1A81
CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM
Summary for 1A81
Entry DOI | 10.2210/pdb1a81/pdb |
Descriptor | SYK KINASE, T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN (2 entities in total) |
Functional Keywords | complex (transferase-peptide), syk, kinase, sh2 domain, itam, complex (transferase-peptide) complex, complex (transferase/peptide) |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane : P43405 Cell membrane ; Single-pass type I membrane protein : P07766 |
Total number of polymer chains | 12 |
Total formula weight | 186697.03 |
Authors | Fuetterer, K.,Waksman, G. (deposition date: 1998-03-31, release date: 1998-10-21, Last modification date: 2016-05-25) |
Primary citation | Futterer, K.,Wong, J.,Grucza, R.A.,Chan, A.C.,Waksman, G. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. J.Mol.Biol., 281:523-537, 1998 Cited by PubMed: 9698567DOI: 10.1006/jmbi.1998.1964 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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