PDB: 114 resultsInfo pagesStatus searchChemie searchBIRD

---

7A08	CryoEM Structure of cGAS Nucleosome complex Descriptor: Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... Authors: Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. Deposit date: 2020-08-07 Release date: 2020-09-23 Last modified: 2021-02-10 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature, 587, 2020
6PZV	Crystal Structure of Bovine DNMT1 RFTS domain in complex with H3K9me3 and Ubiquitin Descriptor: CITRATE ANION, DNA (cytosine-5)-methyltransferase 1, Histone H3.3, ... Authors: Ren, W, Song, J. Deposit date: 2019-08-01 Release date: 2020-07-15 Last modified: 2020-08-12 Method: X-RAY DIFFRACTION (3.01 Å) Cite: Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proc.Natl.Acad.Sci.USA, 117, 2020
3ASK	Structure of UHRF1 in complex with histone tail Descriptor: E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ZINC ION Authors: Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. Deposit date: 2010-12-16 Release date: 2012-01-25 Last modified: 2013-06-05 Method: X-RAY DIFFRACTION (2.904 Å) Cite: Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
4W5A	Complex structure of ATRX ADD bound to H3K9me3S10ph peptide Descriptor: Peptide from Histone H3.3, Transcriptional regulator ATRX, ZINC ION Authors: Zhao, D, Xiang, B, Li, H. Deposit date: 2014-08-17 Release date: 2015-01-21 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons Proc.Natl.Acad.Sci.USA, 112, 2015
7OKP	Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol, Histone H3.3, Histone-arginine methyltransferase CARM1, ... Authors: Marechal, N, Cura, V, Troffer-Charlier, N, Bonnefond, L, Cavarelli, J. Deposit date: 2021-05-18 Release date: 2021-10-27 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors. Chembiochem, 22, 2021
1PDQ	Polycomb chromodomain complexed with the histone H3 tail containing trimethyllysine 27. Descriptor: Histone H3.3, Polycomb protein Authors: Fischle, W, Wang, Y, Jacobs, S.A, Kim, Y, Allis, C.D, Khorasanizadeh, S. Deposit date: 2003-05-20 Release date: 2003-08-26 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains Genes Dev., 17, 2003
3JVK	Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, histone H3.3 peptide Authors: Vollmuth, F, Blankenfeldt, W, Geyer, M. Deposit date: 2009-09-17 Release date: 2009-10-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
6HGT	Crystal structure of human KDM4A complexed with co-substrate analog NOG and histone H3 peptide with K9R mutation Descriptor: Histone H3.3, Lysine-specific demethylase 4A, N-OXALYLGLYCINE, ... Authors: Maw, J, Le Bihan, Y.V, van Montfort, R.L.M. Deposit date: 2018-08-23 Release date: 2019-09-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structure-based design of selective, histone substrate-based inhibitors of histone lysine demethylases 4 (KDM4) subfamily To be published
7CWH	Structural basis of RACK7 PHD to read a pediatric glioblastoma-associated histone mutation H3.3G34R Descriptor: Peptide from Histone H3.3, Protein kinase C-binding protein 1, ZINC ION Authors: Lan, W.X, Li, Z, Jiao, F.F, Wang, C.X, Guo, R, Cao, C.Y. Deposit date: 2020-08-28 Release date: 2021-05-26 Method: SOLUTION NMR Cite: Structural basis of RACK7 PHD domain to read a pediatric glioblastoma‐associated histone mutation H3.3G34R Chin.J.Chem., 2021
4O62	CW-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 Descriptor: Histone H3.3, UNKNOWN ATOM OR ION, ZINC ION, ... Authors: Liu, Y, Tempel, W, Dong, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2013-12-20 Release date: 2014-03-26 Last modified: 2016-06-08 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. J.Biol.Chem., 291, 2016
2RHU	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine and in chimera with histone H3.3(28-34) Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, N-DIMETHYL-LYSINE, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
4U7T	Crystal structure of DNMT3A-DNMT3L in complex with histone H3 Descriptor: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y. Deposit date: 2014-07-31 Release date: 2014-11-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
