION Authors: Cho, S, Mariuzza, R.A. Deposit date: 2003-09-24 Release date: 2004-09-28 Last modified: 2020-01-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS Descriptor: SULFATE ION, adaptor protein APS Authors: Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. Deposit date: 2003-12-03 Release date: 2003-12-23 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1SHB	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE B, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHA	CRYSTAL STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN SH2 OF V-SRC COMPLEXED WITH TYROSINE-PHOSPHORYLATED PEPTIDES Descriptor: PHOSPHOPEPTIDE A, V-SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1992-08-18 Release date: 1993-10-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. Nature, 358, 1992
1SHD	PEPTIDE INHIBITORS OF SRC SH3-SH2-PHOSPHOPROTEIN INTERACTIONS Descriptor: C-SRC TYROSINE KINASE SH2 DOMAIN, TRKA RECEPTOR Authors: Gilmer, T, Jordan, S. Deposit date: 1994-11-10 Release date: 1995-01-26 Last modified: 2012-02-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. J.Biol.Chem., 269, 1994
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PEPTIDE YEEI, SRC SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX Descriptor: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN Authors: Holland, D.R, Rubin, J.R. Deposit date: 1997-09-18 Release date: 1998-02-25 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2 Å) Cite: Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS Descriptor: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN Authors: Waksman, G, Kuriyan, J. Deposit date: 1993-03-05 Release date: 1994-05-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1TZE	SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 Authors: Rahuel, J, Grutter, M.G. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2011-11-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996

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