PDB: 970 件ウェブページステータス検索Chemie searchBIRD

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4O22	Binary complex of metal-free PKAc with SP20. 分子名称: Phosphorylated peptide pSP20., cAMP-dependent protein kinase catalytic subunit alpha. 著者 Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S.S. 登録日 2013-12-16 公開日 2014-05-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
4O21	Product complex of metal-free PKAc, ATP-gamma-S and SP20. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Thio-phosphorylated peptide pSP20, cAMP-dependent protein kinase catalytic subunit alpha 著者 Das, A, Kovalevsky, A.Y, Gerlits, O, Langan, P, Heller, W.T, Keshwani, M, Taylor, S. 登録日 2013-12-16 公開日 2014-05-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer. Biochemistry, 53, 2014
3DT4	The structure of rat cytosolic PEPCK in complex with oxalate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2008-07-14 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DTB	The structure of rat cytosolic PEPCK in complex with phosphoglycolate and GDP 分子名称: 2-PHOSPHOGLYCOLIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2008-07-14 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT2	The structure of rat cytosolic PEPCK in complex with oxalate and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2008-07-14 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT7	The structure of rat cytosolic PEPCK in complex with beta-sulfopyruvate and GTP 分子名称: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Sullivan, S.M, Holyoak, T. 登録日 2008-07-14 公開日 2008-08-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection. Proc.Natl.Acad.Sci.Usa, 105, 2008
4OX2	I45T cytosolic phosphoenolpyruvate carboxykinase in complex with beta-sulfopyruvate and GTP 分子名称: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Holyoak, T. 登録日 2014-02-04 公開日 2014-06-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Mol.Genet.Metab., 113, 2014
3E9B	X-ray structure of rat arginase I-T135A mutant: the complex with BEC 分子名称: Arginase-1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE 著者 Shishova, E.Y, Di Costanzo, L, Christianson, D.W. 登録日 2008-08-21 公開日 2008-12-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Probing the specificity determinants of amino acid recognition by arginase. Biochemistry, 48, 2009
3E8Z	X-ray structure of rat arginase I-N130A mutant: the unliganded complex 分子名称: Arginase-1, MANGANESE (II) ION 著者 Shishova, E.Y, Di Costanzo, L, Christianson, D.W. 登録日 2008-08-20 公開日 2008-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Probing the specificity determinants of amino acid recognition by arginase. Biochemistry, 48, 2009
3ELN	A Putative Fe2+-bound Persulfenate Intermediate in Cysteine Dioxygenase 分子名称: Cysteine dioxygenase type 1, FE (II) ION, S-HYDROPEROXYCYSTEINE 著者 Simmons, C.R, Stipanuk, M.H, Karplus, P.A. 登録日 2008-09-22 公開日 2008-10-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry, 47, 2008
3E8Q	X-ray structure of rat arginase I-T135A: the unliganded complex 分子名称: Arginase-1, MANGANESE (II) ION 著者 Shishova, E.Y, Di Costanzo, L, Emig, F.A, Ash, D.E, Christianson, D.W. 登録日 2008-08-20 公開日 2008-12-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Probing the specificity determinants of amino acid recognition by arginase. Biochemistry, 48, 2009
3EIO	Crystal Structure Analysis of DPPIV Inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-({4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl}carbonyl)benzoic acid, ... 著者 Ahn, J.H, Lee, J.-O. 登録日 2008-09-17 公開日 2008-11-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 18, 2008
4PFC	Crystal structure of insulin degrading enzyme complexed with inhibitor 分子名称: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate 著者 Wang, Y, Guo, S. 登録日 2014-04-28 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
4PF9	Crystal structure of insulin degrading enzyme complexed with inhibitor 分子名称: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate 著者 Wang, Y, Guo, S. 登録日 2014-04-28 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
4PJY	Azide bound Cysteine Dioxygenase at pH 6.2 分子名称: AZIDE ION, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-05-12 公開日 2016-02-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.501 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
3F8S	Crystal structure of dipeptidyl peptidase IV in complex with inhibitor 分子名称: 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Ammirati, M.J, Liu, S, Piotrowski, D.W. 登録日 2008-11-13 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
3FHI	Crystal structure of a complex between the catalytic and regulatory (RI{alpha}) subunits of PKA 分子名称: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Kim, C. 登録日 2008-12-09 公開日 2009-04-14 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science, 307, 2005
4PNZ	Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102) 分子名称: (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Scapin, G, Yan, Y. 登録日 2014-02-22 公開日 2014-04-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes. J.Med.Chem., 57, 2014
4PV7	Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor 分子名称: 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine, Dipeptidyl peptidase 4 soluble form 著者 Xiao, P, Guo, R, Huang, S, Cui, H, Ye, S, Zhang, Z. 登録日 2014-03-15 公開日 2015-03-18 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett., 25, 2014
4PIY	Homocysteine bound Cysteine Dioxygenase C93A variant at pH 6.2 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-05-09 公開日 2016-02-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4PF7	Crystal structure of insulin degrading enzyme complexed with inhibitor 分子名称: (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION 著者 Wang, Y, Guo, S. 登録日 2014-04-28 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J.Biol.Chem., 290, 2015
4PIX	Unliganded Cysteine Dioxygenase C93A variant at pH 6.2 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-05-09 公開日 2016-02-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4PIZ	Homocysteine-bound Cysteine Dioxygenase at pH 6.2 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-05-09 公開日 2016-02-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
3FJQ	Crystal structure of cAMP-dependent protein kinase catalytic subunit alpha in complex with peptide inhibitor PKI alpha (6-25) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Kim, C. 登録日 2008-12-15 公開日 2009-08-04 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Comparative surface geometry of the protein kinase family. Protein Sci., 18, 2009
4Q9H	P-glycoprotein at 3.4 A resolution 分子名称: Multidrug resistance protein 1A 著者 McGrath, A.P, Szewczyk, P, Chang, G. 登録日 2014-05-01 公開日 2015-03-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein. Acta Crystallogr.,Sect.D, 71, 2015

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