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PDB: 4802 results Info pages Status search Chemie search BIRD

Crystal structure of non-phosphorylated Fus3
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3
Authors:	Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:	2005-10-11
Release date:	2006-01-03
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005

2B9J

Crystal structure of Fus3 with a docking motif from Far1
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, Cyclin-dependent kinase inhibitor FAR1, MAGNESIUM ION, ...
Authors:	Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:	2005-10-11
Release date:	2006-01-03
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005

2B9I

Crystal structure of Fus3 with a docking motif from Msg5
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:	Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:	2005-10-11
Release date:	2006-01-03
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005

2B9H

Crystal structure of Fus3 with a docking motif from Ste7
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:	Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:	2005-10-11
Release date:	2006-01-03
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol.Cell, 20, 2005

2BAL

p38alpha MAP kinase bound to pyrazoloamine
Descriptor:	Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
Authors:	Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J.
Deposit date:	2005-10-14
Release date:	2005-12-06
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005

2BAJ

p38alpha bound to pyrazolourea
Descriptor:	1-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea, Mitogen-activated protein kinase 14
Authors:	Gerhardt, S, Pauptit, R.A, Read, J, Breed, J, Norman, R.A, Ward, W.H.
Deposit date:	2005-10-14
Release date:	2005-12-06
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005

2BAQ

p38alpha bound to Ro3201195
Descriptor:	Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
Authors:	Gerhardt, S, Pauptit, R.A, Breed, J, Read, J, Tucker, J, Norman, R.A.
Deposit date:	2005-10-14
Release date:	2005-12-06
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005

2BAK

p38alpha MAP kinase bound to MPAQ
Descriptor:	Mitogen-activated protein kinase 14, N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE
Authors:	Gerhardt, S, Breed, J, Pauptit, R.A, Read, J, Norman, R.A, Ward, W.H.
Deposit date:	2005-10-14
Release date:	2005-12-06
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase Biochemistry, 44, 2005

2C47

Structure of casein kinase 1 gamma 2
Descriptor:	(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, CASEIN KINASE 1 GAMMA 2 ISOFORM, MAGNESIUM ION
Authors:	Bunkoczi, G, Rellos, P, Das, S, Ugochukwu, E, Fedorov, O, Sobott, F, Eswaran, J, Amos, A, Ball, L, von Delft, F, Bullock, A, Debreczeni, J, Turnbull, A, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S.
Deposit date:	2005-10-16
Release date:	2005-11-07
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	The Structure of Casein Kinase 1 Gamma 2 To be Published

2BCJ

Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
Descriptor:	G-protein-coupled receptor kinase 2, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:	Tesmer, J.J.G.
Deposit date:	2005-10-19
Release date:	2005-12-20
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (3.061 Å)
Cite:	Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex Science, 310, 2005

2C4G

STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514
Descriptor:	(3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ...
Authors:	Cameron, A, Fogliatto, G, Pevarello, P, Fancelli, D, Vulpetti, A, Amici, R, Villa, M, Pittala, V, Ciomei, M, Mercurio, C, Bischoff, J.R, Roletto, F, Varasi, M, Brasca, M.G.
Deposit date:	2005-10-19
Release date:	2005-11-23
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	3-Amino-1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: A New Class of Cdk2 Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006

2BDW

Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
Descriptor:	Hypothetical protein K11E8.1d
Authors:	Rosenberg, O.S, Kuriyan, J.
Deposit date:	2005-10-20
Release date:	2005-12-13
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure of the Autoinhibited Kinase Domain of CaMKII and SAXS Analysis of the Holoenzyme Cell(Cambridge,Mass.), 123, 2005

2ERZ

Crystal Structure of c-AMP Dependent Kinase (PKA) bound to hydroxyfasudil
Descriptor:	1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:	Jacobs, M.
Deposit date:	2005-10-25
Release date:	2005-11-08
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281, 2006