6R0C	Human-D02 Nucleosome Core Particle with biotin-streptavidin label Descriptor: DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... Authors: Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A. Deposit date: 2019-03-12 Release date: 2019-09-25 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
6RNY	PFV intasome - nucleosome strand transfer complex Descriptor: DNA (108-MER), DNA (128-MER), DNA (33-MER), ... Authors: Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. Deposit date: 2019-05-09 Release date: 2019-09-25 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
6U04	Crystal structure of human BRPF1 PZP bound to histone H3 tail Descriptor: Histone H3.3,BRPF1, Peregrin, PRASEODYMIUM ION, ... Authors: Klein, B.J, Kutateladze, T.G. Deposit date: 2019-08-13 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin. Structure, 28, 2020
3ASL	Structure of UHRF1 in complex with histone tail Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ... Authors: Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. Deposit date: 2010-12-16 Release date: 2012-01-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
7VCQ	structure of viral protein BKRF4 in complex with H3.3-H4-ASF1 Descriptor: Histone H3.3, Histone H4, Histone chaperone ASF1B, ... Authors: Liu, Y.R. Deposit date: 2021-09-03 Release date: 2022-08-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Epstein-Barr Virus Tegument Protein BKRF4 is a Histone Chaperone. J.Mol.Biol., 434, 2022
7V1M	Structural basis for the co-chaperone relationship of sNASP and ASF1b Descriptor: Histone H3.3, Histone H4, Histone chaperone ASF1B, ... Authors: Bao, H, Huang, H. Deposit date: 2021-08-04 Release date: 2022-04-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.834 Å) Cite: NASP maintains histone H3-H4 homeostasis through two distinct H3 binding modes. Nucleic Acids Res., 50, 2022
5JA4	Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA replication licensing factor MCM2, GLYCEROL, ... Authors: Huang, H, Patel, D. Deposit date: 2016-04-11 Release date: 2016-06-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.424 Å) Cite: H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature, 534, 2016
8JH3	RNA polymerase II elongation complex containing 40 bp upstream DNA loop, stalled at SHL(-1) of the nucleosome Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. Deposit date: 2023-05-22 Release date: 2023-11-29 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
8JH4	RNA polymerase II elongation complex containing 60 bp upstream DNA loop, stalled at SHL(-1) of the nucleosome Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... Authors: Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. Deposit date: 2023-05-22 Release date: 2023-11-29 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
8JH2	RNA polymerase II elongation complex bound with Elf1, Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome Descriptor: DNA (218-MER), DNA (40-MER), DNA-directed RNA polymerase subunit, ... Authors: Akatsu, M, Fujita, R, Ogasawara, M, Ehara, H, Kujirai, T, Takizawa, Y, Sekine, S, Kurumizaka, H. Deposit date: 2023-05-22 Release date: 2023-11-29 Last modified: 2023-12-20 Method: ELECTRON MICROSCOPY (5.7 Å) Cite: Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA. J.Biol.Chem., 299, 2023
3MUL	Crystal structure of Brd4 bromodomain 1 with butyrylated histone H3-K(buty)14 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Peptide of Histone H3.3 Authors: Vollmuth, F, Geyer, M. Deposit date: 2010-05-03 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains Angew.Chem.Int.Ed.Engl., 49, 2010
3MUK	Crystal structure of Brd4 bromodomain 1 with propionylated histone H3-K(prop)23 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, peptide of Histone H3.3 Authors: Vollmuth, F, Geyer, M. Deposit date: 2010-05-03 Release date: 2010-08-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains Angew.Chem.Int.Ed.Engl., 49, 2010
7CJ0	Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD Descriptor: DNA replication licensing factor MCM2, DnaJ homolog subfamily C member 9, GLYCEROL, ... Authors: Bao, H, Huang, H. Deposit date: 2020-07-09 Release date: 2021-04-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. Mol.Cell, 81, 2021

<12345>