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2FO0

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

Summary for 2FO0
Entry DOI10.2210/pdb2fo0/pdb
DescriptorProto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM), MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ... (5 entities in total)
Functional Keywordsn-terminal cap, autoinhibition, myristoylation, sh3-sh2 clamp, phosphoserine, transferase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains1
Total formula weight57292.21
Authors
Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2006-01-12, release date: 2006-03-21, Last modification date: 2023-08-30)
Primary citationNagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J.
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21:787-798, 2006
Cited by
PubMed: 16543148
DOI: 10.1016/j.molcel.2006.01.035
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.27 Å)
Structure validation

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