PDB: 334 resultsInfo pagesStatus searchChemie searchBIRD

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6OF7	Crystal structure of the CRY1-PER2 complex Descriptor: Cryptochrome-1, Period circadian protein homolog 2 Authors: Michael, A.K, Fribourgh, J.L, Tripathi, S.M, Partch, C.L. Deposit date: 2019-03-28 Release date: 2020-03-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.11 Å) Cite: Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Elife, 9, 2020
8OSK	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSL	Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (4.9 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
8OSJ	Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... Authors: Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. Deposit date: 2023-04-19 Release date: 2023-05-24 Last modified: 2023-07-26 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Cooperation between bHLH transcription factors and histones for DNA access. Nature, 619, 2023
3FY4	(6-4) Photolyase Crystal Structure Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-4 photolyase, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Hitomi, K, Arvai, A.S, Tainer, J.A, Getzoff, E.D. Deposit date: 2009-01-21 Release date: 2009-04-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc.Natl.Acad.Sci.USA, 106, 2009
5JYU	NMR structure of pseudo receiver domain of CikA from Thermosynechococcus elongatus Descriptor: Two-component sensor histidine kinase Authors: Tseng, R.D, LiWang, A.L. Deposit date: 2016-05-15 Release date: 2017-03-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural basis of the day-night transition in a bacterial circadian clock. Science, 355, 2017
2KDK	Structure of human circadian clock protein BMAL2 C-terminal PAS domain Descriptor: Aryl hydrocarbon receptor nuclear translocator-like protein 2 Authors: Wasielewski, E, Correia, C, Prendergast, F.G, Mer, G. Deposit date: 2009-01-10 Release date: 2011-04-13 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of human circadian clock protein BMAL2 C-terminal PAS domain To be Published
3GEC	Crystal structure of a tandem PAS domain fragment of Drosophila PERIOD Descriptor: Period circadian protein Authors: Yildiz, O, Wolf, E. Deposit date: 2009-02-25 Release date: 2009-06-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (4 Å) Cite: Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2 Plos Biol., 7, 2009
2E47	Crystal Structure Analysis of the clock protein EA4 (glycosylation form) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Time interval measuring enzyme TIME, ... Authors: Park, S.-Y, Hiraki, T. Deposit date: 2006-12-05 Release date: 2007-12-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.11 Å) Cite: the clock protein EA4 ticks away with movement of a mobile copper ion To be Published
2E46	Crystal Structure Analysis of the clock protein EA4 Descriptor: COPPER (II) ION, Time interval measuring enzyme TIME, ZINC ION Authors: Park, S.-Y, Hiraki, T. Deposit date: 2006-12-05 Release date: 2008-02-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: the clock protein EA4 ticks away with movement of a mobile copper ion To be Published
7V8Y	Crystal structure of mouse CRY2 in complex with SHP1703 compound Descriptor: 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one, Cryptochrome-2 Authors: Miller, S.A, Hirota, T. Deposit date: 2021-08-23 Release date: 2022-08-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA, 119, 2022
7V8Z	Crystal structure of mouse CRY2 in complex with SHP656 compound Descriptor: 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one, Cryptochrome-2 Authors: Miller, S.A, Hirota, T. Deposit date: 2021-08-23 Release date: 2022-08-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA, 119, 2022
7D1C	Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 Descriptor: Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide Authors: Miller, S.A, Hirota, T. Deposit date: 2020-09-14 Release date: 2021-01-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7D19	Crystal structure of mouse Cryptochrome 1 in complex with compound TH129 Descriptor: Cryptochrome-1, N-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide Authors: Miller, S.A, Hirota, T. Deposit date: 2020-09-14 Release date: 2021-01-27 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
7DYE	Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION Authors: Furuike, Y, Akiyama, S. Deposit date: 2021-01-21 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Regulation mechanisms of the dual ATPase in KaiC. Proc.Natl.Acad.Sci.USA, 119, 2022
8DD7	The Cryo-EM structure of Drosophila Cryptochrome in complex with Timeless Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Methylated-DNA--protein-cysteine methyltransferase,Cryptochrome-1 fusion, Protein timeless,Methylated-DNA--protein-cysteine methyltransferase fusion Authors: Feng, S, Lin, C, DeOliveira, C.C, Crane, B.R. Deposit date: 2022-06-17 Release date: 2023-02-15 Last modified: 2023-05-17 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryptochrome-Timeless structure reveals circadian clock timing mechanisms. Nature, 617, 2023