2ESM

Crystal Structure of ROCK 1 bound to fasudil
Descriptor:	5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, Rho-associated protein kinase 1
Authors:	Jacobs, M.
Deposit date:	2005-10-26
Release date:	2005-11-08
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281, 2006

2ETK

Crystal Structure of ROCK 1 bound to hydroxyfasudil
Descriptor:	1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, Rho-associated protein kinase 1
Authors:	Jacobs, M.
Deposit date:	2005-10-27
Release date:	2005-11-08
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.96 Å)
Cite:	The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281, 2006

2ETR

Crystal Structure of ROCK I bound to Y-27632
Descriptor:	(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE, Rho-associated protein kinase 1
Authors:	Jacobs, M.
Deposit date:	2005-10-27
Release date:	2005-11-08
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity. J.Biol.Chem., 281, 2006

2EU9

Crystal Structure of CLK3
Descriptor:	1,2-ETHANEDIOL, Dual specificity protein kinase CLK3
Authors:	Papagrigoriou, E, Rellos, P, Das, S, Ugochukwu, E, Turnbull, A, von Delft, F, Bunkoczi, G, Sobott, F, Bullock, A, Fedorov, O, Gileadi, C, Savitsky, P, Edwards, A, Aerrowsmith, C, Weigelt, J, Sundstrom, M, Knapp, S.
Deposit date:	2005-10-28
Release date:	2005-11-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.53 Å)
Cite:	Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure, 17, 2009

2EUF

X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
Descriptor:	6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ACETATE ION, CALCIUM ION, ...
Authors:	Schulze-Gahmen, U, Lu, H.
Deposit date:	2005-10-28
Release date:	2006-07-04
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006

2C5N

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Descriptor:	CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
Authors:	Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M.
Deposit date:	2005-10-30
Release date:	2006-03-01
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

2C5O

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Descriptor:	4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2
Authors:	Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M.
Deposit date:	2005-10-30
Release date:	2006-03-01
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

2EWA

Dual binding mode of pyridinylimidazole to MAP kinase p38
Descriptor:	4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, Mitogen-activated protein kinase 14
Authors:	Delarbre, L, Pouzieux, S, Guilloteau, J.-P, Michot, N.
Deposit date:	2005-11-02
Release date:	2006-08-01
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	NMR characterization of kinase p38 dynamics in free and ligand-bound forms. Angew.Chem.Int.Ed.Engl., 45, 2006

2C5V

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Descriptor:	4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ...
Authors:	Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M.
Deposit date:	2005-11-02
Release date:	2006-03-01
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

2C5Y

DIFFERENTIAL BINDING OF INHIBITORS TO ACTIVE AND INACTIVE CDK2 PROVIDES INSIGHTS FOR DRUG DESIGN
Descriptor:	CELL DIVISION PROTEIN KINASE 2, HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM
Authors:	Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M.
Deposit date:	2005-11-03
Release date:	2006-03-01
Last modified:	2019-01-30
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

2C5X

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design
Descriptor:	CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM
Authors:	Kontopidis, G, Mcinnes, C, Pandalaneni, S.R, Mcnae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M.
Deposit date:	2005-11-03
Release date:	2006-03-01
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006

2EXE

Crystal structure of the phosphorylated CLK3
Descriptor:	Dual specificity protein kinase CLK3
Authors:	Papagrigoriou, E, Rellos, P, Das, S, Bullock, A, Ball, L.J, Turnbull, A, Savitsky, P, Fedorov, O, Johansson, C, Ugochukwu, E, Sobott, F, von Delft, F, Edwards, A, Sundstrom, M, Weigelt, J, Arrowsmith, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2005-11-08
Release date:	2005-11-15
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Crystal structure of the phosphorylated CLK3 TO BE PUBLISHED

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Total results:	4802
Displayed results:	25
Sorted by:	Deposition date (from oldest)
Query:	PF00069