PDB: 593 resultsInfo pagesStatus searchChemie searchBIRD

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5UKJ	The co-structure of N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed PI3K-alpha mutant that mimics ATR Descriptor: N,N-dimethyl-4-[(6R)-6-methyl-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl]benzenesulfonamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Knapp, M.S, Elling, R.A, Mamo, M. Deposit date: 2017-01-23 Release date: 2017-05-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
5UK8	The co-structure of (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed PI3K-alpha mutant that mimics ATR Descriptor: (R)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1H-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Knapp, M.S, Mamo, M, Elling, R.A. Deposit date: 2017-01-20 Release date: 2017-06-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Rationally Designed PI3K alpha Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors. J. Mol. Biol., 429, 2017
1AD5	SRC FAMILY KINASE HCK-AMP-PNP COMPLEX Descriptor: CALCIUM ION, HAEMATOPOETIC CELL KINASE HCK, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Sicheri, F, Moarefi, I, Kuriyan, J. Deposit date: 1997-02-20 Release date: 1997-05-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 1997
1A81	CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM Descriptor: SYK KINASE, T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN Authors: Fuetterer, K, Waksman, G. Deposit date: 1998-03-31 Release date: 1998-10-21 Last modified: 2016-05-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J.Mol.Biol., 281, 1998
1BG1	TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR STAT3B) Authors: Becker, S, Groner, B, Muller, C.W. Deposit date: 1998-06-03 Release date: 1999-01-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature, 394, 1998
1BF5	TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX Descriptor: DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3'), SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA Authors: Kuriyan, J, Zhao, Y, Chen, X, Vinkemeier, U, Jeruzalmi, D, Darnell Jr, J.E. Deposit date: 1998-05-27 Release date: 1998-08-12 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell(Cambridge,Mass.), 93, 1998
2C9W	CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION Descriptor: NICKEL (II) ION, SULFATE ION, SUPPRESSOR OF CYTOKINE SIGNALING 2, ... Authors: Debreczeni, J.E, Bullock, A, Amos, A, Savitsky, P, Barr, A, Burgess, N, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S. Deposit date: 2005-12-14 Release date: 2006-02-22 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
2DVJ	phosphorylated Crk-II Descriptor: V-crk sarcoma virus CT10 oncogene homolog, isoform a Authors: Kobashigawa, Y, Inagaki, F. Deposit date: 2006-07-31 Release date: 2007-05-08 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
2EYZ	CT10-Regulated Kinase isoform II Descriptor: v-crk sarcoma virus CT10 oncogene homolog isoform a Authors: Kobashigawa, Y, Tanaka, S, Inagaki, F. Deposit date: 2005-11-10 Release date: 2006-11-10 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
2EYY	CT10-Regulated Kinase isoform I Descriptor: v-crk sarcoma virus CT10 oncogene homolog isoform a Authors: Kobashigawa, Y, Tanaka, S, Inagaki, F. Deposit date: 2005-11-10 Release date: 2006-11-10 Last modified: 2022-03-09 Method: SOLUTION NMR Cite: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat.Struct.Mol.Biol., 14, 2007
2FO0	Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... Authors: Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J. Deposit date: 2006-01-12 Release date: 2006-03-21 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol.Cell, 21, 2006
2H8H	Src kinase in complex with a quinazoline inhibitor Descriptor: N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE, Proto-oncogene tyrosine-protein kinase Src Authors: Otterbein, L.R, Norman, R, Pauptit, R.A, Rowsell, S, Breed, J. Deposit date: 2006-06-07 Release date: 2006-11-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J.Med.Chem., 49, 2006
2HCK	SRC FAMILY KINASE HCK-QUERCETIN COMPLEX Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, CALCIUM ION, HEMATOPOETIC CELL KINASE HCK Authors: Sicheri, F, Moarefi, I, Kuriyan, J. Deposit date: 1997-02-25 Release date: 1997-08-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 1997
1KSW	Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP Descriptor: N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Authors: Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. Deposit date: 2002-01-14 Release date: 2002-02-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
1LCK	SH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA Descriptor: P56==LCK== TYROSINE KINASE, TAIL PHOSPHOPEPTIDE TEGQ(PHOSPHO)YQPQPA Authors: Eck, M, Harrison, S. Deposit date: 1994-12-12 Release date: 1995-10-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature, 368, 1994
1M27	Crystal structure of SAP/FynSH3/SLAM ternary complex Descriptor: CITRATE ANION, Proto-oncogene tyrosine-protein kinase FYN, SH2 domain protein 1A, ... Authors: Chan, B, Griesbach, J, Song, H.K, Poy, F, Terhorst, C, Eck, M.J. Deposit date: 2002-06-21 Release date: 2003-05-06 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: SAP couples Fyn to SLAM immune receptors. NAT.CELL BIOL., 5, 2003
1OPK	Structural basis for the auto-inhibition of c-Abl tyrosine kinase Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... Authors: Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. Deposit date: 2003-03-06 Release date: 2003-04-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1OPL	Structural basis for the auto-inhibition of c-Abl tyrosine kinase Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase Authors: Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. Deposit date: 2003-03-06 Release date: 2003-04-08 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (3.42 Å) Cite: Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003

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