5X17	Crystal structure of murine CK1d in complex with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, SULFATE ION Authors: Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. Deposit date: 2017-01-25 Release date: 2017-10-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
5X18	Crystal structure of Casein kinase I homolog 1 Descriptor: Casein kinase I homolog 1, GLYCEROL, MALONIC ACID Authors: Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T. Deposit date: 2017-01-25 Release date: 2017-10-04 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Mol. Cell, 67, 2017
3SD0	Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice Descriptor: 3-(5-fluoro-6-iodo-1-methyl-1H-indol-3-yl)-4-(7-methoxy-1-benzofuran-3-yl)-1H-pyrrole-2,5-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Glycogen synthase kinase-3 beta Authors: Mesecar, A.M, Walters, R.L. Deposit date: 2011-06-08 Release date: 2011-08-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice To be Published
7DY1	Crystal Structure of Cyanobacterial Circadian Clock Protein KaiC Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION Authors: Furuike, Y, Akiyama, S. Deposit date: 2021-01-20 Release date: 2022-05-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Regulation mechanisms of the dual ATPase in KaiC. Proc.Natl.Acad.Sci.USA, 119, 2022
1T4Z	Solution structure of the N-terminal domain of Synechococcus elongatus SasA (25-structures ensemble) Descriptor: Adaptive-response sensory-kinase sasA Authors: Vakonakis, I, Klewer, D.A, LiWang, A.C. Deposit date: 2004-04-30 Release date: 2004-11-16 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA. J.Mol.Biol., 342, 2004
1T4Y	Solution structure of the N-terminal domain of Synechococcus elongatus SasA (average minimized structure) Descriptor: Adaptive-response sensory-kinase sasA Authors: Vakonakis, I, Klewer, D.A, LiWang, A.C. Deposit date: 2004-04-30 Release date: 2004-11-16 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure of the N-terminal domain of the circadian clock-associated histidine kinase SasA. J.Mol.Biol., 342, 2004
6DHP	RT XFEL structure of the three-flash state of Photosystem II (3F, S0-rich) at 2.04 Angstrom resolution Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... Authors: Kern, J, Chatterjee, R, Young, I.D, Fuller, F.D, Lassalle, L, Ibrahim, M, Gul, S, Fransson, T, Brewster, A.S, Alonso-Mori, R, Hussein, R, Zhang, M, Douthit, L, de Lichtenberg, C, Cheah, M.H, Shevela, D, Wersig, J, Seufert, I, Sokaras, D, Pastor, E, Weninger, C, Kroll, T, Sierra, R.G, Aller, P, Butryn, A, Orville, A.M, Liang, M, Batyuk, A, Koglin, J.E, Carbajo, S, Boutet, S, Moriarty, N.W, Holton, J.M, Dobbek, H, Adams, P.D, Bergmann, U, Sauter, N.K, Zouni, A, Messinger, J, Yano, J, Yachandra, V.K. Deposit date: 2018-05-20 Release date: 2018-11-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Structures of the intermediates of Kok's photosynthetic water oxidation clock. Nature, 563, 2018
6DHH	RT XFEL structure of Photosystem II 400 microseconds after the second illumination at 2.2 Angstrom resolution Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... Authors: Kern, J, Chatterjee, R, Young, I.D, Fuller, F.D, Lassalle, L, Ibrahim, M, Gul, S, Fransson, T, Brewster, A.S, Alonso-Mori, R, Hussein, R, Zhang, M, Douthit, L, de Lichtenberg, C, Cheah, M.H, Shevela, D, Wersig, J, Seufert, I, Sokaras, D, Pastor, E, Weninger, C, Kroll, T, Sierra, R.G, Aller, P, Butryn, A, Orville, A.M, Liang, M, Batyuk, A, Koglin, J.E, Carbajo, S, Boutet, S, Moriarty, N.W, Holton, J.M, Dobbek, H, Adams, P.D, Bergmann, U, Sauter, N.K, Zouni, A, Messinger, J, Yano, J, Yachandra, V.K. Deposit date: 2018-05-20 Release date: 2018-11-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of the intermediates of Kok's photosynthetic water oxidation clock. Nature, 563, 2018
6DHF	RT XFEL structure of the one-flash state of Photosystem II (1F, S2-rich) at 2.08 Angstrom resolution Descriptor: 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... Authors: Kern, J, Chatterjee, R, Young, I.D, Fuller, F.D, Lassalle, L, Ibrahim, M, Gul, S, Fransson, T, Brewster, A.S, Alonso-Mori, R, Hussein, R, Zhang, M, Douthit, L, de Lichtenberg, C, Cheah, M.H, Shevela, D, Wersig, J, Seufert, I, Sokaras, D, Pastor, E, Weninger, C, Kroll, T, Sierra, R.G, Aller, P, Butryn, A, Orville, A.M, Liang, M, Batyuk, A, Koglin, J.E, Carbajo, S, Boutet, S, Moriarty, N.W, Holton, J.M, Dobbek, H, Adams, P.D, Bergmann, U, Sauter, N.K, Zouni, A, Messinger, J, Yano, J, Yachandra, V.K. Deposit date: 2018-05-20 Release date: 2018-11-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structures of the intermediates of Kok's photosynthetic water oxidation clock. Nature, 563, 2018

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