7D1C

Crystal structure of mouse Cryptochrome 1 in complex with compound TH303

Summary for 7D1C

Entry DOI	10.2210/pdb7d1c/pdb
Descriptor	Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide (3 entities in total)
Functional Keywords	cryptochrome, cry, cry1, clock, circadian clock protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	57859.26
Authors	Miller, S.A.,Hirota, T. (deposition date: 2020-09-14, release date: 2021-01-27, Last modification date: 2023-11-29)
Primary citation	Kolarski, D.,Miller, S.,Oshima, T.,Nagai, Y.,Aoki, Y.,Kobauri, P.,Srivastava, A.,Sugiyama, A.,Amaike, K.,Sato, A.,Tama, F.,Szymanski, W.,Feringa, B.L.,Itami, K.,Hirota, T. Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143:2078-2087, 2021 Cited by PubMed: 33464888 DOI: 10.1021/jacs.0c12280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation