7V8Y

Crystal structure of mouse CRY2 in complex with SHP1703 compound

Summary for 7V8Y

Entry DOI	10.2210/pdb7v8y/pdb
Descriptor	Cryptochrome-2, 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one (3 entities in total)
Functional Keywords	circadian, clock, cryptochrome, cry, cry2, circadian clock protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	59192.54
Authors	Miller, S.A.,Hirota, T. (deposition date: 2021-08-23, release date: 2022-08-24, Last modification date: 2023-11-29)
Primary citation	Miller, S.,Kesherwani, M.,Chan, P.,Nagai, Y.,Yagi, M.,Cope, J.,Tama, F.,Kay, S.A.,Hirota, T. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proc.Natl.Acad.Sci.USA, 119:e2203936119-e2203936119, 2022 Cited by PubMed: 36161947 DOI: 10.1073/pnas.2203936119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation