4HVW

Crystal structure of the T98E c-Src-SH3 domain mutant in complex with the high affinity peptide VSL12

Summary for 4HVW

• Entry DOI: 10.2210/pdb4hvw/pdb
• Related: 1QWE 1QWF 1SRL 3FJ5 4HVU 4HVV
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, SYNTHETIC PEPTIDE Acetyl-VSLARRPLPPLP, ACETYL GROUP, ... (5 entities in total)
• Functional Keywords: beta shandwich, sh3 like barrel, kinase, proline rich motifs, signaling protein-peptide complex, signaling protein/peptide
• Biological source: Gallus gallus (bantam,chickens); More
• Cellular location: Cell membrane (By similarity): P00523
• Total number of polymer chains: 2
• Total formula weight: 8446.35

Authors

Camara-Artigas, A. (deposition date: 2012-11-07, release date: 2013-05-01, Last modification date: 2023-09-20)

• Primary citation: Bacarizo, J.,Camara-Artigas, A.; Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II.; Acta Crystallogr.,Sect.D, 69:756-766, 2013; PubMed: 23633584; DOI: 10.1107/S0907444913001522

Experimental method

X-RAY DIFFRACTION (0.98 Å)