1E7O
| A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V44I, V58L MUTATIONS | Descriptor: | GLYCEROL, SPECTRIN ALPHA CHAIN | Authors: | Vega, M.C, Serrano, L. | Deposit date: | 2000-08-31 | Release date: | 2003-05-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A Thermodynamic and Kinetic Analysis of the Folding Pathway of an SH3 Domain Entropically Stabilised by a Redesigned Hydrophobic Core J.Mol.Biol., 328, 2003
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1E6H
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1E6G
| A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT | Descriptor: | SPECTRIN ALPHA CHAIN, SULFATE ION | Authors: | Vega, M.C, Serrano, L. | Deposit date: | 2000-08-15 | Release date: | 2002-05-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
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1GCQ
| CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, VAV PROTO-ONCOGENE | Authors: | Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F. | Deposit date: | 2000-08-08 | Release date: | 2001-08-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Novel recognition mode between Vav and Grb2 SH3 domains. EMBO J., 20, 2001
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1GFD
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1FYN
| PHOSPHOTRANSFERASE | Descriptor: | 3BP-2, PHOSPHOTRANSFERASE FYN | Authors: | Musacchio, A, Saraste, M, Wilmanns, M. | Deposit date: | 1995-05-17 | Release date: | 1996-11-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides. Nat.Struct.Biol., 1, 1994
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1GFC
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1G2B
| ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48 | Descriptor: | SPECTRIN ALPHA CHAIN, SULFATE ION | Authors: | Berisio, R, Viguera, A.R, Serrano, L, Wilmanns, M. | Deposit date: | 2000-10-18 | Release date: | 2000-11-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Atomic resolution structure of a mutant of the spectrin SH3 domain. Acta Crystallogr.,Sect.D, 57, 2001
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1GCP
| CRYSTAL STRUCTURE OF VAV SH3 DOMAIN | Descriptor: | VAV PROTO-ONCOGENE | Authors: | Nishida, M, Nagata, K, Hachimori, Y, Ogura, K, Inagaki, F. | Deposit date: | 2000-08-08 | Release date: | 2001-08-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Novel recognition mode between Vav and Grb2 SH3 domains. EMBO J., 20, 2001
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1GL5
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1GBR
| ORIENTATION OF PEPTIDE FRAGMENTS FROM SOS PROTEINS BOUND TO THE N-TERMINAL SH3 DOMAIN OF GRB2 DETERMINED BY NMR SPECTROSCOPY | Descriptor: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, SOS-A PEPTIDE | Authors: | Wittekind, M, Mapelli, C, Farmer, B.T, Suen, K.-L, Goldfarb, V, Tsao, J, Lavoie, T, Barbacid, M, Meyers, C.A, Mueller, L. | Deposit date: | 1994-08-12 | Release date: | 1995-01-26 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy. Biochemistry, 33, 1994
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1GBQ
| SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, MINIMIZED AVERAGE STRUCTURE | Descriptor: | GRB2, SOS-1 | Authors: | Wittekind, M, Mapelli, C, Lee, V, Goldfarb, V, Friedrichs, M.S, Meyers, C.A, Mueller, L. | Deposit date: | 1996-12-23 | Release date: | 1997-09-04 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J.Mol.Biol., 267, 1997
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1H3H
| Structural Basis for Specific Recognition of an RxxK-containing SLP-76 peptide by the Gads C-terminal SH3 domain | Descriptor: | GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2 | Authors: | Liu, Q, Berry, D, Nash, P, Pawson, T, McGlade, C.J, Li, S.S. | Deposit date: | 2002-09-03 | Release date: | 2003-03-06 | Last modified: | 2013-07-24 | Method: | SOLUTION NMR | Cite: | Structural Basis for Specific Binding of the Gads SH3 Domain to an Rxxk Motif-Containing Slp-76 Peptide: A Novel Mode of Peptide Recognition Mol.Cell, 11, 2003
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1HD3
| A-SPECTRIN SH3 DOMAIN F52Y MUTANT | Descriptor: | GLYCEROL, SPECTRIN ALPHA CHAIN, SULFATE ION | Authors: | Vega, M.C, Viguera, A.R, Serrano, L. | Deposit date: | 2000-11-06 | Release date: | 2001-11-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Unspecific Hydrophobic Stabilization of Folding Transition States Proc.Natl.Acad.Sci.USA, 99, 2002
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4ESR
| Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors | Descriptor: | DI(HYDROXYETHYL)ETHER, Jouberin | Authors: | Van Petegem, X.F, Liu, P.X, Lobo, P, Jiang, X. | Deposit date: | 2012-04-23 | Release date: | 2012-06-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors. Proteomics, 12, 2012
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4F16
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4F17
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4FSS
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4GLM
| Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens] | Descriptor: | Dynamin-binding protein, UNKNOWN ATOM OR ION | Authors: | Dong, A, Guan, X, Huang, H, Tempel, W, Gu, J, Sidhu, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | Deposit date: | 2012-08-14 | Release date: | 2012-11-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens] to be published
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4GBQ
| SOLUTION NMR STRUCTURE OF THE GRB2 N-TERMINAL SH3 DOMAIN COMPLEXED WITH A TEN-RESIDUE PEPTIDE DERIVED FROM SOS DIRECT REFINEMENT AGAINST NOES, J-COUPLINGS, AND 1H AND 13C CHEMICAL SHIFTS, 15 STRUCTURES | Descriptor: | GRB2, SOS-1 | Authors: | Wittekind, M, Mapelli, C, Lee, V, Goldfarb, V, Friedrichs, M.S, Meyers, C.A, Mueller, L. | Deposit date: | 1996-12-23 | Release date: | 1997-09-04 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts. J.Mol.Biol., 267, 1997
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4HCK
| HUMAN HCK SH3 DOMAIN, NMR, 25 STRUCTURES | Descriptor: | HEMATOPOIETIC CELL KINASE | Authors: | Horita, D.A, Baldisseri, D.M, Zhang, W, Altieri, A.S, Smithgall, T.E, Gmeiner, W.H, Byrd, R.A. | Deposit date: | 1998-03-09 | Release date: | 1998-06-17 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Solution structure of the human Hck SH3 domain and identification of its ligand binding site. J.Mol.Biol., 278, 1998
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4HXJ
| Crystal structure of SH3:RGT complex | Descriptor: | C-terminal 3-mer peptide from Integrin beta-3, Proto-oncogene tyrosine-protein kinase Src | Authors: | Xiao, R, Meng, G. | Deposit date: | 2012-11-11 | Release date: | 2012-11-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural framework of c-Src activation by integrin beta 3 Blood, 121, 2013
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4HVV
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4HVU
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4HVW
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