2ESM

Crystal Structure of ROCK 1 bound to fasudil

Summary for 2ESM

• Entry DOI: 10.2210/pdb2esm/pdb
• Related: 2ERZ 2ETK 2ETO 2ETR
• Descriptor: Rho-associated protein kinase 1, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (3 entities in total)
• Functional Keywords: kinase, dimer, dimerization, myosin, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13464
• Total number of polymer chains: 2
• Total formula weight: 96607.31

Authors

Jacobs, M. (deposition date: 2005-10-26, release date: 2005-11-08, Last modification date: 2023-08-23)

• Primary citation: Jacobs, M.,Hayakawa, K.,Swenson, L.,Bellon, S.,Fleming, M.,Taslimi, P.,Doran, J.; The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.; J.Biol.Chem., 281:260-268, 2006; PubMed: 16249185; DOI: 10.1074/jbc.M508847200

Experimental method

X-RAY DIFFRACTION (3.2 Å)